Zobrazeno 1 - 10
of 109
pro vyhledávání: '"Ming-Zong Lai"'
Autor:
Tzu-Sheng Hsu, Yen-Lin Lin, Yu-An Wang, Shu-Ting Mo, Po-Yu Chi, Alan Chuan-Ying Lai, Hsuan-Yin Pan, Ya-Jen Chang, Ming-Zong Lai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
HIF-1α is known to repress regulatory T (Treg) cell function, but less is known about the effect of HIF-2α on these cells. Here, the authors use three different mouse models of inflammatory diseases to show that HIF-2α limits HIF-1α expression an
Externí odkaz:
https://doaj.org/article/f95d5dd1646242e19c8c1bf174725c4d
Autor:
Chiung-Ya Chen, Yun-Fen Hung, Ching-Yen Tsai, Yi-Chun Shih, Ting-Fang Chou, Ming-Zong Lai, Ting-Fang Wang, Yi-Ping Hsueh
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Toll-like receptor (TLR) signaling is critical for defense against pathogenic infection, as well as for modulating tissue development. Activation of different TLRs triggers common inflammatory responses such as cytokine induction. Here, we reveal dif
Externí odkaz:
https://doaj.org/article/4a80fd0ab03a4b1b86a04c6c0bd7a29c
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-15 (2018)
XLP-2 syndrome is caused by XIAP mutation. Here the authors show that mouse and human XIAP-deficient regulatory T cells have defective suppressive function as a result of conversion to proinflammatory cytokine producing cells, an effect that can be p
Externí odkaz:
https://doaj.org/article/37de1a9a384e45eba015976455f5d58b
Autor:
Ting-Fang Chou, Ya-Ting Chuang, Wan-Chen Hsieh, Pei-Yun Chang, Hsin-Yu Liu, Shu-Ting Mo, Tzu-Sheng Hsu, Shi-Chuen Miaw, Ruey-Hwa Chen, Adi Kimchi, Ming-Zong Lai
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)
HIF-1α is critical for Th17 differentiation. Here the authors show that DAPK (Death-Associated Protein Kinase) inhibits Th17 differentiation and immunopathology in a mouse model of multiple sclerosis by promoting HIF1-α binding to its negative regu
Externí odkaz:
https://doaj.org/article/760f4386456742798a6a43da19805d86
Autor:
Yung-Hsuan Wu, Shu-Ting Mo, I-Ting Chen, Fu-Yi Hsieh, Shie-Liang Hsieh, Jinake Zhang, Ming-Zong Lai
Publikováno v:
Science Advances. 8
Caspase-8 activity controls the switch from cell death to pyroptosis when apoptosis and necroptosis are blocked, yet how caspase-8 inactivation induces inflammasome assembly remains unclear. We show that caspase-8 inhibition via IETD treatment in Tol
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ac9e387b73cb39369bf98b4d10c3bdb2
https://doi.org/10.1126/sciadv.abn9912
https://doi.org/10.1126/sciadv.abn9912
Autor:
Adi Kimchi, Ruey-Hwa Chen, Leslie Young, Ting-Fang Chou, Shu-Ting Mo, Ming-Zong Lai, Shani Bialik Brown, Hsuan-Yin Pan, Yung-Hsuan Wu, Fu-Yi Hsieh
Publikováno v:
Cell Death and Disease, Vol 11, Iss 5, Pp 1-15 (2020)
Cell Death & Disease
Cell Death & Disease
Death-associated protein kinase 1 (DAPK1, DAPk, DAPK) is known for its involvement in apoptosis and autophagy-associated cell death. Here, we identified an unexpected function of DAPK1 in suppressing necroptosis. DAPK1-deficiency renders macrophages
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::680a601571fbc71da6d3cb6cb9fc057e
http://link.springer.com/article/10.1038/s41419-020-2534-9
http://link.springer.com/article/10.1038/s41419-020-2534-9
Autor:
Yung-Hsuan Wu, Hsiao-Chi Chen, Peng-Yeh Lai, Hsiu-Ming Shih, Yu-Hsun Lo, Fu-Yi Hsieh, Ming-Zong Lai, I-Ting Chen
Publikováno v:
EMBO Reports
Promyelocytic leukemia protein (PML) is a tumor suppressor possessing multiple modes of action, including induction of apoptosis. We unexpectedly find that PML promotes necroptosis in addition to apoptosis, with Pml −/− macrophages being more res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ec95fbc46342be0265b544da54afbe4b
https://pubmed.ncbi.nlm.nih.gov/34633746
https://pubmed.ncbi.nlm.nih.gov/34633746
Autor:
Yi-Ping Hsueh, Ming-Zong Lai, Yi-Chun Shih, Ching-Yen Tsai, Yun-Fen Hung, Chiung-Ya Chen, Ting-Fang Chou, Ting-Fang Wang
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Frontiers in Immunology
Frontiers in Immunology
Toll-like receptor (TLR) signaling is critical for defense against pathogenic infection, as well as for modulating tissue development. Activation of different TLRs triggers common inflammatory responses such as cytokine induction. Here, we reveal dif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083ca3f4488b29cdeebd9b64ed33b577
Publikováno v:
The Febs Journal
Inborn errors of immunity (IEIs) are a group of genetically defined disorders leading to defective immunity. Some IEIs have been linked to mutations of immune receptors or signaling molecules, resulting in defective signaling of respective cascades e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7d084c246a07952cf43d96123dd12c0
https://pubmed.ncbi.nlm.nih.gov/33971084
https://pubmed.ncbi.nlm.nih.gov/33971084
Autor:
Po-Yu Chi, Alan Chuan-Ying Lai, Tzu-Sheng Hsu, Yen-Lin Lin, Shu-Ting Mo, Hsuan-Yin Pan, Ya-Jen Chang, Yu-An Wang, Ming-Zong Lai
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-16 (2020)
Nature Communications
Nature Communications
Hypoxia-inducible factor 1α (HIF-1α) and HIF-2α are master transcription factors that regulate cellular responses to hypoxia, but the exact function in regulatory T (Treg) cells is controversial. Here, we show that Treg cell development is normal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e082d6d32d6747d19225ee61598c93eb
https://doi.org/10.1038/s41467-020-18731-y
https://doi.org/10.1038/s41467-020-18731-y