Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Ming-Yu Fang"'
Autor:
Ming-Yu Fang, Kuan-Hsun Huang, Wei-Ju Tu, Yi-Ting Chen, Pei-Yun Pan, Wan-Chi Hsiao, Yi-Yu Ke, Lun K. Tsou, Mingzi M. Zhang
Publikováno v:
Redox Biology, Vol 46, Iss , Pp 102126- (2021)
Nitro-fatty acids are a class of endogenous electrophilic lipid mediators with anti-inflammatory and cytoprotective effects in a wide range of inflammatory and fibrotic disease models. While these beneficial biological effects of nitro-fatty acids ar
Externí odkaz:
https://doaj.org/article/07ddefb9cb444550933900ccaf1114fd
Synthesis and Evaluation of Small Molecule Drug Conjugates Harnessing Thioester-Linked Maytansinoids
Autor:
Chen-Fu Lo, Tai-Yu Chiu, Yu-Tzu Liu, Li-Rung Huang, Teng-Kuang Yeh, Kuan-Hsun Huang, Kuan-Liang Liu, Chia-Yu Hsu, Ming-Yu Fang, Yu-Chen Huang, Tsu-An Hsu, Chiung-Tong Chen, Lun Kelvin Tsou
Publikováno v:
Pharmaceutics, Vol 14, Iss 7, p 1316 (2022)
Ligand-targeting drug conjugates are a class of clinically validated biopharmaceutical drugs constructed by conjugating cytotoxic drugs with specific disease antigen targeting ligands through appropriate linkers. The integrated linker-drug motif embe
Externí odkaz:
https://doaj.org/article/b45299c01a614df1a2a60ca89927679d
Autor:
Chen-Fu Lo, Tai-Yu Chiu, Yu-Tzu Liu, Pei-Yun Pan, Kuan-Liang Liu, Chia-Yu Hsu, Ming-Yu Fang, Yu-Chen Huang, Teng-Kuang Yeh, Tsu-An Hsu, Chiung-Tong Chen, Li-Rung Huang, Lun Kelvin Tsou
Publikováno v:
Journal of Medicinal Chemistry. 65:12802-12824
Ligand-targeting drug delivery systems have made significant strides for disease treatments with numerous clinical approvals in this era of precision medicine. Herein, we report a class of small molecule-based immune checkpoint-targeting maytansinoid
Autor:
Pei-Yun Pan, Wei-Ju Tu, Yi-Ting Chen, Lun K. Tsou, Wan-Chi Hsiao, Ming-Yu Fang, Mingzi M. Zhang, Kuan-Hsun Huang, Yi-Yu Ke
Publikováno v:
Redox Biology, Vol 46, Iss, Pp 102126-(2021)
Redox Biology
Redox Biology
Nitro-fatty acids are a class of endogenous electrophilic lipid mediators with anti-inflammatory and cytoprotective effects in a wide range of inflammatory and fibrotic disease models. While these beneficial biological effects of nitro-fatty acids ar
Autor:
Mingzi M. Zhang, Ming-Yu Fang, Pei-Yun Pan, Yi-Yu Ke, Yi-Ting Chen, Lun K. Tsou, Wan-Chi Hsiao, Wei-Ju Tu, Kuan-Hsun Huang
Nitro-fatty acids are a class of endogenous electrophilic lipid mediators with anti-inflammatory and cytoprotective effects in a wide range of inflammatory and fibrotic disease models. While these beneficial biological effects of nitro-fatty acids ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1af845a504f52ad0e75f69d2ef6cbf6e
https://doi.org/10.1101/2021.07.12.451990
https://doi.org/10.1101/2021.07.12.451990
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e111331 (2014)
Enterovirus 71 (EV-A71) is a neurotropic virus that can cause severe complications involving the central nervous system. No effective antiviral therapeutics are available for treating EV-A71 infection and drug discovery efforts are rarely focused to
Externí odkaz:
https://doaj.org/article/d26b2c67c7094cff9f0b895be2170a24
Autor:
Kai-Cheng Hsu, Hui-Chen Hung, Jim-Tong Horng, Ming-Yu Fang, Chun-Yu Chang, Ling-Ting Li, I-Jung Chen, Yun-Chu Chen, Ding-Li Chou, Chun-Wei Chang, Hsing-Pang Hsieh, Jinn-Moon Yang, John T-A Hsu
Publikováno v:
PLoS ONE, Vol 8, Iss 2, p e56704 (2013)
Infection with influenza virus is a major public health problem, causing serious illness and death each year. Emergence of drug-resistant influenza virus strains limits the effectiveness of drug treatment. Importantly, a dual H275Y/I223R mutation det
Externí odkaz:
https://doaj.org/article/268a59ab9838414a85c0be9a37a85296
Autor:
Kak-Shan Shia, Wei-Han Chen, Jiing-Jyh Jan, Chien-Huang Wu, Lun K. Tsou, Teng-Kuang Yeh, Yu-Wei Liu, Chen-Fu Lo, Kuan-Liang Liu, Koon Y. Pak, Chen-Lung Huang, Ming-Yu Fang, Tsu-An Hsu, Yu-Chen Huang, Yun-Yu Chen, Chiung-Tong Chen, Yu‐Cheng Yeh, Kuan-Hsun Huang, Brian D. Gray
Publikováno v:
Bioconjugate chemistry. 28(7)
A series of zinc(II) dipicolylamine (ZnDPA)-based drug conjugates have been synthesized to probe the potential of phosphatidylserine (PS) as a new antigen for small molecule drug conjugate (SMDC) development. Using in vitro cytotoxicity and plasma st
Autor:
Sing Yi Wang, Yi-Rong Chen, Ming Yu Fang, Shaik Rafi, Wen-Hsing Lin, Mohane Selvaraj Coumar, Yu-Sheng Chao, John T.A. Hsu, Teng Yuan Chang, Hsing Pang Hsieh, Kai-Chia Yeh, Ching Ping Chen, Chiung-Tong Chen, Chang Ying Chu, Hui Hsu, Chun-Chen Liao, Chun Hwa Chen, Su Huei Hsieh, Tzu Wen Lien, Hui Yi Shiao, Chia Hsien Wu, Teng Kuang Yeh, Chun Yu Chang
Publikováno v:
Journal of Medicinal Chemistry. 53:7316-7326
HTS hit 7 was modified through hybrid design strategy to introduce a chiral side chain followed by introduction of Michael acceptor group to obtain potent EGFR kinase inhibitors 11 and 19. Both 11 and 19 showed over 3 orders of magnitude enhanced HCC
Autor:
John T.A. Hsu, Ming-Yu Fang, Kuei-Jung Yen, Tzu-Chun Chen, Shin-Ru Shih, Ching-Ping Tseng, Hui-Chen Hung
Publikováno v:
Journal of Antimicrobial Chemotherapy
Objectives Enterovirus 71 (EV71) causes serious diseases in humans. The aim of this study was to examine the effects of aurintricarboxylic acid (ATA) on EV71 replication and to explore the underlying mechanism. Methods To measure the activity of ATA