Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Ming-Liang Ji"'
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Ji and colleagues identify Sirt6 as a regulator of chondrocyte senescence. Mechanistically, Sirt6 physically interacts with STAT5 and deacetylates it at K163, which reduces the IL-15/JAK3-induced STAT5 translocation from cytoplasm to nucleus.
Externí odkaz:
https://doaj.org/article/ed230d0419104070aa1ffb2a7c0f62e6
Autor:
Ming-liang Ji, Hua Jiang, Xue-jun Zhang, Pei-liang Shi, Chao Li, Hao Wu, Xiao-tao Wu, Yun-tao Wang, Chen Wang, Jun Lu
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
Intervertebral disk degeneration (IDD) is characterized by changes in the nucleus pulposus (NP) extra cellular matrix that compromise disk structural integrity. In a miRNA screen of human IDD patient NP tissue, the authors identify deregulated miR-14
Externí odkaz:
https://doaj.org/article/5af4fa98c3074207be1a611a2bff2f4b
Publikováno v:
Am J Hum Genet
Epigenetic reprogramming plays a critical role in chondrocyte senescence during osteoarthritis (OA) pathology, but the underlying molecular mechanisms remain to be elucidated. Here, using large-scale individual datasets and genetically engineered (Co
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bcd8205c7e64955af9c159c858086a58
https://europepmc.org/articles/PMC10119164/
https://europepmc.org/articles/PMC10119164/
Epigenetic reprogramming plays a critical role in chondrocyte senescence during osteoarthritis (OA) pathology, but the underlying molecular mechanisms remain to be elucidated. Here using large-scale patient data sets and genetically engineered (Col2a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8763adfdcee159b2fc56ea66a05a3a94
https://doi.org/10.21203/rs.3.rs-1645805/v1
https://doi.org/10.21203/rs.3.rs-1645805/v1
Publikováno v:
Molecular Medicine Reports. 22:2123-2131
Osteoarthritis (OA) is one of the most common degenerative disease in elderly patients worldwide. Numerous microRNAs (miRs) have been reported to serve an important role in the regulation of gene expression in the occurrence and development of OA. Th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7a831ee80760916c25252c57e34863df
https://doi.org/10.3892/mmr.2020.11289
https://doi.org/10.3892/mmr.2020.11289
Autor:
Rui Geng, Jun Lu, Xiao Tao Wu, Fei Wu, Ming-liang Ji, Li kun Ya, Yu Cheng Lin, Ji Hao Xu, Hua Jiang
Publikováno v:
Annals of the rheumatic diseases. 80(3)
ObjectivesDespite preclinical studies involving miRNA therapeutics conducted in osteoarthritis (OA) over the years, none of these miRNAs have yet translated to clinical applications, owing largely to the lack of efficient intra-articular (IA) deliver
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d07ec1b48ee0c2224ca2d594b56ff2e4
https://pubmed.ncbi.nlm.nih.gov/33109602
https://pubmed.ncbi.nlm.nih.gov/33109602
Autor:
Atiyayein A. Wallace, Sujun Qiu, Richard Ripper, Fackson Mwale, Hee Jeong Im, In Sug O-Sullivan, Gina Votta-Velis, Bingqian Zhu, Andre J. van Wijnen, Jeffrey S. Kroin, Vaskar Das, Changgui Shi, Lan Zhao, Jun Lu, Xin Li, Ranjan Kc, Ming-liang Ji, Wen Yuan
Publikováno v:
Journal of Cellular Physiology. 233:6589-6602
Discogenic low back pain (DLBP) is extremely common and costly. Effective treatments are lacking due to DLBP's unknown pathogenesis. Currently, there are no in vivo mouse models of DLBP, which restricts research in this field. The aim of this study w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0dadb4b143c1075829f282db08625fe
https://doi.org/10.1002/jcp.26280
https://doi.org/10.1002/jcp.26280
Autor:
Ming-Liang Ji, Hua Jiang, Fei Wu, Rui Geng, Li kun Ya, Yu Cheng Lin, Ji Hao Xu, Xiao Tao Wu, Jun Lu, Ji, Ming-Liang, Jiang, Hua, Wu, Fei, Geng, Rui, Ya, Li Kun, Lin, Yu Cheng, Xu, Ji Hao, Wu, Xiao Tao, Lu, Jun
Publikováno v:
Annals of the Rheumatic Diseases; Mar2021, Vol. 80 Issue 3, p356-366, 11p
Publikováno v:
Molecular Therapy. 25:2676-2688
Emerging evidence suggests that dysregulated microRNAs (miRNAs) play a pivotal role in osteoarthritis (OA), but the role of specific miRNAs remains unclear. Accordingly, we identified OA-associated miRNAs and functional validation of results. Here, w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc1096618763c8edc8bf085c0d7db410
https://doi.org/10.1016/j.ymthe.2017.08.009
https://doi.org/10.1016/j.ymthe.2017.08.009
Publikováno v:
Clinical Spine Surgery: A Spine Publication. 30:328-334
Study Design: A prospective magnetic resonance imaging study. Objective: To quantitatively explore the differences in the anatomic position of the aorta relative to the spine between supine and prone positions in ankylosing spondylitis (AS) patients
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3e055f69cdf7fc8df00ef57e5aedcf6d
https://doi.org/10.1097/bsd.0000000000000304
https://doi.org/10.1097/bsd.0000000000000304