Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Ming-Kuan Chyan"'
Autor:
Yawen Li, Donald K Hamlin, Ming-Kuan Chyan, Roger Wong, Eric F Dorman, Robert C Emery, Douglas R Woodle, Ronald L Manger, Margaret Nartea, Aimee L Kenoyer, Johnnie J Orozco, Damian J Green, Oliver W Press, Rainer Storb, Brenda M Sandmaier, D Scott Wilbur
Publikováno v:
PLoS ONE, Vol 13, Iss 10, p e0205135 (2018)
The objective of this study was to translate reaction conditions and quality control methods used for production of an astatine-211(211At)-labeled anti-CD45 monoclonal antibody (MAb) conjugate, 211At-BC8-B10, from the laboratory setting to cGMP produ
Externí odkaz:
https://doaj.org/article/cbfd877a8a544580afae3b17128483ad
Publikováno v:
International journal of molecular sciences. 23(18)
The alpha particle-emitting radionuclide astatine-211 (
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::21cc1821059ed6e5e485301673629f9c
https://pubmed.ncbi.nlm.nih.gov/36142567
https://pubmed.ncbi.nlm.nih.gov/36142567
Autor:
Shigeki Watanabe, D. Scott Wilbur, Sujit Pal, Ming-Kuan Chyan, Ethan R. Balkin, Donald K. Hamlin, Katherine Gagnon
Publikováno v:
Applied Sciences, Vol 3, Iss 3, Pp 636-655 (2013)
A “wet chemistry” approach for isolation of 211At from an irradiated bismuth target is described. The approach involves five steps: (1) dissolution of bismuth target in conc. HNO3; (2) removal of the HNO3 by distillation; (3) dissolution of resid
Externí odkaz:
https://doaj.org/article/75b00fbba95f4b73a0d9a0c4fb3fb92e
Autor:
Emily K. Kirkeby, Ming-Kuan Chyan, George Diehl, D. Scott Wilbur, Yawen Li, Andrew G. Roberts, Tara Mastren
Publikováno v:
Applied Radiation and Isotopes. 191:110555
Alzheimer's disease (AD) is a terminal neurodegenerative disease characterized by the buildup of amyloid fibrils, amorphous aggregates and tauopathies. Several treatment modalities, which rely on various biological processes to reduce disease burden,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::816a1538ee6490505b37d039f298c691
https://doi.org/10.1016/j.apradiso.2022.110555
https://doi.org/10.1016/j.apradiso.2022.110555
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 18; Pages: 10655
The alpha particle-emitting radionuclide astatine-211 (211At) is of interest for targeted radiotherapy; however, low in vivo stability of many 211At-labeled cancer-targeting molecules has limited its potential. As an alternative labeling method, we e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a4c3dc7c5a250310143a093a7bdb5b77
https://doi.org/10.3390/ijms231810655
https://doi.org/10.3390/ijms231810655
Autor:
Tara Mastren, Donald K. Hamlin, Chris Orvig, Michael E. Fassbender, Ming-Kuan Chyan, Lily Li, Roger Wong, Maryline G. Ferrier, Yawen Li, D. Scott Wilbur, Sarah Spreckelmeyer
Publikováno v:
Journal of labelled compoundsradiopharmaceuticalsREFERENCES. 63(12)
One of the main challenges in targeted alpha therapy is assuring delivery of the α-particle dose to the targeted cells. Thus, it is critical to identify ligands for α-emitting radiometals that will form complexes that are very stable, both in vitro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::284de6e46b2bdaea6b449fef71804da2
https://pubmed.ncbi.nlm.nih.gov/32812275
https://pubmed.ncbi.nlm.nih.gov/32812275
Autor:
Robert L. Vessella, Ming-Kuan Chyan, D. Scott Wilbur, Holly M. Nguyen, Yawen Li, Donald K. Hamlin
Publikováno v:
Nucl Med Biol
Introduction The use of lysine-urea-glutamate (LuG) for targeting the PSMA antigen on prostate cancer (PCa) is a promising method for delivering the alpha particle-emitting radionuclide astatine-211 (211At) to metastatic PCa. High kidney localization
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1848481d05d1ab581369c587778ce02b
https://pubmed.ncbi.nlm.nih.gov/32409263
https://pubmed.ncbi.nlm.nih.gov/32409263
Autor:
Taylor M. Morscheck, Ming-Kuan Chyan, D. Scott Wilbur, Donald K. Hamlin, Yawen Li, Maryline G. Ferrier, Roger Wong
Publikováno v:
Scientific Reports
Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
Scientific Reports, Vol 9, Iss 1, Pp 1-7 (2019)
Astatine-211 is an attractive radionuclide for use in targeted alpha therapy of blood-borne diseases and micrometastatic diseases. Efficient isolation methods that can be adapted to robust automated 211At isolation systems are of high interest for im
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::00f62a576cb80dcb9659dbe37cc7a60f
https://doi.org/10.1038/s41598-019-53385-x
https://doi.org/10.1038/s41598-019-53385-x
Autor:
D. Scott Wilbur, James Guthrie, Silvia S. Jurisson, Ming-Kuan Chyan, Firouzeh Najafi Khosroshahi, Eric Dorman, Anster Charles, Yawen Li, Roger Wong, Cathy S. Cutler, Heather M. Hennkens, Dmitri Medvedev, Jack Lydon
Publikováno v:
Nuclear Medicine and Biology. :S104
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1a116ff64e33d7fb6b40b1ecc6b9a9fb
https://doi.org/10.1016/s0969-8051(21)00440-6
https://doi.org/10.1016/s0969-8051(21)00440-6
Autor:
D. Scott Wilbur, Donald K. Hamlin, Robert Emery, Damian J. Green, Ronald L Manger, Brenda M. Sandmaier, Margaret E. Nartea, Roger Wong, Douglas R Woodle, Aimee L. Kenoyer, Eric Dorman, Ming-Kuan Chyan, Johnnie J. Orozco, Rainer Storb, Yawen Li, Oliver W. Press
Publikováno v:
PLoS ONE
PLoS ONE, Vol 13, Iss 10, p e0205135 (2018)
PLoS ONE, Vol 13, Iss 10, p e0205135 (2018)
The objective of this study was to translate reaction conditions and quality control methods used for production of an astatine-211(211At)-labeled anti-CD45 monoclonal antibody (MAb) conjugate, 211At-BC8-B10, from the laboratory setting to cGMP produ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::91a7179fd85942352901fe62e6959ab4
https://pubmed.ncbi.nlm.nih.gov/30335787
https://pubmed.ncbi.nlm.nih.gov/30335787