Zobrazeno 1 - 10
of 265
pro vyhledávání: '"Ming-Kai Chen"'
Publikováno v:
BMC Anesthesiology, Vol 24, Iss 1, Pp 1-8 (2024)
Abstract Introduction Postoperative nausea and vomiting (PONV) is one of the most common adverse events following orthognathic surgery. It’s a distressing feeling for patients and continues to be the cause of postoperative complications such as ble
Externí odkaz:
https://doaj.org/article/a19b0437b5674edb8771718e06c87a24
Autor:
Xiang Lin, Ji-Dong Chen, Chen-Yu Wang, Zhen Cai, Rui Zhan, Chen Yang, La-Ying Zhang, Lian-Yun Li, Yong Xiao, Ming-Kai Chen, Min Wu
Publikováno v:
Genome Biology, Vol 24, Iss 1, Pp 1-23 (2023)
Abstract Background Enhancer dysregulation is one of the important features for cancer cells. Enhancers enriched with H3K4me3 have been implicated to play important roles in cancer. However, their detailed features and regulatory mechanisms have not
Externí odkaz:
https://doaj.org/article/c20e6f648f3c43ceabd35c01027de249
Autor:
Mika Naganawa, Jean-Dominique Gallezot, Sjoerd J. Finnema, Ralph Paul Maguire, Joël Mercier, Nabeel B. Nabulsi, Sophie Kervyn, Shannan Henry, Jean-Marie Nicolas, Yiyun Huang, Ming-Kai Chen, Jonas Hannestad, Henrik Klitgaard, Armel Stockis, Richard E. Carson
Publikováno v:
EJNMMI Research, Vol 12, Iss 1, Pp 1-11 (2022)
Abstract Background Antiepileptic drugs, levetiracetam (LEV) and brivaracetam (BRV), bind to synaptic vesicle glycoprotein 2A (SV2A). In their anti-seizure activity, speed of brain entry may be an important factor. BRV showed faster entry into the hu
Externí odkaz:
https://doaj.org/article/22d2f1f3be124f3691b641c2f77893e1
Autor:
Ryan S. O'Dell, Albert Higgins-Chen, Dhruva Gupta, Ming-Kai Chen, Mika Naganawa, Takuya Toyonaga, Yihuan Lu, Gessica Ni, Anna Chupak, Wenzhen Zhao, Elaheh Salardini, Nabeel B. Nabulsi, Yiyun Huang, Amy F.T. Arnsten, Richard E. Carson, Christopher H. van Dyck, Adam P. Mecca
Publikováno v:
NeuroImage: Clinical, Vol 39, Iss , Pp 103457- (2023)
Background: Synaptic loss is considered an early pathological event and major structural correlate of cognitive impairment in Alzheimer’s disease (AD). We used principal component analysis (PCA) to identify regional patterns of covariance in synapt
Externí odkaz:
https://doaj.org/article/14ed4c06b1984adc816314ca9ad18e33
Autor:
Lin Chen, Zhihui Luo, Chen Zhao, Qinglan Li, Yingjie Geng, Yong Xiao, Ming‐Kai Chen, Lianyun Li, Zhen‐Xia Chen, Min Wu
Publikováno v:
Advanced Science, Vol 9, Iss 23, Pp n/a-n/a (2022)
Abstract Inflammation is one of the critical risk factors for colorectal cancer (CRC). However, the mechanisms for transition from colitis to CRC remain elusive. Recently, epigenetic changes have emerged as important regulatory factors for colitis‐
Externí odkaz:
https://doaj.org/article/677ae405d97045818513c457027b152a
Autor:
Wei-Wei Yao, Ran Li, Hao Chen, Ming-Kai Chen, Yu-Xin Luan, Yi Wang, Zhi-Xiang Yu, Mengchun Ye
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-9 (2021)
Allylic amines are versatile building blocks in organic synthesis and exist in bioactive compounds, but efficient catalytic systems for hydroaminoalkylation of alkynes are needed. Here, the authors report a late transition metal‐catalyzed hydroamin
Externí odkaz:
https://doaj.org/article/95db0d7dc8c1444695587f731b4b144f
Autor:
Ryan S. O’Dell, Adam P. Mecca, Ming-Kai Chen, Mika Naganawa, Takuya Toyonaga, Yihuan Lu, Tyler A. Godek, Joanna E. Harris, Hugh H. Bartlett, Emmie R. Banks, Victoria L. Kominek, Wenzhen Zhao, Nabeel B. Nabulsi, Jim Ropchan, Yunpeng Ye, Brent C. Vander Wyk, Yiyun Huang, Amy F. T. Arnsten, Richard E. Carson, Christopher H. van Dyck
Publikováno v:
Alzheimer’s Research & Therapy, Vol 13, Iss 1, Pp 1-12 (2021)
Abstract Background Attempts to associate amyloid-β (Aβ) pathogenesis with synaptic loss in Alzheimer’s disease (AD) have thus far been limited to small numbers of postmortem studies. Aβ plaque burden is not well-correlated with indices of clini
Externí odkaz:
https://doaj.org/article/bf54db7ecf0047c889104bb1723e1147
Autor:
Adam P. Mecca, Julia W. McDonald, Hannah R. Michalak, Tyler A. Godek, Joanna E. Harris, Erika A. Pugh, Emily C. Kemp, Ming-Kai Chen, Arash Salardini, Nabeel B. Nabulsi, Keunpoong Lim, Yiyun Huang, Richard E. Carson, Stephen M. Strittmatter, Christopher H. van Dyck
Publikováno v:
Alzheimer’s Research & Therapy, Vol 12, Iss 1, Pp 1-10 (2020)
Abstract Background Metabotropic glutamate subtype 5 receptors (mGluR5) modulate synaptic transmission and may constitute an important therapeutic target in Alzheimer’s disease (AD) by mediating the synaptotoxic action of amyloid-β oligomers. We u
Externí odkaz:
https://doaj.org/article/fea1a7ff0aba43c19ea7e0af4b8ca35a
Autor:
Yihuan Lu, Takuya Toyonaga, Mika Naganawa, Jean-Dominique Gallezot, Ming-Kai Chen, Adam P. Mecca, Christopher H. van Dyck, Richard E. Carson
Publikováno v:
NeuroImage, Vol 238, Iss , Pp 118248- (2021)
Purpose: 11C-UCB-J PET imaging, targeting synaptic vesicle glycoprotein 2A (SV2A), has been shown to be a useful indicator of synaptic density in Alzheimer's disease (AD). For SV2A imaging, a decrease in apparent tracer uptake is often due to the com
Externí odkaz:
https://doaj.org/article/1b130473ba4e412bbffdd545c6e6b04d
Autor:
Tianshun Miao, Bo Zhou, Juan Liu, Xueqi Guo, Qiong Liu, Huidong Xie, Xiongchao Chen, Ming-Kai Chen, Jing Wu, Richard E. Carson, Chi Liu
Publikováno v:
IEEE Transactions on Radiation and Plasma Medical Sciences. 7:465-472