Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Ming-Ji Fann"'
Autor:
Monika Nováková, Marek Hampl, Dávid Vrábel, Jan Procházka, Silvia Petrezselyová, Michaela Procházková, Radislav Sedláček, Michaela Kavková, Tomáš Zikmund, Jozef Kaiser, Hsien-Chia Juan, Ming-Ji Fann, Marcela Buchtová, Jiří Kohoutek
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 7 (2019)
Congenital heart defects, dysmorphic facial features and intellectual developmental disorders (CHDFIDD) syndrome in humans was recently associated with mutation in CDK13 gene. In order to assess the loss of function of Cdk13 during mouse development,
Externí odkaz:
https://doaj.org/article/4d41af9129ff4519a62d72b8f5b0b1e8
Autor:
Huey-Jiun Ko, Shean-Jaw Chiou, Yu-Hui Wong, Yin-Hsuan Wang, Yun-Ling Lai, Chia-Hua Chou, Chihuei Wang, Joon-Khim Loh, Ann-Shung Lieu, Jiin-Tsuey Cheng, Yu-Te Lin, Pei-Jung Lu, Ming-Ji Fann, Chi-Ying Huang, Yi-Ren Hong
Publikováno v:
Journal of Clinical Medicine, Vol 8, Iss 10, p 1751 (2019)
Based on the protein kinase A (PKA)/GSK3β interaction protein (GSKIP)/glycogen synthase kinase 3β (GSK3β) axis, we hypothesized that these might play a role in Tau phosphorylation. Here, we report that the phosphorylation of Tau Ser409 in SHSY5Y c
Externí odkaz:
https://doaj.org/article/e34e5700f3684d8b8b41fea09566fb9e
Autor:
Shih Wei Chen, Yeh Shiu Chu, Nien-Jung Chen, Jong Ling Fuh, Shu Cian Chen, Ming-Ji Fann, Yu Hui Wong, Yu Sheng Hung
Publikováno v:
Stem Cell Reports
Summary Microglia, the immune cells of the central nervous system, play critical roles in brain physiology and pathology. We report a novel approach that produces, within 10 days, the differentiation of human induced pluripotent stem cells (hiPSCs) i
Autor:
Tu Thanh Tran, Young Ji Shiao, Irene Han Juo Cheng, Shu Cian Chen, Lung Sen Kao, Shuu Jiun Wang, Cheng Chang Lien, Jong Ling Fuh, Ming-Ji Fann, Yu Hui Wong, Chi Ying F. Huang, Pei Chun Wu, Tania Devina, Tsai Teng Tzeng
Publikováno v:
Scientific Reports, Vol 9, Iss 1, Pp 1-15 (2019)
Scientific Reports
Scientific Reports
Alzheimer’s disease (AD) is the most common type of dementia and also one of the leading causes of death worldwide. However, the underlying mechanisms remain unclear, and currently there is no drug treatment that can prevent or cure AD. Here, we ha
Autor:
Chihuei Wang, Joon Khim Loh, Yin Hsuan Wang, Yu Te Lin, Huey Jiun Ko, Pei Jung Lu, Ann Shung Lieu, Jiin Tsuey Cheng, Ming-Ji Fann, Shean Jaw Chiou, Yu Hui Wong, Chia Hua Chou, Yi Ren Hong, Yun Ling Lai, Chi Ying F. Huang
Publikováno v:
Journal of Clinical Medicine
Volume 8
Issue 10
Journal of Clinical Medicine, Vol 8, Iss 10, p 1751 (2019)
Volume 8
Issue 10
Journal of Clinical Medicine, Vol 8, Iss 10, p 1751 (2019)
Based on the protein kinase A (PKA)/GSK3&beta
interaction protein (GSKIP)/glycogen synthase kinase 3&beta
(GSK3&beta
) axis, we hypothesized that these might play a role in Tau phosphorylation. Here, we report that the phosphorylation
interaction protein (GSKIP)/glycogen synthase kinase 3&beta
(GSK3&beta
) axis, we hypothesized that these might play a role in Tau phosphorylation. Here, we report that the phosphorylation
Publikováno v:
Cell Death and Differentiation
The maintenance of genomic integrity during early embryonic development is important in order to ensure the proper development of the embryo. Studies from cultured cells have demonstrated that cyclin-dependent kinase 12 (Cdk12) is a multifunctional p
Publikováno v:
Alzheimer's & Dementia. 15:P1495-P1496
Autor:
Chin Yin Tai, Lei Li Li, Ming-Ji Fann, Chen-Jee Hong, Bo Shiun Ren, Fang Shin Nian, Lung Sen Kao, Pei Chun Wu, Chih Ya Cheng, You Tai Lin, Jin Wu Tsai, Cheng Yung Tang
Publikováno v:
Molecular neurobiology. 56(9)
Mutations in RAB18, a member of small G protein, cause Warburg micro syndrome (WARBM), whose clinical features include vision impairment, postnatal microcephaly, and lower limb spasticity. Previously, our Rab18-/- mice exhibited hind limb weakness an
Publikováno v:
Experimental Neurology. 261:10-21
Cdk12 and Cdk13 are Cdc2-related proteins that share 92% identity in their kinase domains. Using in situ hybridization and Western blot analysis, we detected the expression of Cdk12 and Cdk13 mRNAs and their proteins in developing mouse embryos, espe
Publikováno v:
Cerebral cortex (New York, N.Y. : 1991). 27(3)
DNA damage response (DDR) pathways are critical for ensuring that replication stress and various types of DNA lesion do not perturb production of neural cells during development. Cdk12 maintains genomic stability by regulating expression of DDR genes