Výsledky vyhledávání - "Ming-Biao Yin"

Downregulation of Cystine Transporter xc– by Irinotecan in Human Head and Neck Cancer FaDu Xenografts

Autor: Farukh A. Durrani, Karoly Toth, Tanjima R. Zinia, Sylvia B. Smith, Ming Biao Yin, Youcef M. Rustum, Shousong Cao, Sreenivasulu Chintala, Arup Bhattacharya, Rebecca Dean, M. Shamsul Ola, Harry K. Slocum

Publikováno v: Chemotherapy. 56:223-233

Background: The purpose of this study was: (1) to document the critical requirement of cystine for growth of human tumor cells in vitro, and (2) to determine the effect of the anticancer agent irinotecan on the cystine transporter xc– in head and n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96a47bdadafe57a5728289e4e1fc7d81
https://doi.org/10.1159/000316334

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Potentiation of irinotecan sensitivity by Se-methylselenocysteine in an in vivo tumor model is associated with downregulation of cyclooxygenase-2, inducible nitric oxide synthase, and hypoxia-inducible factor 1α expression, resulting in reduced angiogenesis

Autor: Ming-Biao Yin, Gunnar Hapke, Rami G. Azrak, Karoly Toth, Arup Bhattacharya, Cheryl Frank, Li Zr, Farukh A. Durrani, Shousong Cao, Y. M. Rustum

Publikováno v: Oncogene. 25:2509-2519

Until recently, the use of Se-methylselenocysteine (MSC) as selective modulator of the antitumor activity and selectivity of anticancer drugs including irinotecan, a topoisomerase I poison, had not been evaluated. Therapeutic synergy between MSC and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a9f6fc03c7b30148fc8a34682439de59
https://doi.org/10.1038/sj.onc.1209073

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Enhanced 7-Ethyl-10-hydroxycamptothecin (SN-38) Lethality by Methylselenocysteine Is Associated with Chk2 Phosphorylation at Threonine-68 and Down-Regulation of Cdc6 Expression

Autor: Rami G. Azrak, Youcef M. Rustum, Farukh A. Durrani, Zhan-Rong Li, Ming-Biao Yin, Cheryl Frank, Shousong Cao

Publikováno v: Molecular Pharmacology. 66:153-160

Methylselenocysteine (MSC) is an organic selenium compound in preventative clinical trials involving prostate, lung, and colon carcinoma. We found that methioninase-activated MSC potentiates 7-ethyl-10-hydroxycamptothecin (SN-38)-induced cell lethali

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d86aaaef2eea80cf6ec460858ca22d0
https://doi.org/10.1124/mol.66.1.153

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Chk1 signaling pathways that mediated G2M checkpoint in relation to the cellular resistance to the novel topoisomerase I poison BNP1350

Autor: Ming-Biao Yin, Carol Wrzosek, Rami G. Azrak, Cheryl Frank, Gunnar Hapke, Youcef M. Rustum, Jiaxi Wu

Publikováno v: Biochemical and Biophysical Research Communications. 295:435-444

A novel karenitecin, BNP1350, is a topoisomerase I-targeting anticancer agent with significant antitumor activity in vitro and in vivo. A BNP1350-resistant human head and neck carcinoma A253 cell line, denoted A253/BNPR, was developed. The A253/BNPR

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c92d0efd8105343339180ec5ce2d67
https://doi.org/10.1016/s0006-291x(02)00683-6

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The Chk1-Cdc25C regulation is involved in sensitizing A253 cells to a novel topoisomerase I inhibitor BNP1350 by bax gene transfer

Autor: Ming-Biao Yin, Gunnar Hapke, Youcef M. Rustum, Rami G. Azrak, Bin Guo, Cheryl Frank

Publikováno v: Oncogene. 20:5249-5257

Promotion of apoptosis may potentiate the sensitivity of tumor cells to chemotherapeutic agents, thus improving the efficacy of cancer treatment. The transfection of the proapoptotic bax gene, which results in the overexpression of bax protein, augme

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e214e8394dfe423d209769e126773ccf
https://doi.org/10.1038/sj.onc.1204686

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[Untitled]

Autor: Ming-Biao Yin, Youcef M. Rustum, Gunnar Hapke

Publikováno v: Cancer and Metastasis Reviews. 20:109-115

The common clinical problem in the successful treatment of cancer is the resistance of cancer cells to chemotherapeutic drugs. Chemotherapy kills drug-sensitive cells, but leaves behind a higher proportion of drug-resistant cells. The resistance can

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::96c5e3811de6fddea206e5fe85c1614b
https://doi.org/10.1023/a:1013116826788

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Characterization of Protein Kinase chk1 Essential for the Cell Cycle Checkpoint after Exposure of Human Head and Neck Carcinoma A253 Cells to a Novel Topoisomerase I Inhibitor BNP1350

Autor: Hans Minderman, Carol Wrzosek, Youcef M. Rustum, Cheryl Frank, Rami G. Azrak, Udo Vanhoefer, Harry K. Slocum, Bin Guo, Ming-Biao Yin

Publikováno v: Molecular Pharmacology. 57:453-459

Cellular topoisomerase I is an important target in cancer chemotherapy. A novel karenitecin, BNP1350, is a topoisomerase I-targeting anticancer agent with significant antitumor activity against human head and neck carcinoma A253 cells in vitro. As a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11610bc75e456e3c16e116aa2db625d7
https://doi.org/10.1124/mol.57.3.453

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Involvement of cyclin d1-cdk5 overexpression and mcm3 cleavage in bax-associated spontaneous apoptosis and differentiation in an a253 human head and neck carcinoma xenograft model

Autor: Karoly Toth, Ming-Biao Yin, Bin Guo, Harry K. Slocum, Youcef M. Rustum, Shousong Cao, Cheryl Frank

Publikováno v: International Journal of Cancer. 83:341-348

Time-dependent ladder-type DNA fragmentation and morphological alterations consistent with apoptosis were observed among A253 human head and neck squamous cell carcinoma (HNSCC) cells in nude mice from 15 to 18 days after transplantation, without any

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8a91af6e339ba1b207ee16b405e6ec5e
https://doi.org/10.1002/(sici)1097-0215(19991029)83:3<341::aid-ijc9>3.0.co

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Novel cellular determinants for reversal of multidrug resistance in cells expressing P170-glycoprotein

Autor: Cheryl Frank, Wieland Voigt, Ming-Biao Yin, Bin Guo, John F. Gibbs, Youcef M. Rustum, Udo Vanhoefer, Carol Wrzosek, Basil S. Skenderis

Publikováno v: Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1401(3):265-276

The newly synthesized calcium channel blocker, Ro44-5912, significantly potentiates doxorubicin (Dox)-induced cytotoxicity at non-cytotoxic concentrations in Dox-resistant human ovarian cell line, A2780/DX5, overexpressing P170-glycoprotein (Pgp). In

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p53 and WAF1 Are Induced and Rb Protein Is Hypophosphorylated during Cell Growth Inhibition by the Thymidylate Synthase Inhibitor ZD1694 (Tomudex)

Autor: Sanja Pajovic, Wieland Voigt, Jane Clifford Azizkhan, Cheryl Frank, Ming-Biao Yin, Youcef M. Rustum, Angeles Panadero, Udo Vanhoefer

Publikováno v: Molecular Pharmacology. 51:630-636

In a previous study, we found that treatment of HCT-8 cells with ZD1694, a specific antifolate-based thymidylate synthase inhibitor, resulted in DNA fragmentation. In this study, we have demonstrated the dose- and time-dependent induction of DNA frag

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5c54c4ac8a302a3cd320186f7b5dc02
https://doi.org/10.1124/mol.51.4.630

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