Intravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial

Autor: Bijoy K Menon, Brian H Buck, Nishita Singh, Yan Deschaintre, Mohammed A Almekhlafi, Shelagh B Coutts, Sibi Thirunavukkarasu, Houman Khosravani, Ramana Appireddy, Francois Moreau, Gord Gubitz, Aleksander Tkach, Luciana Catanese, Dar Dowlatshahi, George Medvedev, Jennifer Mandzia, Aleksandra Pikula, Jai Shankar, Heather Williams, Thalia S Field, Alejandro Manosalva, Muzaffar Siddiqui, Atif Zafar, Oje Imoukhuede, Gary Hunter, Andrew M Demchuk, Sachin Mishra, Laura C Gioia, Shirin Jalini, Caroline Cayer, Stephen Phillips, Elsadig Elamin, Ashkan Shoamanesh, Suresh Subramaniam, Mahesh Kate, Gregory Jacquin, Marie-Christine Camden, Faysal Benali, Ibrahim Alhabli, Fouzi Bala, MacKenzie Horn, Grant Stotts, Michael D Hill, David J Gladstone, Alexandre Poppe, Arshia Sehgal, Qiao Zhang, Brendan Cord Lethebe, Craig Doram, Ayoola Ademola, Michel Shamy, Carol Kenney, Tolulope T Sajobi, Richard H Swartz, Abhilekh Srivastava, Ahmed M Aljammaz, Akintomide Femi Akindotun, Albert Y Jin, Alexander Fraser, Alexander V Khaw, Alexandru Lemnaru, Alisia Southwell, Alnar Ramji, Alonso Alvarado-Bolaños, Amr Mouminah, Amro B Lahlouh, Amy Y Yu, Anas Alrohimi, Andre Lavoie, Andrea Rogge, Andrew Micieli, Andrew Linh Nguyen, Angelique Callaghan-Brown, Anita Florendo-Cumbermack, Ankur Wadhwa, Ann-Marie Beaudoin, Anne Cayley, Anne Marie Liddy, Anurag Trivedi, Aristeidis H Katsanos, Ashfaq Shuaib, Asif Javed Butt, Olena Bereznyakova, Beth Beauchamp, Breane Mahlitz, Brett R Graham, Brian Dewar, Bryce A Durafourt, Caitlin Holtby, Caitlin S Jackson-Tarlton, Caitlyn Bockus, Caroline Stephenson, Camille Galloway, Céline Odier, Charles Deacon, Charlotte Zerna, Chetan C Vekhande, Christian Bocti, Christian Stapf, Christine Hawkes, Christine Anne Stables, Chrysi Bogiatzi, Claudia Rodriguez, Claudia Candale-Radu, Colleen Murphy, Courtney Sarah Casserly, Daniel Fok, Danielle de Sa Boasquevisque, Daryl Wile, David Volders, Demetrios J Sahlas, Elaine Shand, Elena Adela Cora, Eliane Di Battista, Eileen Stewart, Emily Junk, Emma L Harrison, Eric Frenette, Ericka Teleg, Eslam Abdellah, Esseddeeg Ghrooda, Farhana Akthar, François Evoy, Gary M Klein, Genoveva Maclean, Glen C Jickling, Glenda Hawthorne, Gordon Boyd, Gregory Walker, Gustavo Saposnik, H Lee Lau, Hanan E Badr, Hassanain Toma, Hayrapet Kalashyan, Hugo Marion-Moffet, Ian Grant, Idris Fatakdawala, Isabelle Beaulieu-Boire, Janice Williams, Jaskiran Brar, Jean Rivest, Jeffrey Z Wang, Jessica Dawe, Jillian Stang, Joanne Day, Jodi Miller, Johnathon Gorman, Julia Jasmine Hopyan, Julian Lee, Julie Kromm, Kaitlyn Foster, Kanchana Ratnayake, Kanjana S Perera, Karina Villaluna Murray, Karla Ryckborst, Katie Lin, Kayla Sage, Keithan Sivakuma, Kelly A MacDonald, Kelvin Kuan Ng, Ketki Merchant, Khurshid Khan, Kimia Ghavami, Kyra Johnston, Lauren M Mai, Leah White, Lee Barratt, Linda Longpre, Lisa Crellin, Lissa Peeling, Lori Piquette, Lysa Boissé Lomax, Mahsa Sadeghi, Maneesha Kamra, Manuel Lavoie-April, Margaret Moores, Maria Bres Bullrich, Marie McClelland, Marina Salluzzi, Mark Wilcox, Mark I Boulos, Martha Marko, Matthew Boyko, Maude Lantagne-Hurtubise, May Adel AlHamid, Mays Shawawrah, Michael E Kelly, Michael W D Thorne, Miguel Bussiere, Ming Yin Dominc Tse, Mowad Benguzzi, Mukul Sharma, Myles Horton, Nancy Newcommon, Nandy-Shelwine Simon, Natalie E Parks, Nazeem Sultan, Nevena Markovic, Nicole Daneault, Noman Ishaque, Paige Fairall, Pawel B Kostyrko, Peter K Stys, Philip Teal, Philippe Couillard, Princess King-Azote, Quentin Collier, Rachel Epp, Radhika Nair, Raed A Joundi, Rajive Jassal, Raphael Schneider, Reza Hosseini, Rosalie Bouchard, Ruth Whelan, S Regan Cooley, Sajeevan Sujanthan, Salman Mansoor, Samuel Yip, Sanchea Wasyliw, Sean W. Taylor, Sebastian Friedman, Sharan Mann, Sharleen Weese Maley, Sherry Chiasson, Sherry Xueying Hu, Shorog Althubait, Shuhira Himed, Shuo Chen, Simerpreet S Bal, Stacey A Page, Stacey D Beck, Stephanie Woodroffe, Stephanie D Reiter, Stephen van Gaal, Steven Ray Peters, Sultan Darvesh, Supriya Save, Susan Alcock, Susannah Piercey, Suzie Adam, Sylvie Gosselin, Tess Fitzpatrick, Thomas-Louis Perron, Tim Stewart, Timothy J Benstead, Vishaya Naidoo, Wasan Abd Wahab, Wiesław Oczkowski, William Kingston, William Leduc, William T H To, Yeyao Joe Yu, Zhongyu A Liu, Ziad Ezzat Aljundi

Publikováno v: Lancet (London, England). 400(10347)

Intravenous thrombolysis with alteplase bolus followed by infusion is a global standard of care for patients with acute ischaemic stroke. We aimed to determine whether tenecteplase given as a single bolus might increase reperfusion compared with this

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddc5e53429743ba8fd155e21c582c468
https://pubmed.ncbi.nlm.nih.gov/35779556