Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Ming Y. Chu"'
Publikováno v:
Biochemical Pharmacology. 34:361-367
5′-Deoxy-5′-halogenated adenosines are alternative substrates for 5′-deoxy-5′-methylthioadenosine phosphorylase (MTAPase), an enzyme responsible for the metabolism of 5′-deoxy-5′-methylthioadenosine (MTA), a by-product of polyamine biosyn
Autor:
Ming Y. Chu, Marvin L. Hoovis
Publikováno v:
Biochemical Pharmacology. 23:503-511
Special-conditioned medium prepared from overgrown cultures of murine leukemic cells was found to support short-term reproduction (24–96 hr) of human leukemic cells in culture. Failure of three preparations to grow in culture may be due to the inst
Autor:
Ming Y. Chu, Mu-Ill Lim, Gerald W. Crabtree, Linda B. Zuckerman, Arthur E. Bogden, Seiji Sato, Robert S. Klein
Publikováno v:
Biochemical Pharmacology. 33:1229-1234
Deazaadenosine (9-DAA), a novel purine analog, was found to be a potent inhibitor of the growth of nine different human solid tumor cell lines in vitro and of pancreatic carcinoma (DAN) in antithymocyte serum (ATS)-immunosuppressed mice. In culture,
Autor:
L.M. Tibbetts, Joseph M. Steim, S.P. Srivastava, P. Calabresi, Joseph G. Turcotte, Ming Y. Chu
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Lipids and Lipid Metabolism. 619:619-631
Among events limiting the effectiveness of cancer chemotherapy are the general lack of preferential uptake of anticancer drugs by tumor cells and the occurrence of drug resistance. An approach has been undertaken to explore whether or not such events
Autor:
Fardos N. M. Naguib, Mahmoud H. el Kouni, Zhi Hao Chen, Edward Chu, Zum Yao Weng, Ming Y. Chu, Sungman Cha, Elizabeth C. Rowe, Shih Hsi Chu
Publikováno v:
Nucleosides and Nucleotides. 7:91-102
Furanosyl analogs of BAU (5-benzylacyclouridine) and BBAU (5-benzyloxybenzylacyclouridine), two potent inhibitors of uridine phosphorylase, were synthesized and evaluated as potential cancer chemotherapeutic agents. The analogs included ribosides, 2,
Autor:
Fardos N. M. Naguib, Hahmoud H. el Kouni, Ming Y. Chu, Shih Hsi Chu, Elizabeth C. Rowe, Zhi Hao Chen
Publikováno v:
Nucleosides and Nucleotides. 3:303-311
Hydroxymethyl analogs of 5-benzylacyclouridine (BAU) and 5-benzyloxybenzylacyclouridine (BBAU) were synthesized by the condensation of appropriately blocked 2-(chloromethyl)glycerols with substituted 2, 4-dimethoxypyrimidines. The HM derivatives were
Publikováno v:
Cancer. 40:2651-2659
An in vivo model is described for assessing the antitumor activity of chemotherapeutic agents. Tumors derived from human colon carcinoma cell lines injected into antithymocyte serum (ATS) immunosuppressed mice were used. In this system, both antitumo
Publikováno v:
Biochemical Pharmacology. 8:324-326
Publikováno v:
Biochemical pharmacology. 25(3)
Publikováno v:
Chemico-biological interactions. 33(2-3)
2,2'-Anhydro-1-(3'-O-acetyl-beta-D-arabinofuranosyl)-5-iodocytosine (anhydro-araIC 3'-acetate), previously synthesized and isolated as a crude product by Moffatt and his coworkers, was purified and characterized. The availability of pure anhydro-araI