Zobrazeno 1 - 10
of 655
pro vyhledávání: '"Ming Wei Wang"'
Publikováno v:
IEEE Access, Vol 12, Pp 106480-106487 (2024)
3D lane detection from the input monocular image is a basic but indispensable task in the environment perception of automatic driving. Recent work uses modules such as depth estimation, coordinate system transformation, and time series tracking to ac
Externí odkaz:
https://doaj.org/article/f456c06702f84b539ced6eb337ece6c5
Autor:
Wenbo Feng, Qingtong Zhou, Xianyue Chen, Antao Dai, Xiaoqing Cai, Xiao Liu, Fenghui Zhao, Yan Chen, Chenyu Ye, Yingna Xu, Zhaotong Cong, Hao Li, Shi Lin, Dehua Yang, Ming-Wei Wang
Publikováno v:
Cell Discovery, Vol 9, Iss 1, Pp 1-15 (2023)
Abstract Members of the melanocortin receptor (MCR) family that recognize different melanocortin peptides mediate a broad spectrum of cellular processes including energy homeostasis, inflammation and skin pigmentation through five MCR subtypes (MC1R
Externí odkaz:
https://doaj.org/article/190a738404d84ae2b0a114c2e0d96b21
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 13, Iss 5, Pp 2291-2293 (2023)
Externí odkaz:
https://doaj.org/article/d1a1e3b8111b4025b0a5a95d22f138be
Autor:
Yan Chen, Qingtong Zhou, Jiang Wang, Youwei Xu, Yun Wang, Jiahui Yan, Yibing Wang, Qi Zhu, Fenghui Zhao, Chenghao Li, Chuan-Wei Chen, Xiaoqing Cai, Ross A .D. Bathgate, Chun Shen, H. Eric Xu, Dehua Yang, Hong Liu, Ming-Wei Wang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-15 (2023)
Relaxin family peptide receptor 4 (RXFP4) regulates pleiotropic biological processes. Here, authors report cryo-EM structures revealing the ligand-binding modes and key determinants of peptidomimetic agonism and subtype selectivity
Externí odkaz:
https://doaj.org/article/f964b0fe766549098887ae712849b234
Autor:
Han-Yi Fu, Ming-Wei Wang
Publikováno v:
Frontiers in Plant Science, Vol 14 (2023)
IntroductionAcidothermophilic cyanidiophytes in natural habitats can survive under a wide variety of light regimes, and the exploration and elucidation of their long-term photoacclimation mechanisms promises great potential for further biotechnologic
Externí odkaz:
https://doaj.org/article/a177f9c50ebd47f1b615374d9128dfaa
Publikováno v:
Frontiers in Microbiology, Vol 14 (2023)
BackgroundMinimal hepatic encephalopathy (MHE) is an early stage in the pathogenesis of hepatic encephalopathy. Intestinal microbiota is involved in the pathogenesis of hepatic encephalopathy and has become an important therapeutic target. Since ther
Externí odkaz:
https://doaj.org/article/f1778d6b8a024931947c8d2ac3f4841d
A distinctive ligand recognition mechanism by the human vasoactive intestinal polypeptide receptor 2
Autor:
Yingna Xu, Wenbo Feng, Qingtong Zhou, Anyi Liang, Jie Li, Antao Dai, Fenghui Zhao, Jiahui Yan, Chuan-Wei Chen, Hao Li, Li-Hua Zhao, Tian Xia, Yi Jiang, H. Eric Xu, Dehua Yang, Ming-Wei Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-10 (2022)
Vasoactive intestinal polypeptide receptor 2 (VIP2R) is involved in immunity. Here, the authors report two cryo-EM structures of the VIP2R–Gs in complex with the endogenous peptide ligand PACAP27, revealing a unique interaction mode between PACAP27
Externí odkaz:
https://doaj.org/article/6b052b3574ad402e83e39dc0f3c97931
Publikováno v:
Acta Pharmaceutica Sinica B, Vol 12, Iss 2, Pp 637-650 (2022)
Receptor activity-modulating proteins (RAMPs) are accessory molecules that form complexes with specific G protein-coupled receptors (GPCRs) and modulate their functions. It is established that RAMP interacts with the glucagon receptor family of GPCRs
Externí odkaz:
https://doaj.org/article/a38970a9994b4770965db4f4ffd2e872
Autor:
Fenghui Zhao, Qingtong Zhou, Zhaotong Cong, Kaini Hang, Xinyu Zou, Chao Zhang, Yan Chen, Antao Dai, Anyi Liang, Qianqian Ming, Mu Wang, Li-Nan Chen, Peiyu Xu, Rulve Chang, Wenbo Feng, Tian Xia, Yan Zhang, Beili Wu, Dehua Yang, Lihua Zhao, H. Eric Xu, Ming-Wei Wang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
Multi-targeting agonists at GIPR, GLP-1R or GCGR are pursued vigorously. Here, the authors report cryo-EM structures of tirzepatide-bound GIPR and GLP-1R, peptide 20-bound GIPR, GLP-1R and GCGR, revealing the molecular basis of their multiplexed phar
Externí odkaz:
https://doaj.org/article/641f94f40fa443e4a6c8bf6fd15fb04c
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-12 (2021)
Abstract While achieving rapid developments in recent years, bispecific antibodies are still difficult to design and manufacture, due to mispair of both heavy and light chains. Here we report a novel technology to make bispecific molecules. The knob-
Externí odkaz:
https://doaj.org/article/4c2d7b2d5b9d4fd3a54801a855b5b91f