Zobrazeno 1 - 10
of 341
pro vyhledávání: '"Ming Wah Wong"'
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-13 (2024)
Abstract The construction of N–N axially chiral motifs is an important research topic, owing to their wide occurrence in natural products, pharmaceuticals and chiral ligands. One efficient method is the atroposelective dihydropyrimidin-4-one format
Externí odkaz:
https://doaj.org/article/cc54fadd8d13465093078b596b06c076
Autor:
Yujing Zhou, Ming Wah Wong
Publikováno v:
Pharmaceuticals, Vol 17, Iss 1, p 60 (2023)
Protein tyrosine kinase 6 (PTK6), also known as breast tumor kinase (BRK), serves as a non-receptor intracellular tyrosine kinase within the Src kinases family. Structurally resembling other Src kinases, PTK6 possesses an Src homology 3 (SH3) domain,
Externí odkaz:
https://doaj.org/article/a45d385e70ef43a5a1dda1140701a8ed
Autor:
Yujing Zhou, Ming Wah Wong
Publikováno v:
Molecules, Vol 27, Iss 3, p 706 (2022)
Haspin, an atypical serine/threonine protein kinase, is a potential target for cancer therapy. 5-iodotubercidin (5-iTU), an adenosine derivative, has been identified as a potent Haspin inhibitor in vitro. In this paper, quantum chemical calculations
Externí odkaz:
https://doaj.org/article/bff2b84acd464a18a632872633ff9218
Autor:
Petar Žuvela, J. Jay Liu, Myunggi Yi, Paweł P. Pomastowski, Gulyaim Sagandykova, Mariusz Belka, Jonathan David, Tomasz Bączek, Krzysztof Szafrański, Beata Żołnowska, Jarosław Sławiński, Claudiu T. Supuran, Ming Wah Wong, Bogusław Buszewski
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1430-1443 (2018)
In this work, a target-based drug screening method is proposed exploiting the synergy effect of ligand-based and structure-based computer-assisted drug design. The new method provides great flexibility in drug design and drug candidates with consider
Externí odkaz:
https://doaj.org/article/10af111bcd05473b8f60c43ce8cbd7a1
Autor:
Krzesimir Ciura, Joanna Fedorowicz, Petar Žuvela, Mario Lovrić, Hanna Kapica, Paweł Baranowski, Wiesław Sawicki, Ming Wah Wong, Jarosław Sączewski
Publikováno v:
Molecules, Vol 25, Iss 20, p 4835 (2020)
Currently, rapid evaluation of the physicochemical parameters of drug candidates, such as lipophilicity, is in high demand owing to it enabling the approximation of the processes of absorption, distribution, metabolism, and elimination. Although the
Externí odkaz:
https://doaj.org/article/fe9601ce57504dbb9e82b9008fde9bc9
Publikováno v:
Molecules, Vol 25, Iss 13, p 3085 (2020)
Prediction of the retention time from the molecular structure using quantitative structure-retention relationships is a powerful tool for the development of methods in reversed-phase HPLC. However, its fundamental limitation lies in the fact that low
Externí odkaz:
https://doaj.org/article/e4d269be10fc4d83844f8d5bfdfed727
Autor:
Bogusław Buszewski, Petar Žuvela, Gulyaim Sagandykova, Justyna Walczak-Skierska, Paweł Pomastowski, Jonathan David, Ming Wah Wong
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 6, p 2053 (2020)
This work aimed to unravel the retention mechanisms of 30 structurally different flavonoids separated on three chromatographic columns: conventional Kinetex C18 (K-C18), Kinetex F5 (K-F5), and IAM.PC.DD2. Interactions between analytes and chromatogra
Externí odkaz:
https://doaj.org/article/f62d232222cd4a04856c3b14d49e340c
Autor:
Hui Yang, Ming Wah Wong
Publikováno v:
Molecules, Vol 25, Iss 5, p 1045 (2020)
The strong, specific, and directional halogen bond (XB) is an ideal supramolecular synthon in crystal engineering, as well as rational catalyst and drug design. These attributes attracted strong growing interest in halogen bonding in the past decade
Externí odkaz:
https://doaj.org/article/4a4ffcacb705402c8a7fa671d8c3217d
Autor:
Bokun Cho, Ming Wah Wong
Publikováno v:
Molecules, Vol 20, Iss 8, Pp 15108-15121 (2015)
DFT calculations have demonstrated that the unconventional bifunctional Brønsted-Lewis acid activation mode is generally applicable to a range of nucleophilic conjugate additions catalyzed by bicyclic guanidine catalysts. It competes readily with th
Externí odkaz:
https://doaj.org/article/9d8aa496904347b0acfcacf3a89553ad
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 14, p 3443 (2019)
In this work, we employed a non-linear programming (NLP) approach via quantitative structure−retention relationships (QSRRs) modelling for prediction of elution order in reversed phase-liquid chromatography. With our rapid and efficient approach, e
Externí odkaz:
https://doaj.org/article/c80c1adda0d640bf9271cd306c3d8474