Zobrazeno 1 - 10
of 130
pro vyhledávání: '"Ming Ta (Michael) Lee"'
Autor:
Sonia Moreno-Grau, Manvi Vernekar, Arturo Lopez-Pineda, Daniel Mas-Montserrat, Míriam Barrabés, Consuelo D. Quinto-Cortés, Babak Moatamed, Ming Ta Michael Lee, Zhenning Yu, Kensuke Numakura, Yuta Matsuda, Jeffrey D. Wall, Alexander G. Ioannidis, Nicholas Katsanis, Tomohiro Takano, Carlos D. Bustamante
Publikováno v:
Human Genomics, Vol 18, Iss 1, Pp 1-12 (2024)
Abstract Background Polygenic risk scores (PRS) derived from European individuals have reduced portability across global populations, limiting their clinical implementation at worldwide scale. Here, we investigate the performance of a wide range of P
Externí odkaz:
https://doaj.org/article/35867bdc28c94826baeb727a7d8ffbc0
Autor:
Arturo Lopez-Pineda, Manvi Vernekar, Sonia Moreno-Grau, Agustin Rojas-Muñoz, Babak Moatamed, Ming Ta Michael Lee, Marco A. Nava-Aguilar, Gilberto Gonzalez-Arroyo, Kensuke Numakura, Yuta Matsuda, Alexander Ioannidis, Nicholas Katsanis, Tomohiro Takano, Carlos D. Bustamante
Publikováno v:
Human Genomics, Vol 16, Iss 1, Pp 1-10 (2022)
Abstract Introduction A major challenge to enabling precision health at a global scale is the bias between those who enroll in state sponsored genomic research and those suffering from chronic disease. More than 30 million people have been genotyped
Externí odkaz:
https://doaj.org/article/55f9766055034ac89a4665dcb90742f8
Autor:
Vivia Khosasih, Kai-Ming Liu, Chung-Ming Huang, Lieh-Bang Liou, Ming-Shium Hsieh, Chian-Her Lee, Chang-Youh Tsai, San-Yuan Kuo, Su-Yang Hwa, Chia-Li Yu, Chih-Hao Chang, Cheng-Jyh Lin, Song-Chou Hsieh, Chun-Ying Cheng, Wei-Ming Chen, Liang-Kuang Chen, Hui-Ping Chuang, Ying-Ting Chen, Pei-Chun Tsai, Liang-Suei Lu, Weng-Siong H’ng, Yanfei Zhang, Hsiang-Cheng Chen, Chien-Hsiun Chen, Ming Ta Michael Lee, Jer-Yuarn Wu
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 3, p 3021 (2023)
While genetic analyses have revealed ~100 risk loci associated with osteoarthritis (OA), only eight have been linked to hand OA. Besides, these studies were performed in predominantly European and Caucasian ancestries. Here, we conducted a genome-wid
Externí odkaz:
https://doaj.org/article/3d85f99abf8c4798a63ba5d2bda80aab
Autor:
Yanfei Zhang, S. Mark Poler, Jiang Li, Vida Abedi, Sarah A. Pendergrass, Marc S. Williams, Ming Ta Michael Lee
Publikováno v:
BMC Medicine, Vol 17, Iss 1, Pp 1-14 (2019)
Abstract Background The alpha-adrenergic agonist phenylephrine is often used to treat hypotension during anesthesia. In clinical situations, low blood pressure may require prompt intervention by intravenous bolus or infusion. Differences in responsiv
Externí odkaz:
https://doaj.org/article/3dc7b79a9cef436096d1b19124e5dd6f
Autor:
Jiang Li, Yanfei Zhang, Alexandria L. Jilg, Donna M. Wolk, Harshit S. Khara, Amy Kolinovsky, David D. K. Rolston, Raquel Hontecillas, Josep Bassaganya-Riera, Marc S. Williams, Vida Abedi, Ming Ta Michael Lee
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
BackgroundClostridioides difficile is a major cause of healthcare-associated and community-acquired diarrhea. Host genetic susceptibility to Clostridioides difficile infection has not been studied on a large-scale.MethodsA total of 1,160 Clostridioid
Externí odkaz:
https://doaj.org/article/7759557e633a45d4a3858d28110d609c
Autor:
Yanfei Zhang, Ming Ta Michael Lee
Publikováno v:
Frontiers in Genetics, Vol 11 (2021)
Gout is a painful inflammatory arthritis affecting more than 8 million Americans. Identifying high-risk patients in early life could potentially encourage people to adopt lifestyle changes to prevent gout. Polygenic risk score (PRS) provides an overa
Externí odkaz:
https://doaj.org/article/81ff33c0ef364df0a72b9f7a737661dd
Publikováno v:
Journal of Clinical Medicine, Vol 10, Iss 12, p 2688 (2021)
Polycystic ovary syndrome (PCOS) is a complex disorder with heterogenous phenotypes and unclear etiology. A recent phenotypic clustering study identified metabolic and reproductive subtypes of PCOS. We hypothesize that the heterogeneity of PCOS manif
Externí odkaz:
https://doaj.org/article/01119728ffbe4ac18a6afefb8098afb8
Autor:
Chia-Jung Chang, Chien-Hsiun Chen, Bing-Mae Chen, Yu-Cheng Su, Ying-Ting Chen, Michael S. Hershfield, Ming-Ta Michael Lee, Tian-Lu Cheng, Yuan-Tsong Chen, Steve R. Roffler, Jer-Yuarn Wu
Publikováno v:
Nature Communications, Vol 8, Iss 1, Pp 1-7 (2017)
Some individuals develop antibodies against the polyethylene glycol that is commonly used in therapeutic preparations. Here the authors conduct a GWAS in Han Chinese and find the IGH locus is associated with anti-PEG IgM.
Externí odkaz:
https://doaj.org/article/df2dcbdf3ece4077a9f03be585cdb8d7
Autor:
Yanfei Zhang, Waleed Zafar, Dustin N. Hartzel, Marc S. Williams, Adrienne Tin, Alex R. Chang, Ming Ta Michael Lee
Publikováno v:
Frontiers in Genetics, Vol 10 (2019)
Deletion of glutathione S-transferase µ1 (GSTM1) is common in populations and has been asserted to associate with chronic kidney disease progression in some research studies. The association needs to be validated. We estimated GSTM1 copy number usin
Externí odkaz:
https://doaj.org/article/316fd911d8a442e0a883538abb08bd0d
Autor:
Adem Y, Dawed, Sook Wah, Yee, Kaixin, Zhou, Nienke, van Leeuwen, Yanfei, Zhang, Moneeza K, Siddiqui, Amy, Etheridge, Federico, Innocenti, Fei, Xu, Josephine H, Li, Joline W, Beulens, Amber A, van der Heijden, Roderick C, Slieker, Yu-Chuan, Chang, Josep M, Mercader, Varinderpal, Kaur, John S, Witte, Ming Ta Michael, Lee, Yoichiro, Kamatani, Yukihide, Momozawa, Michiaki, Kubo, Colin N A, Palmer, Jose C, Florez, Monique M, Hedderson, Leen M, 't Hart, Kathleen M, Giacomini, Ewan R, Pearson
Publikováno v:
Diabetes care. 45(4)