Výsledky vyhledávání - "Ming Shiu Hung"

Akademický článek

Decrypting orphan GPCR drug discovery via multitask learning

Autor: Wei-Cheng Huang, Wei-Ting Lin, Ming-Shiu Hung, Jinq-Chyi Lee, Chun-Wei Tung

Publikováno v: Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-11 (2024)

Abstract The drug discovery of G protein-coupled receptors (GPCRs) superfamily using computational models is often limited by the availability of protein three-dimensional (3D) structures and chemicals with experimentally measured bioactivities. Orph

Externí odkaz: https://doaj.org/article/253a48971ddb440ca47f20d19d23b992

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Akademický článek

Orexins contribute to restraint stress-induced cocaine relapse by endocannabinoid-mediated disinhibition of dopaminergic neurons

Autor: Li-Wei Tung, Guan-Ling Lu, Yen-Hsien Lee, Lung Yu, Hsin-Jung Lee, Emma Leishman, Heather Bradshaw, Ling-Ling Hwang, Ming-Shiu Hung, Ken Mackie, Andreas Zimmer, Lih-Chu Chiou

Publikováno v: Nature Communications, Vol 7, Iss 1, Pp 1-14 (2016)

Stress is a major cause of relapse to cocaine seeking behaviour. Tung et al. show that orexin mediates stress-induced reinstatement of cocaine seeking behaviour in mice by endocannabinoid-dependent disinhibition in the ventral tegmental area.

Externí odkaz: https://doaj.org/article/6fb8a2e8693f4fcf8b5d51e6da9be8c1

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Modulating the affinity and signaling bias of cannabinoid receptor 1 antagonists

Autor: Wen-Chi Hsiao, Kun-Yi Hsin, Zhong-Wei Wu, Jen-Shin Song, Yen-Nan Yeh, Yan-Fu Chen, Chia-Hua Tsai, Pei-Hsuan Chen, Kak-Shan Shia, Chun-Ping Chang, Ming-Shiu Hung

Publikováno v: Bioorganic chemistry. 130

Cannabinoid receptor 1 (CB1) is a G protein-coupled receptor and a therapeutic target for metabolic disorders. Numerous CB1 antagonists have been developed, but their functional selectivities and bias towards G protein or β-arrestin signaling have n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11f4b7fa1fad7bb1c84b55597b6cdc6a
https://pubmed.ncbi.nlm.nih.gov/36371817

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Unique Sulfur–Aromatic Interactions Contribute to the Binding of Potent Imidazothiazole Indoleamine 2,3-Dioxygenase Inhibitors

Publikováno v: Journal of Medicinal Chemistry. 63:1642-1659

Indoleamine 2,3-dioxygenase (IDO1) inhibitors are speculated to be useful in cancer immunotherapy, but a phase III clinical trial of the most advanced IDO1 inhibitor, epacadostat, did not meet its primary end point and was abandoned. In previous work

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4258e7674e4456ad315cdaea64c49e02
https://doi.org/10.1021/acs.jmedchem.9b01549

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Discovery and development of a novel N-(3-bromophenyl)-{[(phenylcarbamoyl)amino]methyl}-N-hydroxythiophene-2-carboximidamide indoleamine 2,3-dioxygenase inhibitor using knowledge-based drug design

Publikováno v: European journal of medicinal chemistry. 229

Indoleamine 2,3-dioxygenase-1 (IDO1) is a potential target for the next generation of cancer immunotherapies. We describe the development of two series of IDO1 inhibitors incorporating a N-hydroxy-thiophene-carboximidamide core generated by knowledge

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::74c490b623ec9a953cd1fcf3690ae527
https://pubmed.ncbi.nlm.nih.gov/34929581

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Increasing endogenous PPARγ ligands improves insulin sensitivity and protects against diet-induced obesity without side effects of thiazolidinediones

Insulin resistance and obesity are pivotal features of type 2 diabetes mellitus. Peroxisome proliferator-activated receptor γ (PPARγ) is a master transcriptional regulator of systemic insulin sensitivity and energy balance. The anti-diabetic drug t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2411d76f38c514201c45ebedddb1efc6
https://doi.org/10.21203/rs.3.rs-490889/v1

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Caveolin-1 Secreted from Adipose Tissues and Adipocytes Functions as an Adipogenesis Enhancer

Autor: Chia Chu Chang, Hsi Chi Lu, Chih Yang Huang, Hui Chin Wen, Chung Ho Chang, Ming Shiu Hung, Chen Yu Chen, Woan Ling Chen

Publikováno v: Obesity. 25:1932-1940

Objective Caveolin-1 (Cav-1) is expressed abundantly in adipose tissue and involved in many physiological processes. While Cav-1 has been reported to be secreted in pancreatic acinar cells and LNCaP prostate cancer cells, its secretion from adipose t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f1718d9b34413f623f9ec49e3e6aef54
https://doi.org/10.1002/oby.21970

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A structure-function approach identifies L-PGDS as a mediator responsible for glucocorticoid-induced leptin expression in adipocytes

Autor: Kun-Yi Hsin, Yen-Nan Yeh, Lih-Yuan Lin, Ming-Shiu Hung, Andreas Zimmer

Publikováno v: Biochemical pharmacology. 166

Leptin is an adipokine predominantly secreted by adipocytes and has many physiological roles, including in energy homeostasis. We identified that AM630, a cannabinoid receptor 2 (CB2) antagonist, down-regulated leptin expression in mature adipocytes

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::952fd23526b0751128146d0beb5a4ecb
https://pubmed.ncbi.nlm.nih.gov/31129049

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