Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Ming Kei Lee"'
Autor:
Ming Kei Lee, Sama Seyedmousavi, Sylvain Auvity, Bertrand Pourroy, Vincent Elleboode, Isabelle Kachaner, Christel Jansen, Herve Lilliu
Publikováno v:
Frontiers in Medicine, Vol 11 (2024)
ObjectiveTo evaluate the potential impact of cell and gene therapies (CGTs) in France by forecasting the number of patients that will be treated with CGTs over the period 2023–2030 by therapeutic area and region.MethodsA review of CGTs in clinical
Externí odkaz:
https://doaj.org/article/bb8bd8683d894df29fa28cd445fdebd0
Autor:
Ming Kei Lee, Kanaga Sabapathy
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 9, Iss 9, Pp 690-698 (2007)
-γ-Irradiation- mediated ataxia telangiectasia mutated (ATM)-dependent dephosphorylation of serine 376 (S376) at the carboxyl terminus of human p53 results in the exposure of the 14-3-3 consensus-binding site, which includes serine 378 (S378).14-3-3
Externí odkaz:
https://doaj.org/article/d94b91afd4a74f64b07c87da4493b57b
Publikováno v:
Cancer Cell. 22:751-764
SummaryThe specific roles of mutant p53's dominant-negative (DN) or gain-of-function (GOF) properties in regulating acute response and long-term tumorigenesis is unclear. Using “knockin” mouse strains expressing varying R246S mutant levels, we sh
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c290cf107ca757224386a59d227e075
https://doi.org/10.1016/j.ccr.2012.10.022
https://doi.org/10.1016/j.ccr.2012.10.022
Autor:
Ming Kei Lee, Kanaga Sabapathy
Publikováno v:
Journal of Cell Science. 121:1899-1906
p53 is the most frequently mutated tumour-suppressor gene in human cancers. Mutant p53 is thought to contribute to carcinogenesis by the acquisition of gain-of-function properties or through the exertion of dominant-negative (DN) effects over the rem
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3ea1349a0ca5e2e69a11903fe4998088
https://doi.org/10.1242/jcs.022822
https://doi.org/10.1242/jcs.022822
Publikováno v:
Nucleic Acids Research
Tumour-derived p53 mutants are thought to have acquired 'gain-of-function' properties that contribute to oncogenicity. We have tested the hypothesis that p53 mutants suppress p53-target gene expression, leading to enhanced cellular growth. Silencing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6ebf7a155ba4eaf6eb75a6c082c27a6b
https://doi.org/10.1093/nar/gkm099
https://doi.org/10.1093/nar/gkm099
Publikováno v:
International Journal of Cancer. 119:745-749
Hepatocellular carcinoma (HCC) is a common human malignancy that is often associated with risk factors such as aflatoxin-B1 (AFB1) exposure and Hepatitis-B virus infection in developing countries. There is a strong correlation between these risk fact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2cd4b0bd6a620d39057c7722252c90c2
https://doi.org/10.1002/ijc.21890
https://doi.org/10.1002/ijc.21890
Publikováno v:
Clinical Cancer Research. 11:4348-4356
Mutations in p53 are common events during carcinogenesis and have been suggested to affect sensitivity to chemotherapy. Recently, the common polymorphism at codon 72, resulting in either an arginine (72R) or proline (72P) residue, was shown to differ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2adebcb3178bbe262b4a126a46b2d904
https://doi.org/10.1158/1078-0432.ccr-04-1547
https://doi.org/10.1158/1078-0432.ccr-04-1547
Publikováno v:
Journal of Cell Science. 118:819-829
The fundamental role of telomerase is to protect telomere ends and to maintain telomere length during replication; hence, telomerase expression is high in stem cells but reduced upon differentiation. Recent studies indicate that telomerase might play
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6dc5ee46193cf263393fb31284a0d1d1
https://doi.org/10.1242/jcs.01673
https://doi.org/10.1242/jcs.01673
Publikováno v:
The Journal of physiology. 586(2)
Immune-independent diabetes often occurs via pancreatic beta cell dysfunction. However, the role of the tumour suppressor p53 that regulates cellular life and death in multiple tissues, in pancreatic cell death and diabetes has not been clarified. We
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::04eba1155781fcc3f11e884509ba3421
https://pubmed.ncbi.nlm.nih.gov/18006584
https://pubmed.ncbi.nlm.nih.gov/18006584