Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Ming Jo Hsu"'
Autor:
Dongfang Meng, Dann L. Parker, Robin Kirwan, M A Powles, Jennifer Nielsen Kahn, James M. Apgar, Fred Racine, Paul A. Liberator, Amy M. Flattery, Andrew Galgoci, Kingsley H. Nelson, James M. Balkovec, Andrew S. Misura, Weiming Fan, Donald M. Sperbeck, Michael Robert Peel, Robert A. Giacobbe, Mark L. Greenlee, Ahmed Mamai, Jasminka Dragovic, Kenneth J. Wildonger, Hao Liu, Robert R. Wilkening, Mary Motyl, Shu Lee, Ming-Jo Hsu, Charles Gill, George K. Abruzzo
Publikováno v:
Bioorganicmedicinal chemistry letters. 32
We previously reported medicinal chemistry efforts that identified MK-5204, an orally efficacious β-1,3-glucan synthesis inhibitor derived from the natural product enfumafungin. Further extensive optimization of the C2 triazole substituent identifie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f9a5b1dc4caa4f8e8040bb53f3f65ed
https://pubmed.ncbi.nlm.nih.gov/33160023
https://pubmed.ncbi.nlm.nih.gov/33160023
Autor:
James M. Balkovec, Robert A. Giacobbe, Jennifer Nielsen Kahn, Ming Jo Hsu, Weiming Fan, Ahmed Mamai, Michael Robert Peel, James M. Apgar, Amy M. Flattery, Paul A. Liberator, Fred Racine, Bahanu Habulihaz, Mary Motyl, Kingsley H. Nelson, Robert R. Wilkening, Robin Kirwan, M A Powles, George K. Abruzzo, Andrew Galgoci, Charles Gill, Andrew S. Misura, Shu Lee, Jasminka Dragovic, Hao Liu, Mark L. Greenlee
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 25:5813-5818
The clinical success of the echinocandins, which can only be administered parentally, has validated β-1,3-glucan synthase (GS) as an antifungal target. Semi-synthetic modification of enfumafungin, a triterpene glycoside natural product, was performe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75f12625a2e82e86dbbc4c61aa3a8424
https://doi.org/10.1016/j.bmcl.2015.10.011
https://doi.org/10.1016/j.bmcl.2015.10.011
Autor:
Dann L. Parker, James M. Apgar, Robert A. Giacobbe, Ming Jo Hsu, Kingsley H. Nelson, Gregory J. Pacofsky, Paul A. Liberator, Fred Racine, Dongfang Meng, Ghjuvanni Coti, James M. Balkovec, Ahmed Mamai, Brian H. Heasley, Mark L. Greenlee, Jennifer Nielsen Kahn, Michael Robert Peel, Robert R. Wilkening, Hao Liu
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:6811-6816
Orally bioavailable inhibitors of β-(1,3)- d -glucan synthase have been pursued as new, broad-spectrum fungicidal therapies suitable for treatment in immunocompromised patients. Toward this end, a collaborative medicinal chemistry program was establ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9e0eb37f90354231988b66512b32d5ce
https://doi.org/10.1016/j.bmcl.2012.05.031
https://doi.org/10.1016/j.bmcl.2012.05.031
Autor:
Ming-Jo Hsu, Kathleen Calati, Guy H. Harris, Craig A. Parish, Terry Roemer, Javier Collado, Jennifer Nielsen Kahn, Jesús Martín, David P. Overy
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 19:1224-1227
Parnafungins, natural products containing an isoxazolidinone ring, have been isolated from Fusarium larvarum and have been shown to be potent inhibitors of the fungal polyadenosine polymerase. The extraction and analysis of fermentation broths of tax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d323339972c817ab2cd9231ddbaf2852
https://doi.org/10.1016/j.bmcl.2008.12.081
https://doi.org/10.1016/j.bmcl.2008.12.081
Autor:
Michael C. Justice, Karen Carniol, Jennifer Nielsen, Dennis M. Schmatz, Theresa Ku, Ming-Jo Hsu
Publikováno v:
Journal of Biological Chemistry. 274:4869-4875
The natural product sordarin, a tetracyclic diterpene glycoside, selectively inhibits fungal protein synthesis by impairing the function of eukaryotic elongation factor 2 (eEF2). Sordarin and its derivatives bind to the eEF2-ribosome-nucleotide compl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903798fb3786bc18de2080c3a1b7d5a5
https://doi.org/10.1074/jbc.274.8.4869
https://doi.org/10.1074/jbc.274.8.4869
Autor:
Guillermo Garcia-Effron, Ming Jo Hsu, Steven Park, Kieren A. Marr, David S. Perlin, Jennifer Nielsen Kahn
Publikováno v:
Antimicrobial Agents and Chemotherapy. 51:1876-1878
A Candida krusei strain from a patient with acute myelogenous leukemia that displayed reduced susceptibility to echinocandin drugs contained a heterozygous mutation, T2080K, in FKS1 . The resulting Phe655→Cys substitution altered the sensitivity of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4070f38382f7efbec5f12f7b8c63974
https://doi.org/10.1128/aac.00067-07
https://doi.org/10.1128/aac.00067-07
Autor:
Theresa Ku, Jennifer Nielsen, Michael C. Justice, Ming-Jo Hsu, Dennis M. Schmatz, James M. Balkovec, Bruno Tse
Publikováno v:
Journal of Biological Chemistry. 273:3148-3151
Elongation factor 2 (EF2) is an essential protein catalyzing ribosomal translocation during protein synthesis and is highly conserved in all eukaryotes. It is largely interchangeable in translation systems reconstituted from such divergent organisms
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8aebf95a78658fedb94d6e58d1a7f3c5
https://doi.org/10.1074/jbc.273.6.3148
https://doi.org/10.1074/jbc.273.6.3148
Publikováno v:
Journal of Bacteriology. 178:4381-4391
Saccharomyces cerevisiae has two highly homologous genes, FKS1 and FKS2, which encode interchangeable putative catalytic subunits of 1,3-beta-glucan synthase (GS), an enzyme that synthesizes an essential polymer of the fungal cell wall. To determine
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8c60e26bbf71761c620632ab6d1a9798
https://doi.org/10.1128/jb.178.15.4381-4391.1996
https://doi.org/10.1128/jb.178.15.4381-4391.1996
Autor:
Guy H. Harris, Terry Roemer, Jesús Martín, Jennifer Nielsen Kahn, Ming-Jo Hsu, Craig A. Parish, Kathleen Calati, David P. Overy, Javier Collado
Publikováno v:
ChemInform. 40
Parnafungins, natural products containing an isoxazolidinone ring, have been isolated from Fusarium larvarum and have been shown to be potent inhibitors of the fungal polyadenosine polymerase. The extraction and analysis of fermentation broths of tax
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::65d5c157a32e2ebf002f8cc2e8ed8943
https://doi.org/10.1002/chin.200928199
https://doi.org/10.1002/chin.200928199
Publikováno v:
Biochimica et Biophysica Acta (BBA) - General Subjects. 1115:131-140
Although previous studies have shown that serum albumin binds PGI2 and protects it from rapid degradation, it remains debatable whether it is physiologically important due to its low binding affinity for PGI2. We were intrigued by the observations of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::471453bc6ff64958c409b503391bc3ba
https://doi.org/10.1016/0304-4165(91)90021-8
https://doi.org/10.1016/0304-4165(91)90021-8