Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Ming Fai Chan"'
Autor:
Shashidhar N. Rao, Kalyanaraman Ramnarayan, Vitukudi Narayanaiyengar Balaji, Salvatore Profeta, Ming Fai Chan
Publikováno v:
International Journal of Peptide and Protein Research. 45:366-376
As a part of the development of conformational guidelines for the design of metabolically altered peptidomimetics, we present conformational energy calculations on model dipeptide compounds with glycine (Gly), L-alanine (Ala), alpha-aminoisobutyric a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6e7aa86012e81d9e24298363eca56e63
https://doi.org/10.1111/j.1399-3011.1995.tb01050.x
https://doi.org/10.1111/j.1399-3011.1995.tb01050.x
Autor:
Achim H.-P. Krauss, Charles E. Protzman, Licheng Shi, R. M. Burk, R. Chen, Steven W. Andrews, George Sachs, H. T. T. Dinh, Heather A. Krauss, Karen M. Kedzie, A.M. Bogardus, L. J. Kaplan, Michael B. Roof, M. E. Garst, Ming Fai Chan, Larry A. Wheeler, R. A. Ross, John W. Regan, Todd S. Gac, June Chen, Kristen L. Pierce, D.F. Woodward, D. W. Gil
Publikováno v:
British Journal of Pharmacology. 130:1933-1943
Replacement of the carboxylic acid group of PGF(2alpha) with the non-acidic substituents hydroxyl (-OH) or methoxy (-OCH(3)) resulted in an unexpected activity profile. Although PGF(2alpha) 1-OH and PGF(2alpha) 1-OCH(3) exhibited potent contractile e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4db77a4e459e159e2b98cf72dd45616b
https://doi.org/10.1038/sj.bjp.0703462
https://doi.org/10.1038/sj.bjp.0703462
Autor:
Ilya Okun, Raju Bore Gowda, Chengde Wu, Fiona Stavros, Ming Fai Chan, Rosario Silvestre Castillo
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:2093-2098
A series of 2-aryloxycarbonylthiophene-3-sulfonamides were synthesized and evaluated to determine their antagonistic activity at the endothelin receptors. N-(4-chloro-3-methyl-5-isoxazolyl)-2-[(3,4-methylenedioxy)phenoxycarbonyl]thiophene-3-sulfonami
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::551a6fe952672695f6b4fb5a555ccf8c
https://doi.org/10.1016/s0960-894x(97)00367-3
https://doi.org/10.1016/s0960-894x(97)00367-3
Publikováno v:
Bulletin of the Chemical Society of Japan. 70:293-299
Peptides with conformationally restricted 1-aminocyclopropane-1-carboxylic acid (Acc3) moieties were previously shown to exhibit preference for γ-turn structures in the solution phase and solid phase. We present conformational energy calculations on
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c14adc84feca720952112091ee4e20a
https://doi.org/10.1246/bcsj.70.293
https://doi.org/10.1246/bcsj.70.293
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:939-944
The potential proteolytic instability of the amide bond present in some ET A selective thiophenesulfonamide endothelin antagonists exemplified by TBC-10708 led us to investigate the replacement of this moiety with stable amide bond surrogates such as
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d342adda8e4ef452e5a403a7f7edf81a
https://doi.org/10.1016/s0960-894x(97)00133-9
https://doi.org/10.1016/s0960-894x(97)00133-9
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 7:933-938
The aryloxymethylene group was used as a replacement for an ester or amide bond present in a series of ETA selective endothelin antagonists. The effect of such replacement on the binding affinity is described.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::6ae17ebbd6629e77c45f0772e3634b8e
https://doi.org/10.1016/s0960-894x(97)00132-7
https://doi.org/10.1016/s0960-894x(97)00132-7
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2651-2656
The synthesis and in vitro binding affinities of a series of thiophenesulfonamides as ETA selective endothelin receptor antagonists is described. The most potent inhibitor displayed an IC50 of 43 nM and 3 μM to ETA and ETB receptors, respectively.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d1396ca14706db2068f5944c3ab4a338
https://doi.org/10.1016/s0960-894x(96)00496-9
https://doi.org/10.1016/s0960-894x(96)00496-9
Autor:
Ilya Okun, Ming Fai Chan, Rosario Silvestre Castillo, Fiona Stavros, Raju Bore Gowda, Emily Hwang, Balaji Vitukudi Narayanaiyenga, Adam Kois, Chengde Wu, Erik Verner
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 6:2393-2398
Replacement of the 4-methyl group in a series of N-(3,4-dimethylisoxazolyl)benzenesulfonamide endothelin antagonists with a bromine or chlorine atom resulted in a three- to ten-fold increase in the binding affinity for both the ETA and ETB receptors.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4f5becdfc4f23bbb9e55cc361edb527c
https://doi.org/10.1016/0960-894x(96)00441-6
https://doi.org/10.1016/0960-894x(96)00441-6
Publikováno v:
Protein & Peptide Letters. 3:31-38
Abstract: We present conformational energy calculations on model compounds contammg 1-amino cycloalkane carboxylic acid with 5- (Acc5 )and 6- (Acc6) membered rings using molecular mechanics methods. The low energy models adopt conformations charact
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::64620abff1176ffe88fd9ba4999c7524
https://doi.org/10.2174/092986650301220608154039
https://doi.org/10.2174/092986650301220608154039
Publikováno v:
Journal of Structural Biology. 115:267-274
We present conformation energy calculations on the model dipeptide 1-acetylamino- N -methyl-2,5-cyclohexadiene-1-carboxamide (1) and its two derivatives in which the C-2 and C-6 of the cyclohexadiene ring are substituted. The energy calculations have
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::385211abbafd1a3fe77b5c480224ecd4
https://doi.org/10.1006/jsbi.1995.1051
https://doi.org/10.1006/jsbi.1995.1051