Zobrazeno 1 - 10
of 40
pro vyhledávání: '"Ming Chieh Shun"'
Autor:
Junpeng Yan, Ming-Chieh Shun, Caili Hao, Yi Zhang, Juan Qian, Kasia Hrecka, Maria DeLucia, Christina Monnie, Jinwoo Ahn, Jacek Skowronski
Publikováno v:
mBio, Vol 9, Iss 5 (2018)
ABSTRACT Viral accessory proteins hijack host cell E3 ubiquitin ligases to antagonize innate/intrinsic defenses and thereby provide a more permissive environment for virus replication. Human immunodeficiency virus type 1 (HIV-1) accessory protein Vpr
Externí odkaz:
https://doaj.org/article/56ce2447f8324b7eadd44ac5a495e2e4
Publikováno v:
PLoS ONE, Vol 10, Iss 9, p e0137797 (2015)
Hepatoma-derived growth factor (HDGF) related protein 2 (HRP2) and lens epithelium-derived growth factor (LEDGF)/p75 are closely related members of the HRP2 protein family. LEDGF/p75 has been implicated in numerous human pathologies including cancer,
Externí odkaz:
https://doaj.org/article/0711bc4b6e1842b4bb05b59c66511675
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance An obligatory step in the replication cycle of all retroviruses involves reverse transcription of their RNA genomes into double-stranded DNA for integration into the host cell chromosome. The process of synthesizing double-stranded HIV-1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6b5c56d5de6fd7b79ca677b36c181bce
http://europepmc.org/articles/PMC6511057
http://europepmc.org/articles/PMC6511057
Autor:
Hao Wang, Ming-Chieh Shun, Xiang Li, Francesca Di Nunzio, Stephen Hare, Peter Cherepanov, Alan Engelman
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 1, Iss C (2014)
Controlling the specificity of retroviral DNA integration could improve the safety of gene therapy vectors, and fusions of heterologous chromatin binding modules to the integrase (IN)–binding domain from the lentiviral integration host cofactor len
Externí odkaz:
https://doaj.org/article/441e4ec4fb3747a0b6bbd81d1d11f540
Autor:
Stephen Hare, Ming-Chieh Shun, Saumya Shree Gupta, Eugene Valkov, Alan Engelman, Peter Cherepanov
Publikováno v:
PLoS Pathogens, Vol 5, Iss 1, p e1000259 (2009)
Lens epithelium derived growth factor (LEDGF), also known as PC4 and SFRS1 interacting protein 1 (PSIP1) and transcriptional co-activator p75, is the cellular binding partner of lentiviral integrase (IN) proteins. LEDGF accounts for the characteristi
Externí odkaz:
https://doaj.org/article/f37278f763ce45e297e405e097d7fdef
Autor:
Ming-Chieh Shun1, Weiping Yu2, Sook-Kyung Park2, Sanders, Bob G.2, Kline, Kimberly3 k.kline@mail.utexas.edu
Publikováno v:
Journal of Oncology. 2010, p1-11. 11p. 6 Black and White Photographs, 1 Diagram, 2 Graphs.
Autor:
Hare, Stephen1, Ming-Chieh Shun2, Gupta, Saumya Shree1, Valkov, Eugene1, Engelman, Alan2 alanengelman@dfci.harvard.edu, Cherepanov, Peter1 p.cherepanov@imperial.ac.u
Publikováno v:
PLoS Pathogens. Jan2009, Vol. 5 Issue 1, p1-12. 12p. 3 Diagrams, 1 Chart, 2 Graphs.
Autor:
Ming-Chieh Shun1, Weiping Yu2, Gapor, Abdul3, Parsons, Rachel4, Atkinson, Jeffrey4, Sanders, Bob G.2, Kline, Kimberly1
Publikováno v:
Nutrition & Cancer. 2004, Vol. 48 Issue 1, p95-105. 11p.
Autor:
Claudia Stewart, Andrea L. Ferris, Alan Engelman, Thomas A. Milne, Gang Greg Wang, Ming Chieh Shun, Christina M. Hughes, Steven J. Smith, C. David Allis, Stephen H. Hughes, Xiaolin Wu
Lens epithelium-derived growth factor (LEDGF) fusion proteins can direct HIV-1 DNA integration to novel sites in the host genome. The C terminus of LEDGF contains an integrase binding domain (IBD), and the N terminus binds chromatin. LEDGF normally d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99dda50844f48795eb8d67799cfa4ac2
https://doi.org/10.1073/pnas.0914142107
https://doi.org/10.1073/pnas.0914142107
Autor:
Sarabpreet Kaur, Laurence Florens, Jacek Skowronski, Michael P. Washburn, Caili Hao, Ming Chieh Shun, Kasia Hrecka, Selene K. Swanson
HIV replication in nondividing host cells occurs in the presence of high concentrations of noncanonical dUTP, apolipoprotein B mRNA-editing, enzyme-catalytic, polypeptide-like 3 (APOBEC3) cytidine deaminases, and SAMHD1 (a cell cycle-regulated dNTP t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc5309a46f7a940c622f28241cf3c2ee
https://europepmc.org/articles/PMC4941427/
https://europepmc.org/articles/PMC4941427/