Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Ming Chen Chou"'
Autor:
Yi-Fan Chen, Chien-Huang Wu, Li-Hsien Chen, Hao-Wei Lee, Jinq-Chyi Lee, Teng-Kuang Yeh, Jang-Yang Chang, Ming-Chen Chou, Hui-Ling Wu, Yen-Po Lai, Jen-Shin Song, Kai-Chia Yeh, Chiung-Tong Chen, Chia-Jui Lee, Kak-Shan Shia, Meng-Ru Shen
Publikováno v:
Journal of Medicinal Chemistry. 65:4767-4782
Chemotherapy-induced neurotoxicity is a common adverse effect of cancer treatment. No medication has been shown to be effective in the prevention or treatment of chemotherapy-induced neurotoxicity. Using minoxidil as an initial template for structura
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c9de05213df23537b3f1c8dc161eb5db
https://doi.org/10.1021/acs.jmedchem.1c01912
https://doi.org/10.1021/acs.jmedchem.1c01912
Autor:
Kai-Chia Yeh, Chia-Jui Lee, Jen-Shin Song, Chien-Huang Wu, Teng-Kuang Yeh, Szu-Huei Wu, Tsung-Chin Hsieh, Yen-Ting Chen, Huan-Yi Tseng, Chen-Lung Huang, Chiung-Tong Chen, Jiing-Jyh Jan, Ming-Chen Chou, Kak-Shan Shia, Kuang-Hsing Chiang
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 19; Pages: 11730
CXCR4 antagonists have been claimed to reduce mortality after myocardial infarction in myocardial infarction (MI) animals, presumably due to suppressing inflammatory responses caused by myocardial ischemia-reperfusion injury, thus, subsequently facil
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::14c4e017bb2221055542384ec9de728f
https://doi.org/10.3390/ijms231911730
https://doi.org/10.3390/ijms231911730
Autor:
Yi-Yu Ke, Ming-Chen Chou, Jiing-Jyh Jan, Trinh Kieu Dinh, Chien-Huang Wu, Chia-Jui Lee, Kai-Chia Yeh, Jing-Kai Huang, Yen-Nhi Ngoc Ta, Kuan-Wei Huang, Kak-Shan Shia, Jen-Shin Song, Yun-Chieh Sung, Chih-Chun Chang, Teng-Kuang Yeh, Ting-Yun Shiue, Yunching Chen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance A highly selective, safe, and potent CXCR4 antagonist, BPRCX807, has been designed and experimentally validated in various hepatocellular carcinoma models. Through combination therapy, it can synergize with either a kinase (e.g., sorafen
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fb5b594bec713b18d964bcc9a233a691
https://pubmed.ncbi.nlm.nih.gov/33753481
https://pubmed.ncbi.nlm.nih.gov/33753481
Autor:
Ming-Chen Chou, 周明蓁
107
In this study, in order to fulfill the uniform and large area growth of molybdenum sulfide film (MoS2), zinc sulfide (ZnS) film was pre-grown as a buffer layer on c-oriented sapphire substrate by atomic layer deposition (ALD), both of the tw
In this study, in order to fulfill the uniform and large area growth of molybdenum sulfide film (MoS2), zinc sulfide (ZnS) film was pre-grown as a buffer layer on c-oriented sapphire substrate by atomic layer deposition (ALD), both of the tw
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/e9v5w7
Autor:
Yi-Yu Ke, Jiing-Jyh Jan, Chen-Tso Tseng, Chen-Lung Huang, Kai-Chia Yeh, Ming-Chen Chou, Chiung-Tong Chen, Szu-Huei Wu, Chia-Jui Lee, Sing-Yi Wang, Lun K. Tsou, Jen-Shin Song, Kak-Shan Shia, Chien-Huang Wu, Po-Chu Kuo, Teng-Kuang Yeh, Hsuan‐Hao Kuan, Mine-Hsine Wu
Publikováno v:
Journal of medicinal chemistry. 61(3)
The function of the CXCR4/CXCL12 axis accounts for many disease indications, including tissue/nerve regeneration, cancer metastasis, and inflammation. Blocking CXCR4 signaling with its antagonists may lead to moving out CXCR4+ cell types from bone ma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673e4a8498bb2f6a8a1ac4e555d7c1e3
https://pubmed.ncbi.nlm.nih.gov/29314840
https://pubmed.ncbi.nlm.nih.gov/29314840
Autor:
Chuan Jen Wang, Amit A. Sadani, Hsin Pang Hsieh, Elizabeth A. Gullen, Yung-Chi Cheng, Chia-Yi Cheng, Yun Chen Tien, Jing Ma, Ming Chen Chou, Chun-Ping Chang, Yi Yu Ke, Chen Fu Lo, Lun K. Tsou, Tsung Chih Hsieh, Jiing Jyh Jan, Jen Shin Song, Yu Wei Liu, Ying Chieh Wong, Chia Hua Tsai, Chien Huang Wu, Kak Shan Shia
Publikováno v:
Journal of Medicinal Chemistry. 58:1452-1465
Motivated by the pivotal role of CXCR4 as an HIV entry co-receptor, we herein report a de novo hit-to-lead effort on the identification of subnanomolar purine-based CXCR4 antagonists against HIV-1 infection. Compound 24, with an EC50 of 0.5 nM agains
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa19206a3e5b5af84e76abcf8c074d1b
https://doi.org/10.1021/jm501772w
https://doi.org/10.1021/jm501772w
Autor:
Jen-Shin Song, Chih-Chun Chang, Chien-Huang Wu, Trinh Kieu Dinh, Jiing-Jyh Jan, Kuan-Wei Huang, Ming-Chen Chou, Ting-Yun Shiue, Kai-Chia Yeh, Yi-Yu Ke, Teng-Kuang Yeh, Yen-Nhi Ngoc Ta, Chia-Jui Lee, Jing-Kai Huang, Yun-Chieh Sung, Kak-Shan Shia, Yunching Chen
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 3/30/2021, Vol. 118 Issue 13, p1-11, 11p
Publikováno v:
Advanced Synthesis & Catalysis. 356:3025-3038
A convenient and general approach for cyclopenta[b]naphthalene derivatives containing a structurally diverse functionality at C-4 position has been successfully developed, whereby manganese(III) acetate plays a key role to facilitate the tandem 5-exo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5bd5909517f7dd8520dcb28624cd9088
https://doi.org/10.1002/adsc.201400257
https://doi.org/10.1002/adsc.201400257
Autor:
Ming-Shiu Hung, Kak-Shan Shia, Ming-Chen Chou, Kun-Hung Chen, Po-Chu Kuo, Chen-Tso Tseng, Ying-Chieh Wong, Pei-Hsuan Chen, Shi-Liang Tseng, Teng-Kuang Yeh, Ming-Hung Ou, Jen-Shin Song, Kuei-Hua Chang, Yu-Sheng Chao, Chien-Huang Wu, Yinchiu Lin, Amit A. Sadani, Chun-Ping Chang
Publikováno v:
Journal of Medicinal Chemistry. 56:9920-9933
After extensive synthetic efforts, we found that many structurally diverse bioisosteres could be generated via derivatizing the C-4 alkyl chain on the pyrazole ring of compound 3 (B/P = 1/33) with different electronegative groups. Especially when a s
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::18ac61baf7245c5fa3bed4f850d15eaf
https://doi.org/10.1021/jm401158e
https://doi.org/10.1021/jm401158e
Autor:
Chien-Huang Wu, Ming-Shiu Hung, Chin-Yu Lin, Min-Tsang Hsieh, Jiing-Jyh Jan, Cheng-Ming Chu, Kak-Shan Shia, Ming-Chen Chou, Teng-Kuang Yeh, Horng-Shing Shy, Jen-Shin Song, Yu-Sheng Chao, Shi-Liang Tseng, Yen-Nan Yeh, Wan-Ping Hsieh, Yinchiu Lin, Chun-Wei Kuo, Wan-Ling Chung, Chun-Ping Chang
Publikováno v:
Journal of Medicinal Chemistry. 52:4496-4510
By using the active metabolite 5 as an initial template, further structural modifications led to the identification of the titled compound 24 (BPR-890) as a highly potent CB1 inverse agonist possessing an excellent CB2/1 selectivity and remarkable in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dac6e20afdcf3fb9a8eaeaa8d2478da8
https://doi.org/10.1021/jm900471u
https://doi.org/10.1021/jm900471u