Zobrazeno 1 - 10
of 124
pro vyhledávání: '"Ming Chang, Hu"'
Autor:
Toshiharu Onodera, May-Yun Wang, Joseph M. Rutkowski, Stanislaw Deja, Shiuhwei Chen, Michael S. Balzer, Dae-Seok Kim, Xuenan Sun, Yu A. An, Bianca C. Field, Charlotte Lee, Ei-ichi Matsuo, Monika Mizerska, Ina Sanjana, Naoto Fujiwara, Christine M. Kusminski, Ruth Gordillo, Laurent Gautron, Denise K. Marciano, Ming Chang Hu, Shawn C. Burgess, Katalin Susztak, Orson W. Moe, Philipp E. Scherer
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-20 (2023)
Abstract Adiponectin is a secretory protein, primarily produced in adipocytes. However, low but detectable expression of adiponectin can be observed in cell types beyond adipocytes, particularly in kidney tubular cells, but its local renal role is un
Externí odkaz:
https://doaj.org/article/6885cd75dd3641e481d840972315e815
Publikováno v:
FASEB BioAdvances, Vol 3, Iss 7, Pp 531-540 (2021)
ABSTRACT Alpha‐Klotho is a multi‐functional protein essential for maintenance of a myriad of cell functions. αKlotho is a single transmembrane protein with a large extracellular segment consisting of two domains (termed Kl1 and Kl2) which is she
Externí odkaz:
https://doaj.org/article/cab31ac6734a4d9e93b5fc9c82173616
Autor:
Javier A. Neyra, Ming-Chang Hu, Abu Minhajuddin, Geoffrey E. Nelson, Syed A. Ahsan, Robert D. Toto, Michael E. Jessen, Orson W. Moe, Amanda A. Fox
Publikováno v:
Kidney International Reports, Vol 4, Iss 8, Pp 1131-1142 (2019)
Background: Cardiac surgery–associated acute kidney injury (AKI) is associated with increased morbidity and mortality. We examined the utility of combining biomarkers of kidney function loss (serum cystatin C) and kidney tubular damage (urine neutr
Externí odkaz:
https://doaj.org/article/7c147e81f23244c489099cf72381517d
Autor:
Jenny Maique, Brianna Flores, Mingjun Shi, Sierra Shepard, Zhiyong Zhou, Shirely Yan, Orson W. Moe, Ming Chang Hu
Publikováno v:
Frontiers in Pharmacology, Vol 11 (2020)
Cellular senescence is an irreversible cell growth arrest and is associated with aging and age-related diseases. High plasma phosphate (Pi) and deficiency of Klotho contribute to aging and kidney fibrosis, a pathological feature in the aging kidney a
Externí odkaz:
https://doaj.org/article/bafa2c302a444344b004eb9b66a0a4c8
Autor:
Mingjun Shi, Sierra Shepard, Zhiyong Zhou, Jenny Maique, Olivia Seli, Orson W. Moe, Ming Chang Hu
Publikováno v:
Cells, Vol 10, Iss 4, p 777 (2021)
High phosphate contributes to uremic cardiomyopathy. Abnormal autophagy is associated with the development and progression of heart disease. What is unknown is the effects of phosphate on autophagy and whether the ill effects of phosphate on cardiomy
Externí odkaz:
https://doaj.org/article/06bdd40e965c45fc837ba48c5fee227c
Publikováno v:
Kidney International. 101:63-78
Autophagy regulator beclin 1 activity determines the severity of kidney damage induced by ischemia reperfusion injury, but its role in kidney recovery and fibrosis are unknown and its therapeutic potentials have not been tested. Here, we explored bec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25ce878f9b69cc163a89c6ce938c652f
https://doi.org/10.1016/j.kint.2021.09.030
https://doi.org/10.1016/j.kint.2021.09.030
Publikováno v:
American journal of physiology. Renal physiology.
This research paper studied the interplay of vascular endothelial growth factor receptor type 2 (VEGFR2), high dietary phosphate, and Klotho, an antiaging protein, in peritubular structure and kidney fibrosis. Klotho protein was shown to maintain VEG
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f74e8a1e18030f99f7d371e1277f740e
https://pubmed.ncbi.nlm.nih.gov/36395384
https://pubmed.ncbi.nlm.nih.gov/36395384
Publikováno v:
FASEB BioAdvances, Vol 3, Iss 7, Pp 531-540 (2021)
FASEB BioAdvances
FASEB BioAdvances
Alpha‐Klotho is a multi‐functional protein essential for maintenance of a myriad of cell functions. αKlotho is a single transmembrane protein with a large extracellular segment consisting of two domains (termed Kl1 and Kl2) which is shed into th
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8987bd14acb2d75bac0b88eb07a2d3f
https://doaj.org/article/cab31ac6734a4d9e93b5fc9c82173616
https://doaj.org/article/cab31ac6734a4d9e93b5fc9c82173616
Autor:
Ao Bian, Mingjun Shi, Brianna Flores, Nancy Gillings, Peng Li, Shirley Xiao Yan, Beth Levine, Changying Xing, Ming Chang Hu
Publikováno v:
PLoS ONE, Vol 12, Iss 9, p e0181848 (2017)
C-reactive protein (CRP), was recently reported to be closely associated with poor renal function in patients with acute kidney injury (AKI), but whether CRP is pathogenic or a mere biomarker in AKI remains largely unclear. Impaired autophagy is know
Externí odkaz:
https://doaj.org/article/fa6df8e74c2a4d80ab8d3438e9bf71a3
Autor:
Kenneth B. Gagnon, Adrienne Bushau‐Sprinkle, Ming‐Chang Hu, Audrey N. Chang, R T. Miller, Eleanor D. Lederer
Publikováno v:
The FASEB Journal. 36
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9756d3b3f579255edd254963b874b5e3
https://doi.org/10.1096/fasebj.2022.36.s1.r4710
https://doi.org/10.1096/fasebj.2022.36.s1.r4710