Zobrazeno 1 - 10
of 1 038
pro vyhledávání: '"Ming‐Sound Tsao"'
Autor:
Ellen Yang, MD, FRCPC, Najd Alshamlan, MD, Katrina Hueniken, MSc, Jessica Weiss, MSc, Michael Cabanero, MD, Ming-Sound Tsao, MD, FRCPC
Publikováno v:
JTO Clinical and Research Reports, Vol 5, Iss 7, Pp 100682- (2024)
Introduction: Lepidic growth is considered noninvasive in lung nonmucinous adenocarcinoma, whereas other patterns are invasive. Considerable interobserver variability in assessing “invasion” has been reported. We assessed the utility of cytokerat
Externí odkaz:
https://doaj.org/article/7c10847babb54e9cab8465002c004d7d
Autor:
Mohamed Bourmoum, Nikolina Radulovich, Amit Sharma, Johnny M Tkach, Ming-Sound Tsao, Laurence Pelletier
Publikováno v:
PLoS ONE, Vol 19, Iss 2, p e0295030 (2024)
Colorectal cancer is the third most common cancer and the second leading cause of cancer-related deaths worldwide. The centrosome is the main microtubule-organizing center in animal cells and centrosome amplification is a hallmark of cancer cells. To
Externí odkaz:
https://doaj.org/article/2ed4175e77cb4cff86ba7f89c0480ecb
Autor:
Kaitlin H. Chen, BSc, Tristan A. Barnes, MD, BS, Janessa Laskin, MD, Parneet Cheema, MD, MBiotech, Geoffrey Liu, MD, MS, Mussawar Iqbal, MD, Jeffrey Rothenstein, MD, Ronald Burkes, MD, Ming-Sound Tsao, MD, Natasha B. Leighl, MD, MMSc
Publikováno v:
JTO Clinical and Research Reports, Vol 5, Iss 1, Pp 100615- (2024)
Introduction: Liquid biopsy is recommended to diagnose molecular resistance to targeted therapy in patients with lung cancer. Nevertheless, not all jurisdictions provide funding and patient access. We report patients’ perceived value of liquid biop
Externí odkaz:
https://doaj.org/article/bb83005dd58b4c3492bec95a48fdc8a9
Autor:
Kamdin Mirsanaye, Leonardo Uribe Castaño, Yasmeen Kamaliddin, Ahmad Golaraei, Lukas Kontenis, Edvardas Ẑurauskas, Roya Navab, Kazuhiro Yasufuku, Ming-Sound Tsao, Brian C. Wilson, Virginijus Barzda
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract The extracellular matrix (ECM) is amongst many tissue components affected by cancer, however, morphological changes of the ECM are not well-understood and thus, often omitted from diagnostic considerations. Polarimetric second-harmonic gener
Externí odkaz:
https://doaj.org/article/658ac9a3764a4af08435107b2ccd7fee
Autor:
Shideh Mirhadi, Shirley Tam, Quan Li, Nadeem Moghal, Nhu-An Pham, Jiefei Tong, Brian J. Golbourn, Jonathan R. Krieger, Paul Taylor, Ming Li, Jessica Weiss, Sebastiao N. Martins-Filho, Vibha Raghavan, Yasin Mamatjan, Aafaque A. Khan, Michael Cabanero, Shingo Sakashita, Kugeng Huo, Sameer Agnihotri, Kota Ishizawa, Thomas K. Waddell, Gelareh Zadeh, Kazuhiro Yasufuku, Geoffrey Liu, Frances A. Shepherd, Michael F. Moran, Ming-Sound Tsao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-17 (2022)
With non-small cell lung cancer (NSCLC) being the leading cause of cancer deaths worldwide, the development of targeted therapies remains crucial. Here, the generation and multi-omics characterization of 137 NSCLC patient-derived xenografts provides
Externí odkaz:
https://doaj.org/article/ca6f25a2b4ee419cb65ec4d91e659e4f
Publikováno v:
Therapeutic Advances in Medical Oncology, Vol 15 (2023)
Kirsten rat sarcoma viral oncogene homolog mutations are observed in 25% of lung adenocarcinoma and 40% of these are G12C mutations. Historically, no approved targeted agents were available for patients with any KRAS mutation, and response rates to s
Externí odkaz:
https://doaj.org/article/a72cd08431844f868d2e8b1e1cddf4db
Autor:
Teklab Gebregiworgis, Yoshihito Kano, Jonathan St-Germain, Nikolina Radulovich, Molly L. Udaskin, Ahmet Mentes, Richard Huang, Betty P. K. Poon, Wenguang He, Ivette Valencia-Sama, Claire M. Robinson, Melissa Huestis, Jinmin Miao, Jen Jen Yeh, Zhong-Yin Zhang, Meredith S. Irwin, Jeffrey E. Lee, Ming-Sound Tsao, Brian Raught, Christopher B. Marshall, Michael Ohh, Mitsuhiko Ikura
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
SHP2 promotes RAS-driven MAPK signalling, but it is unclear why cancer cells with distinct KRAS mutations exhibit differential sensitivity to SHP2 inhibition. Here the authors show that KRAS Q61H is decoupled from SHP2- mediated upstream regulation,
Externí odkaz:
https://doaj.org/article/adc5eaa39af340409424aef1fcf1144b
Autor:
Jessica Weiss, Nhu-An Pham, Melania Pintilie, Ming Li, Geoffrey Liu, Frances A Shepherd, Ming-Sound Tsao, Wei Xu
Publikováno v:
Cancer Informatics, Vol 21 (2022)
Patient-derived tumor xenograft (PDX) models were used to evaluate the effectiveness of preclinical anticancer agents. A design using 1 mouse per patient per drug (1 × 1 × 1) was considered practical for large-scale drug efficacy studies. We evalua
Externí odkaz:
https://doaj.org/article/a39d203b5f3d46508161c69091c20787
Autor:
Maisam Makarem, Doreen A. Ezeife, Adam C. Smith, Janice J. N. Li, Jennifer H. Law, Ming-Sound Tsao, Natasha B. Leighl
Publikováno v:
Current Oncology, Vol 28, Iss 5, Pp 3268-3279 (2021)
ROS1 rearrangements are identified in 1–2% of lung adenocarcinoma cases, and reflex testing is guideline-recommended. We developed a decision model for population-based ROS1 testing from a Canadian public healthcare perspective to determine the str
Externí odkaz:
https://doaj.org/article/e93481a624f5442e94ebd6f4eb8c6fbc
Autor:
Iram Siddiqui, Jade Bilkey, Trevor D. McKee, Stefano Serra, Melania Pintilie, Trevor Do, Jing Xu, Ming-Sound Tsao, Steve Gallinger, Richard P. Hill, David W. Hedley, Neesha C. Dhani
Publikováno v:
Frontiers in Oncology, Vol 12 (2022)
BackgroundTumor hypoxia is theorized to contribute to the aggressive biology of pancreatic ductal adenocarcinoma (PDAC). We previously reported that hypoxia correlated with rapid tumor growth and metastasis in patient-derived xenografts. Anticipating
Externí odkaz:
https://doaj.org/article/5add2d3f4e1b40eaa01da29e4b140543