Zobrazeno 1 - 10
of 28
pro vyhledávání: '"Minfei, Su"'
Publikováno v:
Experimental and Molecular Medicine, Vol 56, Iss 9, Pp 1952-1966 (2024)
Abstract Agonists targeting α2-adrenergic receptors (ARs) are used to treat diverse conditions, including hypertension, attention-deficit/hyperactivity disorder, pain, panic disorders, opioid and alcohol withdrawal symptoms, and cigarette cravings.
Externí odkaz:
https://doaj.org/article/39057a4010c94a3f87205a27fe7825f5
Autor:
Minfei Su, Jinan Wang, Guoqing Xiang, Hung Nguyen Do, Joshua Levitz, Yinglong Miao, Xin-Yun Huang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-12 (2023)
Abstract α1-adrenergic receptors (α1-ARs) play critical roles in the cardiovascular and nervous systems where they regulate blood pressure, cognition, and metabolism. However, the lack of specific agonists for all α1 subtypes has limited our under
Externí odkaz:
https://doaj.org/article/63dfe8288c9a4a048a21d6655a5086b0
Autor:
Minfei Su, Navid Paknejad, Lan Zhu, Jinan Wang, Hung Nguyen Do, Yinglong Miao, Wei Liu, Richard K. Hite, Xin-Yun Huang
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-13 (2022)
Su et al. report cryo-EM structures of β1-adrenergic receptor, Gs and ligands of different efficacies. These complexes have similar overall architecture, but with local conformational differences and different stabilities.
Externí odkaz:
https://doaj.org/article/c1df6479c5ba4cfb9c48c1795f9bfd9e
Autor:
Joel R. Meyerson, Richard K Hite, Edward T. Eng, Jian-Shu Lou, Jianyun Huang, Kelsey D. Jordan, Xin-Yun Huang, Minfei Su, Kamela O. Alegre, Navid Paknejad
Publikováno v:
Nat Struct Mol Biol
The β1-adrenergic receptor (β1-AR) can activate two families of G proteins. When coupled to Gs, β1-AR increases cardiac output, and coupling to Gi leads to decreased responsiveness in myocardial infarction. By comparative structural analysis of tu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dbbaffe1f5d6ad2bd526fed3095666b2
https://doi.org/10.1038/s41594-021-00679-2
https://doi.org/10.1038/s41594-021-00679-2
Autor:
Yongjie Wei, Zhenyi An, Zhongju Zou, Rhea Sumpter Jr, Minfei Su, Xiao Zang, Sangita Sinha, Matthias Gaestel, Beth Levine
Publikováno v:
eLife, Vol 4 (2015)
Autophagy is a fundamental adaptive response to amino acid starvation orchestrated by conserved gene products, the autophagy (ATG) proteins. However, the cellular cues that activate the function of ATG proteins during amino acid starvation are incomp
Externí odkaz:
https://doaj.org/article/15fcd3fe32104bc7974d2e4d5acd44a3
Autor:
Minfei, Su, Navid, Paknejad, Lan, Zhu, Jinan, Wang, Hung Nguyen, Do, Yinglong, Miao, Wei, Liu, Richard K, Hite, Xin-Yun, Huang
Publikováno v:
Nature communications. 13(1)
G-protein-coupled receptors (GPCRs) receive signals from ligands with different efficacies, and transduce to heterotrimeric G-proteins to generate different degrees of physiological responses. Previous studies revealed how ligands with different effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::1a94e7869f3ad6837572348bbe916cdb
https://pubmed.ncbi.nlm.nih.gov/35835792
https://pubmed.ncbi.nlm.nih.gov/35835792
Autor:
Minfei, Su, Lan, Zhu, Yixiao, Zhang, Navid, Paknejad, Raja, Dey, Jianyun, Huang, Ming-Yue, Lee, Dewight, Williams, Kelsey D, Jordan, Edward T, Eng, Oliver P, Ernst, Joel R, Meyerson, Richard K, Hite, Thomas, Walz, Wei, Liu, Xin-Yun, Huang
Publikováno v:
Mol Cell
In this issue of Molecular Cell, Su et al. (2020) report a cryo-EM structure of the β1-adrenergic receptor (β1AR) in complex with a heterotrimeric Gs protein, which offers novel insights into receptor activation and provides a structural framework
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::0d0b87a63384c652ab3b53af32da2186
https://pubmed.ncbi.nlm.nih.gov/33007256
https://pubmed.ncbi.nlm.nih.gov/33007256
Autor:
Dewight Williams, Kelsey D. Jordan, Navid Paknejad, Ming-Yue Lee, Joel R. Meyerson, Thomas Walz, Xin-Yun Huang, Yixiao Zhang, Lan Zhu, Edward T. Eng, Minfei Su, Wei Liu, Richard K Hite, Jianyun Huang, Oliver P. Ernst, Raja Dey
Publikováno v:
Molecular Cell. 80:59-71.e4
Cardiac disease remains the leading cause of morbidity and mortality worldwide. The β1-adrenergic receptor (β1-AR) is a major regulator of cardiac functions and is downregulated in the majority of heart failure cases. A key physiological process is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a6f862d7e8f20493f486b5b7b49f7a63
https://doi.org/10.1016/j.molcel.2020.08.001
https://doi.org/10.1016/j.molcel.2020.08.001
Autor:
Yue Li, Srinivas Chakravarthy, Karen Glover, Minfei Su, Yuting Zhao, Sangita C. Sinha, Christopher L. Colbert, Beth Levine
Mammalian Golgi-associated plant pathogenesis-related protein 1 (GAPR-1) is a negative autophagy regulator that binds Beclin 1, a key component of the autophagosome nucleation complex. Beclin 1 residues 267–284 are required for binding GAPR-1. Here
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2fbf9ada3c03f27019981a92d6acd3df
https://europepmc.org/articles/PMC5586249/
https://europepmc.org/articles/PMC5586249/
Autor:
Ruslan Sanishvili, Christopher L. Colbert, Beth Levine, Sangita C. Sinha, Minfei Su, Yang Mei
Publikováno v:
Journal of Biological Chemistry. 289:8029-8040
γ-herpesviruses (γHVs) are common human pathogens that encode homologs of the anti-apoptotic cellular Bcl-2 proteins, which are critical to viral reactivation and oncogenic transformation. The murine γHV68 provides a tractable in vivo model for un
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c92429355ad70be660aeebbb8190e2c6
https://doi.org/10.1074/jbc.m113.515361
https://doi.org/10.1074/jbc.m113.515361