Výsledky vyhledávání - "Minezo Otsuka"

In Vitro Evaluation of Drug Interaction Caused by Enzyme Inhibition. HAB Protocol

Publikováno v: Drug Metabolism and Pharmacokinetics. 16:115-126

Protocols for evaluating drug interaction caused by enzyme inhibition were established by the Drug Interaction Database Working Group of the Human and Animal Bridge Discussion Group (HAB). Basically, procedures for measurements of the inhibition cons

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::48cf344263c84a5664b690a7501c7793
https://doi.org/10.2133/dmpk.16.115

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Characterization of a novel variant (S145C/L311V) of 3 ??-hydroxysteroid/dihydrodiol dehydrogenase in human liver

Autor: Tomoyuki Terada, Harunori Iwasa, Minezo Otsuka, Tetsuya Takagi, Akira Hara, Tetsuya Kamataki, Toshiyuki Kume, Kazuo Nagashima, Tsuyoshi Yokoi, Hiroaki Shiraishi

Publikováno v: Pharmacogenetics and Genomics. 9:763-772

Human liver 3alpha-hydroxysteroid/dihydrodiol dehydrogenase (DD) is involved in the metabolism of steroid hormones and polycyclic aromatic hydrocarbons, and is also responsible for the reduction of ketone-containing drugs. To account for the interind

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083624df8ead16958524676898288db9
https://doi.org/10.1097/01213011-199912000-00011

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Binding characteristics of a new 1,5-benzothiazepine, clentiazem, to rat cerebral cortex and skeletal muscle membranes

Autor: Osasi Takaiti, Minezo Otsuka, Tatsuo Suzuki, Motoaki Ohashi, Hideo Kurosawa, Kazuaki Naito

Publikováno v: European journal of pharmacology. 194(2-3)

The binding properties of a new 1,5-benzothiazepine, clentiazem (TA-3090), were investigated in rat cerebral cortex and skeletal muscle membranes with [3H]diltiazem and [3H]nitrendipine as radioligands. Clentiazem inhibited [3H]diltiazem binding to c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4bf82559026809e42780895380a730a8
https://pubmed.ncbi.nlm.nih.gov/2060600

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Synthesis of the metabolites of afloqualone and related compounds

Autor: Toyonari Oine, Minezo Otsuka, Junichi Tani, Yoshihisa Yamada

Publikováno v: Chemical and Pharmaceutical Bulletin. 31:1158-1165

Seven main metabolites (3-9) of afloqualone (1, 6-amino-2-fluoromethyl-3-(o-tolyl)-4 (3H)-quinazolinone and related 4 (3H)-quinazolinone derivatives were synthesized. The metabolites 4 and 5 containing a sulfur atom were prepared by the reaction of 6

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d632ad17a8bb4c54035c19470a9f600
https://doi.org/10.1248/cpb.31.1158

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Metabolic fate of the new .BETA.-adrenoceptor antagonist, bisoprolol, in animals (3): Foeto-placental transfer and excretion into milk of 14C-bisoprolol in rats

Autor: Minezo Otsuka, Osasi Takaiti, Kazuaki Naito, Yasuhiro Yamada, Michihiro Kohno, Mika Nakahara

Publikováno v: Drug Metabolism and Pharmacokinetics. 4:173-185

Foeto-placental transfer and excretion of bisoprolol into milk were studied in pregnant rats and lactating rats after the oral or intravenous administration of 14C-bisoprolol (1 mg/kg)1. When 14C-bisoprolol was orally or intravenously administered to

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::fdcaa6cf2beaf14c8275cffdefe1a678
https://doi.org/10.2133/dmpk.4.173

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