Zobrazeno 1 - 10
of 53
pro vyhledávání: '"Mineto Ota"'
Autor:
Yasuhiro Tagawa, Tetsuya Saito, Hideyuki Iwai, Motohiko Sato, Seiji Noda, Akio Yamamoto, Mineto Ota, Kentaro Endo, Hideyuki Koga, Yasuhiro Takahara, Kazutaka Sugimoto, Ichiro Sekiya, Keishi Fujio, Eiryo Kawakami, Fumitaka Mizoguchi, Shinsuke Yasuda
Publikováno v:
Immunological Medicine, Vol 47, Iss 3, Pp 176-185 (2024)
Recent single-cell RNA-sequencing analysis of rheumatoid arthritis (RA) synovial tissues revealed the heterogeneity of RA synovial fibroblasts (SFs) with distinct functions such as high IL-6 production. The molecular mechanisms responsible for high I
Externí odkaz:
https://doaj.org/article/1cb40cc9da364f5fb0a8ec5d5e697aed
Autor:
Haruka Tsuchiya, Mineto Ota, Haruka Takahashi, Hiroaki Hatano, Megumi Ogawa, Sotaro Nakajima, Risa Yoshihara, Tomohisa Okamura, Shuji Sumitomo, Keishi Fujio
Publikováno v:
Inflammation and Regeneration, Vol 44, Iss 1, Pp 1-14 (2024)
Abstract Background Current strategies that target cytokines (e.g., tumor necrosis factor (TNF)-α), or signaling molecules (e.g., Janus kinase (JAK)) have advanced the management for allergies and autoimmune diseases. Nevertheless, the molecular mec
Externí odkaz:
https://doaj.org/article/13196c734eea4dd9af939d9a92a133c4
Autor:
Mariko Inoue, Yasuo Nagafuchi, Mineto Ota, Haruka Tsuchiya, Shoko Tateishi, Hiroko Kanda, Keishi Fujio
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-9 (2023)
Abstract HLA-DRB1 shared epitope risk alleles are the strongest genetic risk factors for rheumatoid arthritis (RA) and potential biomarkers for treatment response to biological disease-modifying antirheumatic drugs (bDMARDs). This study aimed to inve
Externí odkaz:
https://doaj.org/article/56cbc4b0b6a841e8ad9bc7ba693420e6
Publikováno v:
Frontiers in Immunology, Vol 15 (2024)
B cells play a crucial role in the immune response and contribute to various autoimmune diseases. Recent studies have revealed abnormalities in the B cell receptor (BCR) repertoire of patients with autoimmune diseases, with distinct features observed
Externí odkaz:
https://doaj.org/article/4dbb1799af49490abadbec4ee513c93c
Autor:
Yusuke Sugimori, Yukiko Iwasaki, Yusuke Takeshima, Mai Okubo, Satomi Kobayashi, Hiroaki Hatano, Saeko Yamada, Masahiro Nakano, Ryochi Yoshida, Mineto Ota, Yumi Tsuchida, Yasuo Nagafuchi, Kenichi Shimane, Ken Yoshida, Daitaro Kurosaka, Shuji Sumitomo, Hirofumi Shoda, Kazuhiko Yamamoto, Tomohisa Okamura, Keishi Fujio
Publikováno v:
ACR Open Rheumatology, Vol 5, Iss 2, Pp 93-102 (2023)
Objective Idiopathic inflammatory myopathies (IIM) demonstrate characteristic clinical phenotypes depending on the myositis‐specific antibody (MSAs) present. We aimed to identify common or MSA‐specific immunological pathways in different immune c
Externí odkaz:
https://doaj.org/article/626aacd816f943d48915decde6481c58
Autor:
Norio Hanata, Mineto Ota, Yumi Tsuchida, Yasuo Nagafuchi, Tomohisa Okamura, Hirofumi Shoda, Keishi Fujio
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-14 (2022)
Abstract Neutrophil extracellular traps (NETs) are involved in systemic lupus erythematosus (SLE). We sought to cluster SLE patients based on serum NET levels. Serum NET levels were higher in SLE patients than healthy controls. Frequencies of pleurit
Externí odkaz:
https://doaj.org/article/20eab43eb1c5401fb8df37f93bce6dde
Autor:
Mai Okubo, Shuji Sumitomo, Yumi Tsuchida, Yasuo Nagafuchi, Yusuke Takeshima, Haruyuki Yanaoka, Harumi Shirai, Satomi Kobayashi, Yusuke Sugimori, Junko Maeda, Hiroaki Hatano, Yukiko Iwasaki, Hirofumi Shoda, Tomohisa Okamura, Kazuhiko Yamamoto, Mineto Ota, Keishi Fujio
Publikováno v:
Arthritis Research & Therapy, Vol 24, Iss 1, Pp 1-12 (2022)
Abstract Background Behçet’s syndrome (BS) is an immune-mediated disease characterized by recurrent oral ulcers, genital ulcers, uveitis, and skin symptoms. HLA-B51, as well as other genetic polymorphisms, has been reported to be associated with B
Externí odkaz:
https://doaj.org/article/98e13650dc0e400799ee89bcc981c0ed
Autor:
Mineto Ota, Keishi Fujio
Publikováno v:
Inflammation and Regeneration, Vol 41, Iss 1, Pp 1-6 (2021)
Abstract Recent innovation in high-throughput sequencing technologies has drastically empowered the scientific research. Consequently, now, it is possible to capture comprehensive profiles of samples at multiple levels including genome, epigenome, an
Externí odkaz:
https://doaj.org/article/b1b5e2c8c82541dabb19597fff661d25
Publikováno v:
Inflammation and Regeneration, Vol 41, Iss 1, Pp 1-6 (2021)
Abstract Background Rheumatoid arthritis (RA) is an autoimmune disease characterized by tumor-like hyperplasia and inflammation of the synovium, which causes synovial cell invasion into the bone and cartilage. In RA pathogenesis, various molecules in
Externí odkaz:
https://doaj.org/article/e2f83ea43506432284141358ccfda2c0
Autor:
Shuji Sumitomo, Yasuo Nagafuchi, Yumi Tsuchida, Haruka Tsuchiya, Mineto Ota, Kazuyoshi Ishigaki, Akari Suzuki, Yuta Kochi, Keishi Fujio, Kazuhiko Yamamoto
Publikováno v:
Inflammation and Regeneration, Vol 38, Iss 1, Pp 1-5 (2018)
Abstract In the era of precision medicine, transcriptome analysis of whole gene expression is an essential technology. While DNA microarray has a limited dynamic range and a problem of background hybridization, RNA sequencing (RNA-seq) has a broader
Externí odkaz:
https://doaj.org/article/db90aea427ec4d6cba14bb9feb21abcf