Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Minervo Perez"'
Autor:
Minervo Perez, Jordan L. Meier
Publikováno v:
Nature. 616:670-671
Autor:
Minervo Perez, Kellie D. Nance, Daniel W. Bak, Supuni Thalalla Gamage, Susana S. Najera, Amy N. Conte, W. Marston Linehan, Eranthie Weerapana, Jordan L. Meier
Hereditary leiomyomatosis and renal cell carcinoma (HLRCC) is a cancer predisposition syndrome driven by mutation of the tumor suppressor fumarate hydratase (FH). Inactivation of FH causes accumulation of the electrophilic oncometabolite fumarate. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6b8b59722cfbb4551988b8c9048893d
https://doi.org/10.1101/2022.04.26.489575
https://doi.org/10.1101/2022.04.26.489575
Autor:
W. Marston Linehan, Daniel R. Crooks, Sarah E. Bergholtz, Youfeng Yang, Daniel W. Bak, Bhargav Srinivas Arimilli, Eranthie Weerapana, Jordan L. Meier, Minervo Perez
Publikováno v:
J Biol Chem
An important context in which metabolism influences tumorigenesis is the genetic cancer syndrome hereditary leiomyomatosis and renal cell carcinoma (HLRCC), a disease in which mutation of the tricarboxylic acid cycle enzyme fumarate hydratase (FH) ca
Dissertation/ Thesis
Autor:
Minervo Perez (5930141)
The use of computational approaches to understand kinase substrate preference has been a powerful tool in the search to develop artificial peptide probes to monitor kinase activity, however, most of these efforts focus on a small portion of the human
Publikováno v:
Molecular & Cellular Proteomics. 18:477-489
SummaryAcute myeloid leukemia (AML) is an aggressive disease that is characterized by abnormal increase of immature myeloblasts in blood and bone marrow. The FLT3 receptor tyrosine kinase plays an integral role in haematopoiesis, and one third of AML
Autor:
Minervo Perez
The use of computational approaches to understand kinase substrate preference has been a powerful tool in the search to develop artificial peptide probes to monitor kinase activity, however, most of these efforts focus on a small portion of the human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c53cbff5b358500142971a9b510184e
Autor:
Sarah E. Bergholtz, Daniel W. Bak, Youfeng Yang, W. Marston Linehan, Minervo Perez, Jordan L. Meier, Eranthie Weerapana, Daniel R. Crooks
Metabolism and signaling intersect in the genetic cancer syndrome hereditary leiomyomatosis and renal cell carcinoma (HLRCC), a disease in which mutation of the TCA cycle enzyme fumarate hydratase (FH) causes hyperaccumulation of fumarate. This elect
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a14a67594aea988add9b2bdd24411f59
https://doi.org/10.1101/2020.06.25.171843
https://doi.org/10.1101/2020.06.25.171843
Autor:
W. Marston Linehan, Susana S. Najera, Chloe A. Briney, Sarah E. Bergholtz, Jordan L. Meier, Minervo Perez
Publikováno v:
ACS Chem Biol
Metabolites regulate protein function via covalent and non-covalent interactions. However, manipulating these interactions in living cells remains a major challenge. Here we report a chemical strategy for inducing cysteine S-succination, a non-enzyma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::30cf262dda0ca54f2b1b292361d3e91d
https://doi.org/10.1101/2020.01.11.902973
https://doi.org/10.1101/2020.01.11.902973
Lipid Droplet-Derived Monounsaturated Fatty Acids Traffic via PLIN5 to Allosterically Activate SIRT1
Autor:
Mallory P. Franklin, Mark J. Graham, Linnea E. Mead, Timothy D. Heden, Kenneth K. Karanja, Bruce A. Witthuhn, Laurie L. Parker, Charles P. Najt, Douglas G. Mashek, Lisa S. Chow, Minervo Perez, Mara T. Mashek, Jason L. Heier, Salmaan A. Khan, David A. Bernlohr
Publikováno v:
Mol Cell
Lipid droplets (LDs) provide a reservoir for triacylglycerol storage and are a central hub for fatty acid trafficking and signaling in cells. Lipolysis promotes mitochondrial biogenesis and oxidative metabolism via a SIRT1/PGC-1α/PPARα-dependent pa
Publikováno v:
Analytical Chemistry. 87:7555-7558
Kinase signaling is a major mechanism driving many cancers. While many inhibitors have been developed and are employed in the clinic, resistance due to crosstalk and pathway reprogramming is an emerging problem. High-throughput assays to detect multi