Abstract NG14: Dissecting immune microenvironment of T-cell acute lymphoblastic leukemia

Autor: Mark Gower, Minerva Fernandez, Andrea Aruda, Mark Minden, Johann Hitzler, Anastasia Tikhonova

Publikováno v: Cancer Research. 83:NG14-NG14

T-cell acute lymphoblastic leukemia (T-ALL) represents a particularly aggressive subtype of leukemia with no targeted therapies or immune interventions. Currently, in response to intensive chemotherapy, ~25% of pediatric and 50% of adult patients und

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::a69b36ffaa90500746fd20438598918b
https://doi.org/10.1158/1538-7445.am2023-ng14

Next-generation sequencing identifies rare variants associated with Noonan syndrome

Autor: Quang M. Trinh, Christina K. Yung, Raju Kucherlapati, Lincoln Stein, Hui Wen Yu, Minerva Fernandez, Donna M. Muzny, Tao Yuan, Richard A. Gibbs, Amy E. Roberts, Jiani C. Yin, Vanya Peltekova, Benjamin G. Neel, Erica Tworog-Dube, Jeffrey G. Reid, Margaret Morgan, Peng Chieh Chen, John Douglas Mcpherson

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America, vol 111, iss 31

Noonan syndrome (NS) is a relatively common genetic disorder, characterized by typical facies, short stature, developmental delay, and cardiac abnormalities. Known causative genes account for 70-80% of clinically diagnosed NS patients, but the geneti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d4002ff78edacbee8b7572ac9721e12f
https://doi.org/10.1073/pnas.1324128111

Structure-guided engineering fine-tunes pharmacokinetics, tolerability and anti-tumor profile of anti-frizzled antibody

Autor: Zainab Haybe, Mark Ng, Melissa Beilschmidt, Minh D. To, Kevin K. Lin, Jeanne Magram, James Pan, Jean-Philippe Julien, Yazen Jmeian, Sachdev S. Sidhu, Johan E. S. Fransson, Stephane Angers, Jason Moffat, Angus Sinclair, Minerva Fernandez, Swetha Raman, Keith Mascall, Ying Fu, Francine Lui

Publikováno v: Acta Crystallographica Section A Foundations and Advances. 74:a297-a297

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::7b57353fdf1804a157c54bcf4db9c9a2
https://doi.org/10.1107/s0108767318097039

Cloning of a novel phosphotyrosine binding domain containing molecule, Odin, involved in signaling by receptor tyrosine kinases

Autor: Serge Roche, Minerva Fernandez, Alexandre V. Podtelejnikov, Troels Z. Kristiansen, Blagoy Blagoev, Irina Kratchmarova, Matthias Mann, Akhilesh Pandey, Osamu Ohara, Mogens Brøndsted Nielsen, Harvey F. Lodish

Publikováno v: Oncogene. 21(52)

We have used a proteomic approach using mass spectrometry to identify signaling molecules involved in receptor tyrosine kinase signaling pathways. Using affinity purification by anti-phosphotyrosine antibodies to enrich for tyrosine phosphorylated pr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d4fcf963b29e38a840e320bfe8d6a7
https://pubmed.ncbi.nlm.nih.gov/12439753

Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway

Autor: Akhilesh Pandey, Hanno Steen, Minerva Fernandez, Bernhard Kuster, Matthias Mann

Publikováno v: Steen, H, Kuster, B, Fernandez, M, Pandey, A & Mann, M 2002, ' Tyrosine phosphorylation mapping of the epidermal growth factor receptor signaling pathway ', Journal of Biological Chemistry, vol. 277(2), pp. 1031-39 .

Phosphorylation is one of the most common forms of protein modification. The most frequent targets for protein phosphorylation in eukaryotes are serine and threonine residues, although tyrosine residues also undergo phosphorylation. Many of the curre

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a0de7d9c68e574086882ae9f7a7f8a9
https://pubmed.ncbi.nlm.nih.gov/11687594