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Assessment of neurovascular uncoupling: APOE status is a key driver of early metabolic and vascular dysfunction.

Autor: Onos KD; The Jackson Laboratory, Bar Harbor, Maine, USA., Lin PB; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Neurology, Washington University in St. Louis, St. Louis, Missouri, USA., Pandey RS; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA., Persohn SA; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA., Burton CP; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA., Miner EW; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA., Eldridge K; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA., Kanyinda JN; The Jackson Laboratory, Bar Harbor, Maine, USA., Foley KE; The Jackson Laboratory, Bar Harbor, Maine, USA.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA., Carter GW; The Jackson Laboratory, Bar Harbor, Maine, USA.; The Jackson Laboratory for Genomic Medicine, Farmington, Connecticut, USA., Howell GR; The Jackson Laboratory, Bar Harbor, Maine, USA., Territo PR; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, Indiana, USA.; Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis, Indiana, USA.

Publikováno v: Alzheimer's & dementia : the journal of the Alzheimer's Association [Alzheimers Dement] 2024 Jul; Vol. 20 (7), pp. 4951-4969. Date of Electronic Publication: 2024 May 07.

Assessment of Neurovascular Uncoupling: APOE Status is a Key Driver of Early Metabolic and Vascular Dysfunction.

Autor: Onos K; The Jackson Laboratory, Bar Harbor, ME 04609 USA., Lin PB; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202 USA.; Department of Neurology, Washington University in St. Louis, St. Louis, MO, USA., Pandey RS; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032 USA., Persohn SA; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202 USA., Burton CP; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202 USA., Miner EW; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202 USA., Eldridge K; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202 USA., Kanyinda JN; The Jackson Laboratory, Bar Harbor, ME 04609 USA., Foley KE; The Jackson Laboratory, Bar Harbor, ME 04609 USA.; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202 USA., Carter GW; The Jackson Laboratory, Bar Harbor, ME 04609 USA.; The Jackson Laboratory for Genomic Medicine, Farmington, CT 06032 USA., Howell GR; The Jackson Laboratory, Bar Harbor, ME 04609 USA., Territo PR; Stark Neurosciences Research Institute, Indiana University School of Medicine, Indianapolis, IN 46202 USA.; Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, Indianapolis IN 46202 USA.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2024 Mar 13. Date of Electronic Publication: 2024 Mar 13.

Characterizing Molecular and Synaptic Signatures in mouse models of Late-Onset Alzheimer's Disease Independent of Amyloid and Tau Pathology.

Autor: Kotredes KP; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, United States, 04609., Pandey RS; The Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT, United States 06032., Persohn S; Indiana University School of Medicine, 340 W 10 Street, Indianapolis, IN, United States 46202.; Stark Neurosciences Research Institute, 320 W 15 Street, Indianapolis, IN, United States 46202., Elderidge K; Indiana University School of Medicine, 340 W 10 Street, Indianapolis, IN, United States 46202.; Stark Neurosciences Research Institute, 320 W 15 Street, Indianapolis, IN, United States 46202., Burton CP; Indiana University School of Medicine, 340 W 10 Street, Indianapolis, IN, United States 46202.; Stark Neurosciences Research Institute, 320 W 15 Street, Indianapolis, IN, United States 46202., Miner EW; Indiana University School of Medicine, 340 W 10 Street, Indianapolis, IN, United States 46202.; Stark Neurosciences Research Institute, 320 W 15 Street, Indianapolis, IN, United States 46202., Haynes KA; Department of Medicine, University of Pittsburgh Aging Institute, University of Pittsburgh School of Medicine, 100 Technology Drive, Pittsburgh, PA Pittsburgh, PA, United States 15219., Santos DFS; Department of Medicine, University of Pittsburgh Aging Institute, University of Pittsburgh School of Medicine, 100 Technology Drive, Pittsburgh, PA Pittsburgh, PA, United States 15219., Williams SP; Department of Medicine, University of Pittsburgh Aging Institute, University of Pittsburgh School of Medicine, 100 Technology Drive, Pittsburgh, PA Pittsburgh, PA, United States 15219., Heaton N; Department of Medicine, University of Pittsburgh Aging Institute, University of Pittsburgh School of Medicine, 100 Technology Drive, Pittsburgh, PA Pittsburgh, PA, United States 15219., Ingraham CM; Stark Neurosciences Research Institute, 320 W 15 Street, Indianapolis, IN, United States 46202., Lloyd C; Stark Neurosciences Research Institute, 320 W 15 Street, Indianapolis, IN, United States 46202., Garceau D; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, United States, 04609., O'Rourke R; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, United States, 04609., Herrick S; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, United States, 04609., Rangel-Barajas C; Indiana University School of Medicine, 340 W 10 Street, Indianapolis, IN, United States 46202.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, 410 W. 10 St., HITS 4000, Indianapolis, IN, United States 46202., Maharjan S; Indiana University School of Medicine, 340 W 10 Street, Indianapolis, IN, United States 46202.; Stark Neurosciences Research Institute, 320 W 15 Street, Indianapolis, IN, United States 46202.; Department of Radiology & Imaging Sciences, Indiana University School of Medicine, 550 University Blvd, Indianapolis, IN, United States 46202., Wang N; Indiana University School of Medicine, 340 W 10 Street, Indianapolis, IN, United States 46202.; Stark Neurosciences Research Institute, 320 W 15 Street, Indianapolis, IN, United States 46202.; Department of Radiology & Imaging Sciences, Indiana University School of Medicine, 550 University Blvd, Indianapolis, IN, United States 46202., Sasner M; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, United States, 04609., Lamb BT; Indiana University School of Medicine, 340 W 10 Street, Indianapolis, IN, United States 46202.; Stark Neurosciences Research Institute, 320 W 15 Street, Indianapolis, IN, United States 46202.; Department of Medical and Molecular Genetics, Indiana University School of Medicine, 410 W. 10 St., HITS 4000, Indianapolis, IN, United States 46202., Territo PR; Indiana University School of Medicine, 340 W 10 Street, Indianapolis, IN, United States 46202.; Stark Neurosciences Research Institute, 320 W 15 Street, Indianapolis, IN, United States 46202.; Department of Medicine, Division of Clinical Pharmacology, Indiana University School of Medicine, 545 Barnhill Drive, Indianapolis, IN, United States 46202., Sukoff Rizzo SJ; Department of Medicine, University of Pittsburgh Aging Institute, University of Pittsburgh School of Medicine, 100 Technology Drive, Pittsburgh, PA Pittsburgh, PA, United States 15219., Carter GW; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, United States, 04609.; The Jackson Laboratory for Genomic Medicine, 10 Discovery Drive, Farmington, CT, United States 06032.; Tufts University Graduate School of Biomedical Sciences, 136 Harrison Ave #813, Boston, MA, United States 02111.; Graduate School of Biomedical Sciences and Engineering, University of Maine, 5775 Stodder Hall, Orono, Maine, United States 04469., Howell GR; The Jackson Laboratory, 600 Main Street, Bar Harbor, ME, United States, 04609.; Tufts University Graduate School of Biomedical Sciences, 136 Harrison Ave #813, Boston, MA, United States 02111.; Graduate School of Biomedical Sciences and Engineering, University of Maine, 5775 Stodder Hall, Orono, Maine, United States 04469., Oblak AL; Indiana University School of Medicine, 340 W 10 Street, Indianapolis, IN, United States 46202.; Stark Neurosciences Research Institute, 320 W 15 Street, Indianapolis, IN, United States 46202.; Department of Radiology & Imaging Sciences, Indiana University School of Medicine, 550 University Blvd, Indianapolis, IN, United States 46202.

Publikováno v: BioRxiv : the preprint server for biology [bioRxiv] 2023 Dec 20. Date of Electronic Publication: 2023 Dec 20.