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Safety and Efficacy of a Novel Combination Cream (GN-037) in Healthy Volunteers and Patients with Plaque Psoriasis: A Phase 1 Trial

Autor: Zafer Sezer, Ahmet Inal, Salih L. Cinar, Mustafa M. Mazicioglu, Sedat Altug, Hatice Y. Karasulu, Mine Diril, Ayca Mehmetoglu Al, Serhat Kozlu, Nadir Ulu

Publikováno v: Dermatology and Therapy, Vol 13, Iss 7, Pp 1489-1501 (2023)

Abstract Introduction Psoriasis is a common skin disorder associated with physical and psychological burdens. Visible disfiguration can trigger a negative reaction which can cause much of the readily measurable psychological burden of the disease. Al

Externí odkaz: https://doaj.org/article/41bdd18396974527b07eca181385ce13

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Enhancing Oral Bioavailability of Domperidone Maleate: Formulation, In-Vitro Permeability Evaluation, In-Caco-2 cell Monolayers and In-Situ Rat Intestinal Permeability Studies

Autor: Mustafa Sinan Kaynak, Neslihan Üstündağ Okur, Emre Şefik Çağlar, Mine Diril, Saniye Özcan, Hatice Yeşim Karasulu

Publikováno v: Current Drug Delivery. 20

Background: The domperidone maleate, a lipophilic agent classified as a Biopharmaceutical Classification System Class II substance with weak water solubility. Self- Emulsifying Drug Delivery System is a novel approach to improve water solubility and,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::df813b9970d86cfab15159b44b60d568
https://doi.org/10.2174/1567201820666230214091509

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Formulation and In Vitro Evaluation of Self Microemulsifying Drug Delivery System Containing Atorvastatin Calcium

Autor: Mine Diril, Gülbeyaz Yildiz Türkyilmaz, H. Yeşim Karasulu

Publikováno v: Current Drug Delivery. 16:768-779

tArkyAlmaz, gAlbeyaz yAldAz/0000-0002-8601-0263; KARASULU, HATICE YESIM/0000-0002-1860-8255
WOS: 000493982000008
PubMed: 31429689
Objective: the aim of this study was to develop a new dosage form as an alternative to the classical tabl

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::945d2458f1ae05ef3a6d8595e82d64d8
https://doi.org/10.2174/1567201816666190820143957

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Development and Permeability Testing of Self-Emulsifying Atorvastatin Calcium Pellets and Tablets of Compressed Pellets

Autor: Miltiadis Toskas, Yesim Karasulu, Ioannis Nikolakakis, Mine Diril

Publikováno v: Processes
Volume 7
Issue 6
Processes, Vol 7, Iss 6, p 365 (2019)

WOS: 000475306200049
Self-emulsifying pellets (SEPs) of Atorvastatin Calcium (AtrCa) were developed and processed into tablets (SETs). Self-emulsifying drug delivery system (SEDDS) composed of oleic acid, Tween 20, Span 80 and N-Methyl-2-pyrolid

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cb7763e353535ac71a54e208e0b76782
https://doi.org/10.3390/pr7060365

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