Zobrazeno 1 - 10
of 27
pro vyhledávání: '"Mine, Koprulu"'
Autor:
Karl Smith-Byrne, Åsa Hedman, Marios Dimitriou, Trishna Desai, Alexandr V. Sokolov, Helgi B. Schioth, Mine Koprulu, Maik Pietzner, Claudia Langenberg, Joshua Atkins, Ricardo Cortez Penha, James McKay, Paul Brennan, Sirui Zhou, Brent J. Richards, James Yarmolinsky, Richard M. Martin, Joana Borlido, Xinmeng J. Mu, Adam Butterworth, Xia Shen, Jim Wilson, Themistocles L. Assimes, Rayjean J. Hung, Christopher Amos, Mark Purdue, Nathaniel Rothman, Stephen Chanock, Ruth C. Travis, Mattias Johansson, Anders Mälarstig
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-11 (2024)
Abstract Circulating proteins can reveal key pathways to cancer and identify therapeutic targets for cancer prevention. We investigate 2,074 circulating proteins and risk of nine common cancers (bladder, breast, endometrium, head and neck, lung, ovar
Externí odkaz:
https://doaj.org/article/96e36c04c03a43d3adbee6ea9c8410f5
Autor:
Trishna A. Desai, Åsa K. Hedman, Marios Dimitriou, Mine Koprulu, Sandy Figiel, Wencheng Yin, Mattias Johansson, Eleanor L. Watts, Joshua R. Atkins, Aleksandr V. Sokolov, Helgi B. Schiöth, Marc J. Gunter, Konstantinos K. Tsilidis, Richard M. Martin, Maik Pietzner, Claudia Langenberg, Ian G. Mills, Alastair D. Lamb, Anders Mälarstig, Tim J. Key, Ruth C. Travis, Karl Smith-Byrne
Publikováno v:
EBioMedicine, Vol 105, Iss , Pp 105168- (2024)
Summary: Background: Understanding the role of circulating proteins in prostate cancer risk can reveal key biological pathways and identify novel targets for cancer prevention. Methods: We investigated the association of 2002 genetically predicted ci
Externí odkaz:
https://doaj.org/article/1ace1755f8ce4d638c80b4c3f3d25968
Autor:
Maria Jesus Iglesias, Laura Sanchez-Rivera, Manal Ibrahim-Kosta, Clément Naudin, Gaëlle Munsch, Louisa Goumidi, Maria Farm, Philip M. Smith, Florian Thibord, Julia Barbara Kral-Pointner, Mun-Gwan Hong, Pierre Suchon, Marine Germain, Waltraud Schrottmaier, Philip Dusart, Anne Boland, David Kotol, Fredrik Edfors, Mine Koprulu, Maik Pietzner, Claudia Langenberg, Scott M. Damrauer, Andrew D. Johnson, Derek M. Klarin, Nicholas L. Smith, David M. Smadja, Margareta Holmström, Maria Magnusson, Angela Silveira, Mathias Uhlén, Thomas Renné, Angel Martinez-Perez, Joseph Emmerich, Jean-Francois Deleuze, Jovan Antovic, Jose Manuel Soria Fernandez, Alice Assinger, Jochen M. Schwenk, Joan Carles Souto Andres, Pierre-Emmanuel Morange, Lynn Marie Butler, David-Alexandre Trégouët, Jacob Odeberg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-23 (2023)
Abstract Venous thromboembolism (VTE) is a common, multi-causal disease with potentially serious short- and long-term complications. In clinical practice, there is a need for improved plasma biomarker-based tools for VTE diagnosis and risk prediction
Externí odkaz:
https://doaj.org/article/c60db97f387c490db06b926e375c503c
Autor:
Maria Jesus Iglesias, Laura Sanchez-Rivera, Manal Ibrahim-Kosta, Clément Naudin, Gaëlle Munsch, Louisa Goumidi, Maria Farm, Philip M. Smith, Florian Thibord, Julia Barbara Kral-Pointner, Mun-Gwan Hong, Pierre Suchon, Marine Germain, Waltraud Schrottmaier, Philip Dusart, Anne Boland, David Kotol, Fredrik Edfors, Mine Koprulu, Maik Pietzner, Claudia Langenberg, Scott M. Damrauer, Andrew D. Johnson, Derek M. Klarin, Nicholas L. Smith, David M. Smadja, Margareta Holmström, Maria Magnusson, Angela Silveira, Mathias Uhlén, Thomas Renné, Angel Martinez-Perez, Joseph Emmerich, Jean-Francois Deleuze, Jovan Antovic, Jose Manuel Soria Fernandez, Alice Assinger, Jochen M. Schwenk, Joan Carles Souto Andres, Pierre-Emmanuel Morange, Lynn Marie Butler, David-Alexandre Trégouët, Jacob Odeberg
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/10828cb1b6164088b38dcda63f634aab
Autor:
Maik Pietzner, Eleanor Wheeler, Julia Carrasco-Zanini, Nicola D. Kerrison, Erin Oerton, Mine Koprulu, Jian’an Luan, Aroon D. Hingorani, Steve A. Williams, Nicholas J. Wareham, Claudia Langenberg
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-13 (2021)
Broad-capture affinity-based proteomic technologies inform how the readout of our genes affects human health. Here, the authors integrate aptamer- and antibody-based profiling to understand the mechanisms underlying gene-protein-disease associations.
Externí odkaz:
https://doaj.org/article/ae9a1bfa769147d886496493f0292435
Autor:
Yajie Zhao, Stasa Stankovic, Mine Koprulu, Eleanor Wheeler, Felix R. Day, Hana Lango Allen, Nicola D. Kerrison, Maik Pietzner, Po-Ru Loh, Nicholas J. Wareham, Claudia Langenberg, Ken K. Ong, John R. B. Perry
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-6 (2021)
Mosaic loss of chromosome Y (LOY) is a common form of clonal mosaicism in leukocytes. Here, the authors extend genetic association analyses to rare variation using exome-sequence data from 82,277 males, finding that loss-of-function alleles in GIGYF1
Externí odkaz:
https://doaj.org/article/913fdc222dc74e48854e6709b1ef3e16
Autor:
Mine Koprulu, Julia Carrasco-Zanini, Eleanor Wheeler, Sam Lockhart, Nicola D. Kerrison, Nicholas J. Wareham, Maik Pietzner, Claudia Langenberg
Publikováno v:
Nature Metabolism. 5:516-528
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5279121862494c6f7748ea4eadb0fe00
https://doi.org/10.1038/s42255-023-00753-7
https://doi.org/10.1038/s42255-023-00753-7
Autor:
Maik Pietzner, Spiros Denaxas, Summaira Yasmeen, Maria Wörheide, Hannah E. Schmidt, Burulça Uluvar, Aakash Nepal, Mine Koprulu, Julia Carrasco-Zanini, Matthias Arnold, Annika Vogt, Gabi Kastenmüller, Harry Hemingway, Claudia Langenberg
Many diseases with significant health burden and healthcare costs have been neglected in biomedical research, partly due to a lack of data. Here, we systematically harmonized >12 million primary care and hospitalisation health records from ∼440,000
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4d2cb2ea0eeb0059a3243fc5158cfe56
https://doi.org/10.1101/2023.05.23.23290408
https://doi.org/10.1101/2023.05.23.23290408
Autor:
Karl Smith-Byrne, Åsa Hedman, Marios Dimitriou, Trishna Desai, Alexandr V. Sokolov, Helgi B. Schioth, Mine Koprulu, Maik Pietzner, Claudia Langenberg, Joshua Atkins, Ricardo Cortez, James McKay, Paul Brennan, Sirui Zhou, Brent J. Richards, James Yarmolinsky, Richard M. Martin, Joana Borlido, Xinmeng J. Mu, Adam Butterworth, Xia Shen, Jim Wilson, Themistocles L. Assimes, Rayjean J. Hung, Christopher Amos, Mark Purdue, Nathaniel Rothman, Stephen Chanock, Ruth C. Travis, Mattias Johansson, Anders Mälarstig
BackgroundUnderstanding the role of circulating proteins in cancer risk can reveal key biological pathways and identify novel therapeutic targets for cancer prevention.MethodsWe investigated the associations of 2,094 circulating proteins with risk of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4255abbd46adde24c7b60e7125176c5b
https://doi.org/10.1101/2023.05.05.23289547
https://doi.org/10.1101/2023.05.05.23289547
Autor:
Yajie Zhao, Eugene J. Gardner, Marcus A. Tuke, Huairen Zhang, Maik Pietzner, Mine Koprulu, Raina Y. Jia, Katherine S. Ruth, Andrew R. Wood, Robin N. Beaumont, Jessica Tyrrell, Samuel E. Jones, Hana Lango Allen, Felix R. Day, Claudia Langenberg, Timothy M. Frayling, Michael N. Weedon, John R.B. Perry, Ken K. Ong, Anna Murray
Purpose: The study aimed to systematically ascertain male sex chromosome abnormalities, 47,XXY (Klinefelter syndrome [KS]) and 47,XYY, and characterize their risks of adverse health outcomes. Methods: We analyzed genotyping array or exome sequence da
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7065b140c78e371f79fd84ac4f9835e7
https://www.repository.cam.ac.uk/handle/1810/338670
https://www.repository.cam.ac.uk/handle/1810/338670