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Akademický článek

Early life inter-kingdom interactions shape the immunological environment of the airways

Autor: Céline Pattaroni, Matthew Macowan, Roxanne Chatzis, Carmel Daunt, Adnan Custovic, Michael D. Shields, Ultan F. Power, Jonathan Grigg, Graham Roberts, Peter Ghazal, Jürgen Schwarze, Mindy Gore, Steve Turner, Andrew Bush, Sejal Saglani, Clare M. Lloyd, Benjamin J. Marsland

Publikováno v: Microbiome, Vol 10, Iss 1, Pp 1-16 (2022)

Abstract Background There is increasing evidence that the airway microbiome plays a key role in the establishment of respiratory health by interacting with the developing immune system early in life. While it has become clear that bacteria are involv

Externí odkaz: https://doaj.org/article/957ff96ae22e448bb648cd7b514a44f5

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Akademický článek

Comparative primary paediatric nasal epithelial cell culture differentiation and RSV-induced cytopathogenesis following culture in two commercial media.

Autor: Lindsay Broadbent, Sheerien Manzoor, Maria C Zarcone, Judit Barabas, Michael D Shields, Sejal Saglani, Claire M Lloyd, Andrew Bush, Adnan Custovic, Peter Ghazal, Mindy Gore, Ben Marsland, Graham Roberts, Jurgen Schwarze, Steve Turner, Ultan F Power

Publikováno v: PLoS ONE, Vol 15, Iss 3, p e0228229 (2020)

The culture of differentiated human airway epithelial cells allows the study of pathogen-host interactions and innate immune responses in a physiologically relevant in vitro model. As the use of primary cell culture has gained popularity the availabi

Externí odkaz: https://doaj.org/article/f1baaba14f33454cbce57d45e987e792

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Akademický článek

Pulmonary epithelial barrier and immunological functions at birth and in early life - key determinants of the development of asthma? A description of the protocol for the Breathing Together study [version 1; referees: 2 approved]

Autor: Steve Turner, Adnan Custovic, Peter Ghazal, Jonathan Grigg, Mindy Gore, John Henderson, Clare M. Lloyd, Ben Marsland, Ultan F. Power, Graham Roberts, Sejal Saglani, Jurgen Schwarze, Michael Shields, Andrew Bush

Publikováno v: Wellcome Open Research, Vol 3 (2018)

Background. Childhood asthma is a common complex condition whose aetiology is thought to involve gene-environment interactions in early life occurring at the airway epithelium, associated with immune dysmaturation. It is not clear if abnormal airway

Externí odkaz: https://doaj.org/article/92b7e2b152a647ab8b7d0eae4040ba8d

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The Epstein-Barr Virus Glycoprotein BDLF2 Is Essential for Efficient Viral Spread in Stratified Epithelium

Autor: Joshua J. Walston, Ian R. Hayman, Mindy Gore, Mary Ferguson, Rachel M. Temple, Jason Liao, Samina Alam, Craig Meyers, Sharof M. Tugizov, Lindsey Hutt-Fletcher, Clare E. Sample

Publikováno v: Journal of Virology. 97

The ubiquitous herpesvirus Epstein-Barr virus (EBV) is associated with cancers of B lymphocytes and epithelial cells and is primarily transmitted in saliva. While several models exist for analyzing the life cycle of EBV in B lymphocytes, models of EB

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::28bf641e1a2230195a52bc3707f62420
https://doi.org/10.1128/jvi.01528-22

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Early life inter-kingdom interactions shape the immunological environment of the airways

Publikováno v: Pattaroni, C, Macowan, M, Chatzis, R, Custovic, A, Shields, M D, Power, U F, Grigg, J, Roberts, G, Ghazal, P, Schwarze, J, Gore, M, Turner, S, Bush, A, Saglani, S, Lloyd, C M & Marsland, B 2022, ' Early life inter-kingdom interactions shape the immunological environment of the airways ', Microbiome, vol. 10, 34 . https://doi.org/10.1186/s40168-021-01201-y
Pattaroni, C, Macowan, M, Chatzis, R, Daunt, C, Custovic, A, Shields, M, Power, U F, Grigg, J, Roberts, G, Ghazal, P, Schwarze, J, Gore, M, Turner, S, Bush, A, Saglani, S, Lloyd, C M & Marsland, B J 2022, ' Early life inter-kingdom interactions shape the immunological environment of the airways ', Microbiome . https://doi.org/10.1186/s40168-021-01201-y

Background There is increasing evidence that the airway microbiome plays a key role in the establishment of respiratory health by interacting with the developing immune system early in life. While it has become clear that bacteria are involved in thi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1870a4140586b7f3f3d45cde39dba1da
http://hdl.handle.net/10044/1/93911

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Comparative primary paediatric nasal epithelial cell culture differentiation and RSV-induced cytopathogenesis following culture in two commercial media

Autor: Adnan Custovic, Graham Roberts, Sheerien Manzoor, Ultan F. Power, Judit Barabas, Jürgen Schwarze, Claire M. Lloyd, Ben Marsland, Steve Turner, Maria C. Zarcone, Sejal Saglani, Andrew Bush, Peter Ghazal, Lindsay Broadbent, Michael D. Shields, Mindy Gore

Publikováno v: Broadbent, L, Manzoor, S, Zarcone, M C, Barabas, J, Shields, M, Saglani, S, Lloyde, C M, Bush, A, Custovic, A, Ghazal, P, Gore, M, Marsland, B, Roberts, G, Schwarze, J, Turner, S & Power, U 2020, ' Comparative primary paediatric nasal epithelial cell culture differentiation and RSV-induced cytopathogenesis following culture in two commercial media. ', PLoS One . https://doi.org/10.1371/journal.pone.0228229
PLoS ONE, Vol 15, Iss 3, p e0228229 (2020)
Broadbent, L, Manzoor, S, Zarcone, M C, Barabas, J, Shields, M D, Saglani, S, Lloyd, C M, Bush, A, Custovic, A, Ghazal, P, Gore, M, Marsland, B, Roberts, G, Schwarze, J, Turner, S, Power, U F & Tripp, R A 2020, ' Comparative primary paediatric nasal epithelial cell culture differentiation and RSV-induced cytopathogenesis following culture in two commercial media ', PLoS ONE, vol. 15, no. 3, pp. e0228229 . https://doi.org/10.1371/journal.pone.0228229
PLoS ONE

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75702e7cdec4ebd81355be4c066ec9e1
https://pure.qub.ac.uk/en/publications/97e48ce3-4674-44fa-a942-41583d873b43

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Epstein–Barr virus glycoprotein gM can interact with the cellular protein p32 and knockdown of p32 impairs virus

Autor: Harish Changotra, Lindsey M. Hutt-Fletcher, Martin I. Muggeridge, Mindy Gore, Antonio Artigues, Susan M. Turk, Nagendra Thakur

Publikováno v: Virology. 489:223-232

The Epstein–Barr virus glycoprotein complex gMgN has been implicated in assembly and release of fully enveloped virus, although the precise role that it plays has not been elucidated. We report here that the long predicted cytoplasmic tail of gM is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::aa6752cb9923c0f89781061454349c79

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Pulmonary epithelial barrier and immunological functions at birth and in early life - key determinants of the development of asthma? A description of the protocol for the Breathing Together study

Autor: Jonathan Grigg, Clare M. Lloyd, Ultan F. Power, Jürgen Schwarze, Mindy Gore, Ben Marsland, Steve Turner, Peter Ghazal, Andrew Bush, Michael D. Shields, Sejal Saglani, Adnan Custovic, Graham Roberts, John Henderson

Publikováno v: Turner, S, Custovic, A, Ghazal, P, Grigg, J, Gore, M, Henderson, J, Lloyd, C M, Marsland, B, Power, U F, Roberts, G, Saglani, S, Schwarze, J, Shields, M & Bush, A 2018, ' Pulmonary epithelial barrier and immunological functions at birth and in early life-key determinants of the development of asthma? A description of the protocol for the Breathing Together study ', Wellcome open research, vol. 3, pp. 60 . https://doi.org/10.12688/wellcomeopenres.14489.1
Wellcome Open Research
Turner, S, Custovic, A, Ghazal, P, Grigg, J, Gore, M, Henderson, J, Lloyd, C M, Marsland, B, Power, U F, Roberts, G, Saglani, S, Schwarze, J, Shields, M & Bush, A 2018, ' Pulmonary epithelial barrier and immunological functions at birth and in early life-key determinants of the development of asthma? A description of the protocol for the Breathing Together study ', Wellcome Open Research, vol. 3, pp. 60 . https://doi.org/10.12688/wellcomeopenres.14489.1
Turner, S, Custovic, A, Grigg, J, Henderson, J, Lloyd, C & Marsland, B 2018, ' Pulmonary epithelial barrier and immunological functions at birth and in early life-key determinants of the development of asthma? A description of the protocol for the Breathing Together study ', Wellcome Open Research, vol. 3, 60 . https://doi.org/10.12688/wellcomeopenres.14489.1

Background. Childhood asthma is a common complex condition whoseaetiology is thought to involve gene-environment interactions in early lifeoccurring at the airway epithelium, associated with immune dysmaturation. It isnot clear if abnormal airway epi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::585d5037f0b6712c5c28db2838943eda
https://pure.qub.ac.uk/en/publications/7aa1c62c-0c84-496f-92e6-9e4a7c18e8d4

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Hepatitis B testing and treatment in HIV patients in The Gambia-Compliance with international guidelines and clinical outcomes

Autor: Gibril Ndow, Mindy Gore, Coumba Toure-Kane, Fouzia Sadiq, Yusuke Shimakawa, Maud Lemoine, Amina Sow, Saydiba Tamba, Saihou Sabally, Ramou Njie, Mark Thursz, Abdoulie Jatta, Penda Suso

Publikováno v: PLoS ONE
PLoS ONE, Public Library of Science, 2017, 12 (6), pp.e0179025. ⟨10.1371/journal.pone.0179025⟩
PLoS ONE, Vol 12, Iss 6, p e0179025 (2017)
PLoS ONE, 2017, 12 (6), pp.e0179025. ⟨10.1371/journal.pone.0179025⟩

International audience; BACKGROUND: Compliance with WHO guidelines on HBV screening and treatment in HIV-coinfected patients is often challenging in resource limited countries and has been poorly assessed in sub-Saharan Africa.; METHODS: Between 2015

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0d51e04324e4fb8d97cb2f4c11a7ee7c
https://hal-pasteur.archives-ouvertes.fr/pasteur-01570239/file/journal.pone.0179025.pdf

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