Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Mindy Chao"'
Autor:
William A. Denny, Gordon W. Rewcastle, Raphaël Frédérick, Peter R. Shepherd, Andrew J. Marshall, Kit Yee Tsang, Maruta Boyd, Mindy Chao, Christina M. Buchanan, Anna C. Giddens, Bruce C. Baguley, Claire Chaussade, Woo-Jeong Lee, Claire L. Lill, Shuqiao Yu, Jack U. Flanagan, Sharada Kolekar, Jackie D. Kendall, Alisha Malik
Publikováno v:
MedChemComm, Vol. 5, no.1, p. 41 [1-6] (2014)
As part of our investigation into the pyrazolo[1,5-a]pyridines as novel PI3K inhibitors, we report a range of analogues where the central linker portion of the molecule was varied while retaining the pyrazolo[1,5-a] pyridine and arylsulfonyl or arylc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7efef4b8d2678ce5198f3be7180cf30
https://doi.org/10.1039/c3md00221g
https://doi.org/10.1039/c3md00221g
Autor:
Shuqiao Yu, Elaine S. Marshall, Gordon W. Rewcastle, Christina M. Buchanan, Kit Yee Tsang, Stephen M. F. Jamieson, Peter R. Shepherd, William A. Denny, Woo-Jeong Lee, Claire L. Lill, Anna C. Giddens, Alisha Malik, Mindy Chao, Bruce C. Baguley, Jackie D. Kendall, Claire Chaussade, Sharada Kolekar
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(2)
As part of our investigation into pyrazolo[1,5-a]pyridines as novel p110α selective PI3 kinase inhibitors, we report a range of analogues with improved aqueous solubility by the addition of a basic amine. The compounds demonstrated comparable p110α
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ed1765decdddb96900a7fd603a3fd159
https://pubmed.ncbi.nlm.nih.gov/27923617
https://pubmed.ncbi.nlm.nih.gov/27923617
Autor:
Anna C. Giddens, Gordon W. Rewcastle, Peter R. Shepherd, Elaine S. Marshall, William A. Denny, Kit Yee Tsang, Shuqiao Yu, Alisha Malik, Raphaël Frédérick, Mindy Chao, Jack U. Flanagan, Ripudaman Singh, Bruce C. Baguley, Sharada Kolekar, Jackie D. Kendall, Claire Chaussade, Woo-Jeong Lee, Claire L. Lill, Stephen M. F. Jamieson, Christina M. Buchanan
Publikováno v:
Bioorganic & Medicinal Chemistry. 20:58-68
Structure-activity relationship studies of the pyrazolo[1,5-a]pyridine class of PI3 kinase inhibitors show that substitution off the hydrazone nitrogen and replacement of the sulfonyl both gave a loss of p110α selectivity, with the exception of an N
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::62b37468a52699793d2442ac9302f5c1
https://doi.org/10.1016/j.bmc.2011.11.031
https://doi.org/10.1016/j.bmc.2011.11.031
Autor:
Claire L. Lill, William A. Denny, Andrew J. Marshall, Woo-Jeong Lee, Elaine S. Marshall, Peter R. Shepherd, Gordon W. Rewcastle, Sharada Kolekar, Jack U. Flanagan, Mindy Chao, Bruce C. Baguley
Publikováno v:
Bioorganicmedicinal chemistry. 23(13)
A novel series of TGX-221 analogues was prepared and tested for their potency against the p110α, p110β, and p110δ isoforms of the PI3K enzyme, and in two cellular assays. The biological results were interpreted in terms of a p110β comparative mod
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2dbe4444c98d159583d16098a5fe4dd3
https://pubmed.ncbi.nlm.nih.gov/25890698
https://pubmed.ncbi.nlm.nih.gov/25890698
Autor:
Jackie D. Kendall, Mindy Chao, Christina M. Buchanan, Bruce C. Baguley, Ripudaman Singh, Philip Kestell, Gordon W. Rewcastle, Woo-Jeong Lee, William A. Denny, Claire L. Lill, Swarna A. Gamage, Stephen M. F. Jamieson, Peter R. Shepherd, Alisha Malik, Sharada Kolekar, Jack U. Flanagan
Publikováno v:
European journal of medicinal chemistry. 64
A range of 4-substituted derivatives of the pan class I PI 3-kinase inhibitor 2-(difluoromethyl)-1-[4,6-di-(4-morpholinyl)-1,3,5-triazin-2-yl]-1H-benzimidazole (ZSTK474) were prepared in a search for more soluble analogs. 4-Aminoalkoxy substituents p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7ab52ea282a82ee81c544f74fc65fda4
https://pubmed.ncbi.nlm.nih.gov/23644197
https://pubmed.ncbi.nlm.nih.gov/23644197
Autor:
Shuqiao Yu, Elaine S. Marshall, Mindy Chao, Jackie D. Kendall, William A. Denny, Bruce C. Baguley, Jack U. Flanagan, Gordon W. Rewcastle, Claire Chaussade, Claire L. Lill, Stephen M. F. Jamieson, Alisha Malik, Peter R. Shepherd, Woo-Jeong Lee, Raphaël Frédérick, Andrew J. Marshall, Christina M. Buchanan, Patrick D. O'Connor, Sharada Kolekar
Publikováno v:
Bioorganicmedicinal chemistry. 20(1)
We have made a novel series of pyrazolo[1,5-a]pyridines as PI3 kinase inhibitors, and demonstrated their selectivity for the p110α isoform over the other Class Ia PI3 kinases. We investigated the SAR around the pyrazolo[1,5-a]pyridine ring system, a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ba1310b502c1beee2f15e875eb14f52
https://pubmed.ncbi.nlm.nih.gov/22177405
https://pubmed.ncbi.nlm.nih.gov/22177405