Zobrazeno 1 - 9 of 9 pro vyhledávání: '"Mindy B. Forst"'
2
Small-Volume Continuous Manufacturing of Merestinib. Part 2. Technology Transfer and cGMP Manufacturing
Autor: Richard D. Miller, Kevin P. Cole, Timothy M. Braden, Todd D. Maloney, Bradley M. Campbell, Moussa Boukerche, Christopher K. Lippelt, Brandon J. Reizman, David Mitchell, Derek R. Starkey, Richard F. Cope, Sam Tadayon, Xin Zhang, Ping Huang, Mindy B. Forst, Michael E. Laurila, Molly Hess, Jonas Y. Buser, Jing Chen, Martin Kwok, Baoquan Sun, Martin D. Johnson, Justin L. Burt, Carla V. Luciani
Publikováno v: Organic Process Research & Development. 23:870-881
Technology transfer of a small volume continuous (SVC) process and Current Good Manufacturing Practices (cGMP) manufacturing of merestinib are described. A hybrid batch-SVC campaign was completed at a contract manufacturing organization under cGMP. T
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::bbd431b28c4c7db03a4cd9996f224085
https://doi.org/10.1021/acs.oprd.8b00442
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3
Small-Volume Continuous Manufacturing of Merestinib. Part 1. Process Development and Demonstration
Autor: Mindy B. Forst, Edward W. Conder, Brandon J. Reizman, Timothy M. Braden, Justin L. Burt, Christopher S. Polster, Molly Hess, Kevin P. Cole, Bradley M. Campbell, David Mitchell, Richard F. Cope, Michael E. Laurila, Moussa Boukerche, Martin D. Johnson, Aurpon W. Mitra, Michael R. Heller, Richard D. Miller, Jennifer McClary Groh, Joseph L. Phillips, John R. Howell, Todd D. Maloney
Publikováno v: Organic Process Research & Development. 23:858-869
Development of a small volume continuous process that used a combination of batch and flow unit operations to manufacture the small molecule oncolytic candidate merestinib is described. Continuous processing was enabled following the identification a
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::aaef0d8d2753aa1c2899452eb9cc8bfd
https://doi.org/10.1021/acs.oprd.8b00441
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4
An Automated Intermittent Flow Approach to Continuous Suzuki Coupling
Autor: Mindy B. Forst, Bradley M. Campbell, Richard D. Miller, David Mitchell, Martin D. Johnson, Molly Hess, Morgan Rosemeyer, Jennifer McClary Groh, Christopher S. Polster, Kevin P. Cole, Brandon J. Reizman
Publikováno v: Organic Process Research & Development. 20:820-830
A fully automated fill/empty reactor system for liquid–liquid biphasic Suzuki couplings is described. The system was capable of charging reactant and catalyst solutions to a heated vessel, heating reagent solutions by flow heat exchanger on the way
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::36e4e60eb6c3f662f0f525603c29b799
https://doi.org/10.1021/acs.oprd.6b00030
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5
Practical Synthesis of Chiral 2-Morpholine: (4-Benzylmorpholin-2-(S)-yl)-(tetrahydropyran-4-yl)methanone Mesylate, a Useful Pharmaceutical Intermediate
Autor: Mark A. Pietz, Michael M. Murray, Michael E. Kopach, Thierry Giard, Thierry Defrance, Utpal K. Singh, Vincent Mancuso, Michel Vanmarsenille, Gregory A. Stephenson, William G. Trankle, Kobierski Michael Edward, Mindy B. Forst
Publikováno v: Organic Process Research & Development. 13:209-224
A commercial synthesis was developed for the production of (4-benzylmorpholin-2-(S)-yl)-(tetrahydropyran-4-yl)methanone mesylate, 1a, a key starting material for a phase 2, new investigational drug candidate at Eli Lilly and Company. The target compo
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::59ea8393476d33dcd3c13cfa6038449d
https://doi.org/10.1021/op800247w
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6
Design, Development, and Scale-Up of a Selective meso-Epoxide Desymmetrization Process
Autor: Moher Eric D, John Allan Rieck, Richard D. Miller, Tracy K. Ditsworth, David A. Hay, Sandra S. K. Borders, Mindy B. Forst, Richard C. Hoying, and Duane A. Pierson, Joseph A. Turpin, Varie David Lee, Ryan J. Linder, Jason S. Cronin, David D. Anderson, and Jacob R. Remacle, Molly D. Brady, Hoard David W, Paul N. Dodson, Christopher A. Beck
Publikováno v: Organic Process Research & Development. 11:546-559
A pilot-plant scale desymmetrization of the cyclic meso-epoxide 4b, using a chiral lithium amide prepared from symmetrical diamine 17, was designed and implemented to provide allylic alcohol 3b in high yield and greater than 99% ee. This chiral alcoh
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::f53e1e122ffede3fb8c73298de6793ee
https://doi.org/10.1021/op060225f
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7
Development and validation of non-aqueous capillary electrophoresis methods to analyze boronic esters and acids
Autor: Anne M. Warner, Mindy B. Forst
Publikováno v: Journal of pharmaceutical and biomedical analysis.
Boronic esters and acids are potential intermediates in the manufacture of many active pharmaceutical ingredients (API). Accurate quantitation of the intermediate is necessary to assure the stoichiometry of the reaction. The analysis of these compoun
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae97cfa13780bc4240a33eaccc1478bf
https://pubmed.ncbi.nlm.nih.gov/22386209
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