Quantification of γδ T cells and HLA-DR+ NK cells does not predict emergence of new contrast enhancing lesions in MS patients suspending natalizumab treatment.

Autor: Mindaugas Paužuolis, Torsten Eich, Joachim Burman

Publikováno v: PLoS ONE, Vol 12, Iss 6, p e0179095 (2017)

Natalizumab (NTZ) is a drug that has been widely used in the treatment of multiple sclerosis (MS). NTZ is very effective in suppressing inflammation, but if treatment is suspended many patients will experience relapses.To investigate if quantificatio

Externí odkaz: https://doaj.org/article/dc8d2e5b53e84d469105c2beeb4f5502

Helicobacter pylori shows tropism to gastric differentiated pit cells dependent on urea chemotaxis

Autor: Carmen Aguilar, Mindaugas Pauzuolis, Malvika Pompaiah, Ehsan Vafadarnejad, Panagiota Arampatzi, Mara Fischer, Dominik Narres, Mastura Neyazi, Özge Kayisoglu, Thomas Sell, Nils Blüthgen, Markus Morkel, Armin Wiegering, Christoph-Thomas Germer, Stefan Kircher, Andreas Rosenwald, Antoine-Emmanuel Saliba, Sina Bartfeld

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

The carcinogenic bacterium Helicobacter pylori infects gastric cells. Here, the authors show that H. pylori preferentially infects differentiated cells in the pit region of gastric units, and this relies on bacterial chemotaxis towards host cell-rele

Externí odkaz: https://doaj.org/article/ab0c3cf3ec204eddbd4e5450e1ff1a10

TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis

Autor: José A. Aguilar-Briseño, Vinit Upasani, Bram M. ter Ellen, Jill Moser, Mindaugas Pauzuolis, Mariana Ruiz-Silva, Sothy Heng, Denis Laurent, Rithy Choeung, Philippe Dussart, Tineke Cantaert, Jolanda M. Smit, Izabela A. Rodenhuis-Zybert

Publikováno v: Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)

The mechanisms underlying immunpathologies in dengue virus (DENV) infection are incompletely understood. Here, authors show that TLR2 recognizes DENV particles inducing cytokine expression and activating vascular endothelium cells in vitro, and that

Externí odkaz: https://doaj.org/article/85dea333a8ac4394b33be3faacbbdbda

TLR2 on blood monocytes senses dengue virus infection and its expression correlates with disease pathogenesis

Autor: Izabela A. Rodenhuis-Zybert, Vinit Upasani, Bram M. ter Ellen, Mariana Ruiz-Silva, Rithy Choeung, Jill Moser, Mindaugas Pauzuolis, Denis R. St. Laurent, Tineke Cantaert, Philippe Dussart, José Alberto Aguilar-Briseño, Sothy Heng, Jolanda M. Smit

Publikováno v: Nature Communications
Nature Communications, Nature Publishing Group, 2020, 11 (1), pp.3177. ⟨10.1038/s41467-020-16849-7⟩
Nature Communications, Vol 11, Iss 1, Pp 1-14 (2020)
Nature Communications, 11(1):3177. Nature Publishing Group

Vascular permeability and plasma leakage are immune-pathologies of severe dengue virus (DENV) infection, but the mechanisms underlying the exacerbated inflammation during DENV pathogenesis are unclear. Here, we demonstrate that TLR2, together with it

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::208ffd5bdf01936c1e26cb9d9b748d7d
https://hal-riip.archives-ouvertes.fr/pasteur-03221719

Heterologous arenavirus vector prime-boost overrules self-tolerance for efficient tumor-specific CD8 T cell attack

Autor: Ilena Vincenti, Sabine Hoepner, Alfred Zippelius, Ursula Berka, Stephanie Darbre, Magdalena A. Krzyzaniak, Stephan Günther, Nicole Kirchhammer, Carsten Magnus, Romy Kerber, Daniel D. Pinschewer, Weldy V. Bonilla, Josipa Raguz, Sarah Schmidt, Min Lu, Klaus Orlinger, Anna-Friederike Marx, Sandra M. Kallert, Mindaugas Pauzuolis, Doron Merkler

Publikováno v: Cell Reports Medicine
Cell Reports. Medicine, Vol. 2, No 3 (2021) P. 100209

Summary Therapeutic vaccination regimens inducing clinically effective tumor-specific CD8+ T lymphocyte (CTL) responses are an unmet medical need. We engineer two distantly related arenaviruses, Pichinde virus and lymphocytic choriomeningitis virus,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffba0b2642642f958411b10f650588b1
https://doi.org/10.1016/j.xcrm.2021.100209