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A new self-immolative colistin prodrug with dual targeting functionalities and reduced toxicity for the treatment of intracellular bacterial infections

Autor: Gengqi Liu, Di Lu, Shiyu Zhu, Minchao Hao, Xingyue Yang, Xiaojian Wang, Yumiao Zhang

Publikováno v: Journal of biomedical materials research. Part AREFERENCES. 110(9)

Colistin is a potent antibiotic but its severe side effects including nephrotoxicity and neurotoxicity are the roadblock for their wide use in clinics. To solve this problem, we synthesized a new prodrug, mannose-maltose-colistin conjugate, termed MM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6807eb471678f43ef70e39558698ce14
https://pubmed.ncbi.nlm.nih.gov/35593460

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