Loss of HD-PTP function results in lipodystrophy, defective cellular signaling and altered lipid homeostasis.

Autor: Schultz DF; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA.; Immunology Graduate Program, Mayo Clinic, Rochester, Minnesota 55905, USA.; Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA., Davies BA; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA., Payne JA; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA., Martin CP; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA., Minard AY; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USA., Childs BG; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA., Zhang C; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA., Jeganathan KB; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA., Sturmlechner I; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA.; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen 9713 AV, The Netherlands., White TA; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota 55905, USA., de Bruin A; Department of Pediatrics, University of Groningen, University Medical Center Groningen, Groningen 9713 AV, The Netherlands.; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht 3584 CL, The Netherlands., Harkema L; Department of Biomolecular Health Sciences, Faculty of Veterinary Medicine, Utrecht University, Utrecht 3584 CL, The Netherlands., Chen H; Department of Biostatistics, Division of Quantitative Sciences, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA., Davies MA; Department of Melanoma Medical Oncology, Division of Cancer Medicine, University of Texas MD Anderson Cancer Center, Houston, Texas 77030, USA., Jachim S; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA., LeBrasseur NK; Robert and Arlene Kogod Center on Aging, Mayo Clinic, Rochester, Minnesota 55905, USA., Piper RC; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, Iowa 52242, USA., Li H; Department of Molecular Pharmacology and Experimental Therapeutics, Mayo Clinic, Rochester, Minnesota 55905, USA., Baker DJ; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA.; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA., van Deursen J; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA.; Department of Pediatric and Adolescent Medicine, Mayo Clinic, Rochester, Minnesota 55905, USA., Billadeau DD; Department of Immunology, Mayo Clinic, Rochester, Minnesota 55905, USA., Katzmann DJ; Department of Biochemistry and Molecular Biology, Mayo Clinic, Rochester, Minnesota 55905, USA.

Publikováno v: Journal of cell science [J Cell Sci] 2024 Sep 15; Vol. 137 (18). Date of Electronic Publication: 2024 Sep 27.

ANTH domains within CALM, HIP1R, and Sla2 recognize ubiquitin internalization signals.

Autor: Pashkova N; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, United States., Gakhar L; Carver College of Medicine Protein Crystallography Core, University of Iowa, Iowa City, United States.; Department of Biochemistry and Molecular Biology, University of Iowa, Iowa City, United States., Yu L; Department of Biochemistry and Molecular Biology, University of Iowa, Iowa City, United States.; Carver College of Medicine NMR Core, University of Iowa, Iowa City, United States., Schnicker NJ; Carver College of Medicine Protein Crystallography Core, University of Iowa, Iowa City, United States., Minard AY; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, United States., Winistorfer S; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, United States., Johnson IE; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, United States., Piper RC; Department of Molecular Physiology and Biophysics, University of Iowa, Iowa City, United States.

Publikováno v: ELife [Elife] 2021 Nov 25; Vol. 10. Date of Electronic Publication: 2021 Nov 25.

A Genome-Wide Screen of Deletion Mutants in the Filamentous Saccharomyces cerevisiae Background Identifies Ergosterol as a Direct Trigger of Macrophage Pyroptosis.

Autor: Koselny K; Department of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA., Mutlu N; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA., Minard AY; Department of Molecular Physiology and Biophysics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Kumar A; Department of Molecular, Cellular and Developmental Biology, University of Michigan, Ann Arbor, Michigan, USA., Krysan DJ; Department of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA damian-krysan@uiowa.edu melanie-wellington@uiowa.edu.; Department of Microbiology and Immunology, University of Rochester Medical Center, Rochester, New York, USA.; Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.; Department of Microbiology/Immunology, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA., Wellington M; Department of Pediatrics, University of Rochester Medical Center, Rochester, New York, USA damian-krysan@uiowa.edu melanie-wellington@uiowa.edu.; Department of Pediatrics, Carver College of Medicine, University of Iowa, Iowa City, Iowa, USA.

Publikováno v: MBio [mBio] 2018 Jul 31; Vol. 9 (4). Date of Electronic Publication: 2018 Jul 31.

High dietary fat and sucrose results in an extensive and time-dependent deterioration in health of multiple physiological systems in mice.

Autor: Burchfield JG; From the Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales 2006, Australia.; Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and., Kebede MA; From the Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales 2006, Australia., Meoli CC; From the Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales 2006, Australia.; Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and., Stöckli J; From the Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales 2006, Australia.; Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and., Whitworth PT; Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and., Wright AL; Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and., Hoffman NJ; From the Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales 2006, Australia.; Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and., Minard AY; From the Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales 2006, Australia.; Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and., Ma X; Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and., Krycer JR; From the Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales 2006, Australia.; Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and., Nelson ME; From the Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales 2006, Australia., Tan SX; Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and., Yau B; From the Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales 2006, Australia., Thomas KC; From the Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales 2006, Australia.; Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and., Wee NKY; Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and., Khor EC; Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and., Enriquez RF; Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and., Vissel B; Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and., Biden TJ; Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and., Baldock PA; Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and., Hoehn KL; Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and., Cantley J; Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and., Cooney GJ; From the Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales 2006, Australia.; Charles Perkins Centre, Sydney Medical School, University of Sydney, Camperdown, New South Wales 2006, Australia., James DE; From the Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales 2006, Australia, david.james@sydney.edu.au.; Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and.; Charles Perkins Centre, Sydney Medical School, University of Sydney, Camperdown, New South Wales 2006, Australia., Fazakerley DJ; From the Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Camperdown, New South Wales 2006, Australia.; Garvan Institute of Medical Research, Darlinghurst, Sydney, New South Wales 2010, Australia, and.

Publikováno v: The Journal of biological chemistry [J Biol Chem] 2018 Apr 13; Vol. 293 (15), pp. 5731-5745. Date of Electronic Publication: 2018 Feb 13.

mTORC1 Is a Major Regulatory Node in the FGF21 Signaling Network in Adipocytes.

Autor: Minard AY; The Garvan Institute of Medical Research, Sydney, NSW 2010, Australia; Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia., Tan SX; Institute of Molecular and Cell Biology, Singapore 138673, Singapore., Yang P; Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia; School of Mathematics and Statistics, University of Sydney, Sydney, NSW 2006, Australia., Fazakerley DJ; Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia., Domanova W; Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia., Parker BL; Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia., Humphrey SJ; Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia., Jothi R; Systems Biology Section, Epigenetics & Stem Cell Laboratory, National Institute of Environmental Health Sciences, National Institutes of Health, Research Triangle Park, NC 27709, USA., Stöckli J; Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia., James DE; Charles Perkins Centre, School of Life and Environmental Sciences, University of Sydney, Sydney, NSW 2006, Australia; School of Medicine, University of Sydney, Sydney, NSW 2006, Australia. Electronic address: david.james@sydney.edu.au.

Publikováno v: Cell reports [Cell Rep] 2016 Sep 27; Vol. 17 (1), pp. 29-36.