Size-reduced DREADD derivatives for AAV-assisted multimodal chemogenetic control of neuronal activity and behavior.

Autor: Miyake T; Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyō-ku, Kyoto 606-8501, Japan. Electronic address: tmiyake@pharm.kyoto-u.ac.jp., Tanaka K; Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyō-ku, Kyoto 606-8501, Japan., Inoue Y; Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyō-ku, Kyoto 606-8501, Japan., Nagai Y; Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan., Nishimura R; Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyō-ku, Kyoto 606-8501, Japan., Seta T; Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyō-ku, Kyoto 606-8501, Japan., Nakagawa S; Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyō-ku, Kyoto 606-8501, Japan., Inoue KI; Systems Neuroscience Section, Center for the Evolutionary Origins of Human Behavior, Kyoto University, Inuyama 484-8506, Japan., Hasegawa E; Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyō-ku, Kyoto 606-8501, Japan., Minamimoto T; Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan., Doi M; Department of Systems Biology, Graduate School of Pharmaceutical Sciences, Kyoto University, Sakyō-ku, Kyoto 606-8501, Japan. Electronic address: doimasao@pharm.kyoto-u.ac.jp.

Publikováno v: Cell reports methods [Cell Rep Methods] 2024 Oct 21; Vol. 4 (10), pp. 100881.

Distinct roles of monkey OFC-subcortical pathways in adaptive behavior.

Autor: Oyama K; Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba, Japan.; PRESTO, Japan Science and Technology Agency, Kawaguchi, Japan., Majima K; PRESTO, Japan Science and Technology Agency, Kawaguchi, Japan.; Institute for Quantum Life Science, National Institutes for Quantum Science and Technology, Chiba, Japan., Nagai Y; Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba, Japan., Hori Y; Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba, Japan., Hirabayashi T; Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba, Japan., Eldridge MAG; Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA., Mimura K; Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba, Japan.; Research Center for Medical and Health Data Science, The Institute of Statistical Mathematics, Tachikawa, Japan., Miyakawa N; Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba, Japan., Fujimoto A; Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba, Japan., Hori Y; Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba, Japan., Iwaoki H; Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba, Japan., Inoue KI; Systems Neuroscience Section, Center for the Evolutionary Origins of Human Behavior, Kyoto University, Inuyama, Japan., Saunders RC; Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA., Takada M; Systems Neuroscience Section, Center for the Evolutionary Origins of Human Behavior, Kyoto University, Inuyama, Japan., Yahata N; Institute for Quantum Life Science, National Institutes for Quantum Science and Technology, Chiba, Japan., Higuchi M; Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba, Japan., Richmond BJ; Laboratory of Neuropsychology, National Institute of Mental Health, National Institutes of Health, Bethesda, MD, USA., Minamimoto T; Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba, Japan. minamimoto.takafumi@qst.go.jp.

Publikováno v: Nature communications [Nat Commun] 2024 Aug 28; Vol. 15 (1), pp. 6487. Date of Electronic Publication: 2024 Aug 28.

Imaging α-synuclein pathologies in animal models and patients with Parkinson's and related diseases.

Autor: Endo H; Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan. Electronic address: endo.hironobu@qst.go.jp., Ono M; Institute for Quantum Life Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan., Takado Y; Institute for Quantum Life Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan., Matsuoka K; Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan; Department of Psychiatry, Nara Medical University, Nara 634-8522, Japan., Takahashi M; Quantum Neuromapping and Neuromodulation Team, Institute for Quantum Life Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan., Tagai K; Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan; Department of Psychiatry, The Jikei University School of Medicine, Tokyo 105-8461, Japan., Kataoka Y; Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan., Hirata K; Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan; Department of Neurology and Neurological Science, Tokyo Medical and Dental University, Tokyo 113-8510, Japan., Takahata K; Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan; Department of Psychiatry, Keio University School of Medicine, Tokyo 160-0016, Japan., Seki C; Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan., Kokubo N; Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan., Fujinaga M; Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan., Mori W; Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan., Nagai Y; Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan., Mimura K; Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan; Research Center for Medical and Health Data Science, The Institute of Statistical Mathematics, Tokyo 190-8562, Japan., Kumata K; Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan., Kikuchi T; Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan., Shimozawa A; Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan., Mishra SK; Department of BioMolecular Sciences, The University of Mississippi, Oxford, MS 38677, USA., Yamaguchi Y; Division of Structural Glycobiology, Institute of Molecular Biomembrane and Glycobiology, Tohoku Medical and Pharmaceutical University, Sendai 981-8558, Miyagi Japan., Shimizu H; Department of Pathology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan., Kakita A; Department of Pathology, Brain Research Institute, Niigata University, Niigata 951-8585, Japan., Takuwa H; Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan; Quantum Neuromapping and Neuromodulation Team, Institute for Quantum Life Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan., Shinotoh H; Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan; Neurology Clinic, Chiba 260-0045, Chiba Japan., Shimada H; Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan; Department of Functional Neurology & Neurosurgery, Center for Integrated Human Brain Science, Brain Research Institute, Niigata University, Niigata 951-8585, Japan., Kimura Y; Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan; Department of Clinical and Experimental Neuroimaging, Center for Development of Advanced Medicine for Dementia, National Center for Geriatrics and Gerontology, Obu 474-8511, Aichi, Japan., Ichise M; Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan., Suhara T; National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan., Minamimoto T; Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan., Sahara N; Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan., Kawamura K; Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan., Zhang MR; Department of Advanced Nuclear Medicine Sciences, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan., Hasegawa M; Department of Dementia and Higher Brain Function, Tokyo Metropolitan Institute of Medical Science, Tokyo 156-8506, Japan., Higuchi M; Advanced Neuroimaging Center, Institute for Quantum Medical Science, National Institutes for Quantum Science and Technology, Chiba 263-8555, Japan; Department of Neuroetiology and Diagnostic Science, Osaka Metropolitan University Graduate School of Medicine, Osaka 545-8585, Japan.

Publikováno v: Neuron [Neuron] 2024 Aug 07; Vol. 112 (15), pp. 2540-2557.e8. Date of Electronic Publication: 2024 Jun 05.

Imaging-based chemogenetics for dissecting neural circuits in nonhuman primates.

Autor: Minamimoto T; Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba, Japan., Nagai Y; Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba, Japan., Oyama K; Advanced Neuroimaging Center, National Institutes for Quantum Science and Technology, Chiba, Japan.

Publikováno v: Proceedings of the Japan Academy. Series B, Physical and biological sciences [Proc Jpn Acad Ser B Phys Biol Sci] 2024; Vol. 100 (8), pp. 476-489.

[Frontiers in the Development of Chemogenetic Therapies for the Treatment of Epilepsy].

Autor: Miyakawa N; National Institutes for Quantum Science and Technology., Minamimoto T

Publikováno v: Brain and nerve = Shinkei kenkyu no shinpo [Brain Nerve] 2024 Jan; Vol. 76 (1), pp. 73-79.