CDKN2A deletion remodels lipid metabolism to prime glioblastoma for ferroptosis

Autor: Minami, Jenna K., Morrow, Danielle, Bayley, Nicholas A., Fernandez, Elizabeth G., Salinas, Jennifer J., Tse, Christopher, Zhu, Henan, Su, Baolong, Plawat, Rhea, Jones, Anthony, Sammarco, Alessandro, Liau, Linda M., Graeber, Thomas G., Williams, Kevin J., Cloughesy, Timothy F., Dixon, Scott J., Bensinger, Steven J., Nathanson, David A.

Publikováno v: In Cancer Cell 12 June 2023 41(6):1048-1060

Plasticity of Extrachromosomal and Intrachromosomal BRAF Amplifications in Overcoming Targeted Therapy Dosage Challenges.

Autor: Song K; Department of Bioengineering, University of California, Los Angeles, California., Minami JK; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California.; Department of Integrative Biology and Physiology, David Geffen School of Medicine, University of California, Los Angeles, California., Huang A; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California., Dehkordi SR; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, California., Lomeli SH; Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California., Luebeck J; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, California., Goodman MH; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California., Moriceau G; Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California., Krijgsman O; Division of Molecular Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Dharanipragada P; Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California., Ridgley T; Bioinformatics Interdepartmental Program, University of California, Los Angeles, California., Crosson WP; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California., Salazar J; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California., Pazol E; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California., Karin G; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California., Jayaraman R; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California., Balanis NG; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California., Alhani S; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California., Sheu K; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California., Ten Hoeve J; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California.; University of California, Los Angeles, Metabolomics Center, Los Angeles, California., Palermo A; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California.; University of California, Los Angeles, Metabolomics Center, Los Angeles, California., Motika SE; Department of Chemistry, Institute for Genomic Biology, Cancer Center at Illinois, University of Illinois, Urbana-Champaign, Illinois., Senaratne TN; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California., Paraiso KH; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California., Hergenrother PJ; Department of Chemistry, Institute for Genomic Biology, Cancer Center at Illinois, University of Illinois, Urbana-Champaign, Illinois., Rao PN; Department of Pathology and Laboratory Medicine, David Geffen School of Medicine, University of California, Los Angeles, California., Multani AS; Department of Genetics, The University of Texas MD Anderson Cancer Center, Houston, Texas., Peeper DS; Division of Molecular Oncology, The Netherlands Cancer Institute, Amsterdam, the Netherlands., Bafna V; Department of Computer Science and Engineering, University of California, San Diego, La Jolla, California., Lo RS; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California.; Division of Dermatology, Department of Medicine, David Geffen School of Medicine, University of California, Los Angeles, California.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California., Graeber TG; Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, California.; University of California, Los Angeles, Metabolomics Center, Los Angeles, California.; Jonsson Comprehensive Cancer Center, University of California, Los Angeles, California.; Crump Institute for Molecular Imaging, University of California, Los Angeles, California.; California NanoSystems Institute, University of California, Los Angeles, California.; Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California, Los Angeles, California.

Publikováno v: Cancer discovery [Cancer Discov] 2022 Apr 01; Vol. 12 (4), pp. 1046-1069.