A Hepatic GAbp-AMPK Axis Links Inflammatory Signaling to Systemic Vascular Damage

Autor: Katharina Niopek, Bilgen Ekim Üstünel, Susanne Seitz, Minako Sakurai, Annika Zota, Frits Mattijssen, Xiaoyue Wang, Tjeerd Sijmonsma, Yvonne Feuchter, Anna M. Gail, Barbara Leuchs, Dominik Niopek, Oskar Staufer, Maik Brune, Carsten Sticht, Norbert Gretz, Karin Müller-Decker, Hans-Peter Hammes, Peter Nawroth, Thomas Fleming, Michael D. Conkright, Matthias Blüher, Anja Zeigerer, Stephan Herzig, Mauricio Berriel Diaz

Publikováno v: Cell Reports, Vol 20, Iss 6, Pp 1422-1434 (2017)

Increased pro-inflammatory signaling is a hallmark of metabolic dysfunction in obesity and diabetes. Although both inflammatory and energy substrate handling processes represent critical layers of metabolic control, their molecular integration sites

Externí odkaz: https://doaj.org/article/2202dbc7845d40ae91de1eae8c20361a

TSC22D4 promotes TGFβ1-induced activation of hepatic stellate cells

Autor: Minako Sakurai, Peter Weber, Gretchen Wolff, Annika Wieder, Julia Szendroedi, Stephan Herzig, Bilgen Ekim Üstünel

Publikováno v: Biochemical and Biophysical Research Communications. 618:46-53

Non-alcoholic fatty liver disease (NAFLD), non-alcoholic steatohepatitis (NASH) and liver fibrosis emerge as progressive liver diseases that accompany metabolic syndrome usually characterized by obesity, insulin resistance and type 2 diabetes. Curren

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3aee00c08dd6f4d433a76145fac8e058
https://doi.org/10.1016/j.bbrc.2022.05.100

Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication

Autor: Annette Feuchtinger, Gretchen Wolff, Bilgen Ekim Üstünel, Minako Sakurai, Anne Loft, Felix B. Pedersen, Kan Kau Chow, Peter P. Nawroth, Maria Troullinaki, Mauricio Berriel Diaz, Søren Fisker Schmidt, Mike Krogh Terkelsen, Stephan Herzig, Michele Puglia, Ana Jimena Alfaro, Riccardo Berutti, Blagoy Blagoev, Kim Ravnskjaer, Adriano Maida

Publikováno v: Loft, A, Alfaro, A J, Schmidt, S F, Pedersen, F B, Terkelsen, M K, Puglia, M, Chow, K K, Feuchtinger, A, Troullinaki, M, Maida, A, Wolff, G, Sakurai, M, Berutti, R, Üstünel, B E, Nawroth, P, Ravnskjaer, K, Diaz, M B, Blagoev, B & Herzig, S 2021, ' Liver-fibrosis-activated transcriptional networks govern hepatocyte reprogramming and intra-hepatic communication ', Cell Metabolism, vol. 33, no. 8, pp. 1685-1700.e9 . https://doi.org/10.1016/j.cmet.2021.06.005
Cell Metab. 33, 1685-1700.e9 (2021)

Liver fibrosis is a strong predictor of long-term mortality in individuals with metabolic-associated fatty liver disease; yet, the mechanisms underlying the progression from the comparatively benign fatty liver state to advanced non-alcoholic steatoh

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7183305586faeb771006a5f0b783ca33
https://portal.findresearcher.sdu.dk/da/publications/059a9be0-74d1-4a91-9d8c-e040db75bd2a

OLFM4, LY6D and S100A7 as potent markers for distant metastasis in estrogen receptor‐positive breast carcinoma

Autor: Takanori Ishida, Takanori Watanabe, Kiyoshi Takagi, Ryuichi Yoshida, Hironobu Sasano, Hiroyoshi Suzuki, Takashi Suzuki, Minako Sakurai, Yasuhiro Miki, Yoshiaki Onodera, Kazuhiro Sakamoto, Ai Sato, Akifumi Mayama

Publikováno v: Cancer Science

Metastatic breast cancer is a highly lethal disease, and it is very important to evaluate the biomarkers associated with distant metastasis. However, molecular features of distant metastasis remain largely unknown in breast cancer. Estrogens play an

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::017a68bfbbf6290dc1e2a20785d6663a
http://europepmc.org/articles/PMC6172070

Interaction with adipocyte stromal cells induces breast cancer malignancy via S100A7 upregulation in breast cancer microenvironment

Autor: Noriaki Ohuchi, Takashi Suzuki, Takanori Ishida, Hironobu Sasano, Yasuhiro Miki, Kiyoshi Takagi, Minako Sakurai

Publikováno v: Breast Cancer Research, Vol 19, Iss 1, Pp 1-12 (2017)
Breast Cancer Research : BCR

Background Breast adipocytes play important roles in both the development and function of mammary epithelial cells. Therefore, carcinoma–adipose stromal cell (ASC) interactions have been considered pivotal in supporting tumor growth in breast cance

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12f2faf71c76a215fc8c2fd35b9c61ab
http://link.springer.com/article/10.1186/s13058-017-0863-0