Generation of functional ciliated cholangiocytes from human pluripotent stem cells

Autor: Mina Ogawa, Jia-Xin Jiang, Sunny Xia, Donghe Yang, Avrilynn Ding, Onofrio Laselva, Marcela Hernandez, Changyi Cui, Yuichiro Higuchi, Hiroshi Suemizu, Craig Dorrell, Markus Grompe, Christine E. Bear, Shinichiro Ogawa

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)

Current protocols to generate cholangiocytes from human pluripotent cells produce immature cells. Here the authors identify retinoic acid, BMP, cAMP and Rho kinase pathways as regulators of cholangiocyte maturation, and generate ciliated cholangiocyt

Externí odkaz: https://doaj.org/article/e2c37e554f8c4d829b4039f62abf625f

Archival bone marrow smears are useful in targeted next-generation sequencing for diagnosing myeloid neoplasms.

Autor: Daichi Sadato, Chizuko Hirama, Ai Kaiho-Soma, Ayaka Yamaguchi, Hiroko Kogure, Sonomi Takakuwa, Mina Ogawa, Noriko Doki, Kazuteru Ohashi, Hironori Harada, Keisuke Oboki, Yuka Harada

Publikováno v: PLoS ONE, Vol 16, Iss 7, p e0255257 (2021)

Gene abnormalities, including mutations and fusions, are important determinants in the molecular diagnosis of myeloid neoplasms. The use of bone marrow (BM) smears as a source of DNA and RNA for next-generation sequencing (NGS) enables molecular diag

Externí odkaz: https://doaj.org/article/3173f9b171914b53b197c507cbe2a672

Generation of functional ciliated cholangiocytes from human pluripotent stem cells

Autor: Jia-Xin Jiang, Sunny Xia, Markus Grompe, Christine E. Bear, Changyi Cui, Hiroshi Suemizu, Yuichiro Higuchi, Avrilynn Ding, Mina Ogawa, Onofrio Laselva, Shinichiro Ogawa, Craig Dorrell, Donghe Yang, Marcela Hernandez

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-19 (2021)
Nature Communications

The derivation of mature functional cholangiocytes from human pluripotent stem cells (hPSCs) provides a model for studying the pathogenesis of cholangiopathies and for developing therapies to treat them. Current differentiation protocols are not effi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f5e8129a6003dd9e383bac16b7091f05
https://doaj.org/article/e2c37e554f8c4d829b4039f62abf625f

Generation of functional ciliated cholangiocytes from human pluripotent stem cells

Autor: Gordon Keller, Markus Grompe, Mina Ogawa, Avrilynn Ding, Donghe Yang, Onofrio Laselva, Sunny Xia, Jia-Xin Jiang, Marcela Hernández, Changyi Cui, Shinichiro Ogawa, Stephanie Chin, Craig Dorrell, Christine E. Bear, Hiroshi Suemizu, Yuichiro Higuchi

The derivation of mature functional cholangiocytes from human pluripotent stem cells (hPSCs) would provide a model for studying the pathogenesis of cholangiopathies and for developing novel therapies to treat them. Current differentiation protocols a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::689c496c581662c557a3c66c40dc9097
https://doi.org/10.1101/2021.03.23.436530

Status of x-ray imaging and spectroscopy mission (XRISM)

Autor: Yutaka Fujita, Koji Mukai, Peter Shirron, Kumiko K. Nobukawa, Toshiaki Takeshima, Isamu Hatsukade, Richard F. Mushotzky, Brian J. Williams, Greg Brown, Hirofumi Noda, Brian Comber, Maria Diaz-Trigo, Manabu Ishida, Brian R. McNamara, Takahiro Sasaki, M. Ohno, Iurii Babyk, Richard L. Kelley, Sayuri Iga, Hiroshi Nakajima, Yuusuke Uchida, Hiroya Yamaguchi, Caroline A. Kilbourne, Takeshi Go Tsuru, Kosuke Sato, Tsunefumi Mizuno, Ryo Iizuka, Irina Zhuravleva, Shogo B. Kobayashi, Hironori Matsumoto, Matthew Holland, K. Matsuzaki, Makoto Sawada, Laura Brenneman, Susumu Yasuda, Shinya Yamada, Makoto Tashiro, Hirokazu Odaka, Yoshihiro Ueda, Keiichi Yanagase, Hiroki Akamatsu, Yasuharu Sugawara, Akihiro Furuzawa, Nobutaka Bando, Akio Hoshino, Koji Mori, Misaki Mizumoto, Lia Corrales, Katsuhiro Hayashi, Yasushi Fukazawa, Hideki Uchiyama, Hironori Maejima, Robert Petre, Yoshitaka Ishisaki, Teruaki Enoto, Mina Ogawa, Kenichi Toda, Natalie Hell, Shin'ichiro Uno, Tessei Yoshida, Thomas G. Bialas, Maurice A. Leutenegger, Masayuki Ohta, Yang Soong, Elisa Costantini, Kenji Hamaguchi, Shunji Kitamoto, Takafumi Horiuchi, Leslie Hartz, Luigi C. Gallo, Edmund Hodges-Kluck, Renata Cumbee, Yusuke Nishioka, Toshiki Sato, Paul P. Plucinsky, Katja Pottschmidt, Aya Kubota, Ehud Behar, Tom Lockard, Masanobu Ozaki, Kenji Minesugi, Ann Hornschemeier, T. R. Jaffe, Aurora Simionescu, Kazutaka Yamaoka, Stéphane Paltani, Keisuke Tamura, Chris Done, Makoto Yamauchi, Kouichi Hagino, Kosei Ishimura, Akihide Kobayashi, Eric J. Miller, Carlo Ferrigno, Hiromitsu Takahashi, Hiromi Seta, Nathalie Gorter, Cor P. de Vries, Michael J. Sampson, A. E. Szymkowiak, Mark O. Kimball, Gary A. Sneiderman, Dan McCammon, Meng P. Chiao, S. Eguchi, Randall K. Smith, Naoki Ishihama, Yohko Tsuboi, Jon M. Miller, Erin Kara, Takayoshi Kohmura, Timothy R. Kallman, Takashi Okajima, Kenichiro Nigo, Jan-Willem den Herder, Shigeo Yamauchi, Kazunori Someya, Maxim Markevitch, Yuto Ichinohe, M. C. Witthoeft, Yukikatsu Terada, Nasa Yoshioka, Edgar Canavan, Jelle Kaastra, Takao Kitaguchi, Masahiro Tsujimoto, Hideto Nakamura, Shinji Mitani, Hiroyuki Uchida, Masayoshi Nobukawa, R. Sato, Atsushi Tanimoto, Junko S. Hiraga, Keisuke Shinozaki, Yuichiro Ezoe, Hiroshi Tsunemi, Brian McLaughlin, Yasuko Shibano, Ikuyuki Mitsuishi, Matteo Guainazzi, Lillian Reichenthal, Yuichi Terashima, Kumi Ishikawa, Naomi Ota, Chikara Natsukari, Joseph Miko, Kiyoshi Hayashida, M. Loewenstein, Connor Martz, Tahir Yaqoob, D. Eckert, Ryuichi Fujimoto, Johannes Dercksen, Hiroshi Murakami, Hiroshi Tomida, Ken Ebisawa, Rob Wolfs, Martin Grim, Tomomi Watanabe, Marc Audard, Keisuke Sugawara, Yoh Takei, Megan E. Eckart, Takaya Ohashi, Atsushi Okamoto, Noriko Y. Yamasaki, Shin Watanabe, Yoshitomo Maeda, Shuhei Shigeto, Yoshitaka Arai, Maki Shida, Hisamitsu Awaki, Muzi Li, Takaaki Tanaka, Tadayasu Dotani, David Hawthorn, Jacco Vink, Joy Henegar-Leon, Rozenn Boissay-Malaquin, Kazuhiro Nakazawa, Aya Bamba, Megumi Shidatsu, Satoru Katsuda, Liyi Gu, Kyoko Matsushita, Toru Tamagawa, F. Scott Porter, Michael J. DiPirro, Steven Kenyon

Publikováno v: Space Telescopes and Instrumentation 2020 : Ultraviolet to Gamma Ray: 14-18 December 2020, online only, California, United States, 1

The X-Ray Imaging and Spectroscopy Mission (XRISM) is the successor to the 2016 Hitomi mission that ended prematurely. Like Hitomi, the primary science goals are to examine astrophysical problems with precise highresolution X-ray spectroscopy. XRISM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::584669694a480b163b59a24d5a15ac88
https://dare.uva.nl/personal/pure/en/publications/status-of-xray-imaging-and-spectroscopy-mission-xrism(68bf923f-f7e0-407f-b72e-012da2196903).html