Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mina O Seedhom"'
Autor:
Mina O Seedhom, Devin Dersh, Jaroslav Holly, Mariana Pavon-Eternod, Jiajie Wei, Matthew Angel, Lucas Shores, Alexandre David, Jefferson Santos, Heather Hickman, Jonathan W Yewdell
Publikováno v:
eLife, Vol 12 (2024)
Rapid lymphocyte cell division places enormous demands on the protein synthesis machinery. Flow cytometric measurement of puromycylated ribosome-associated nascent chains after treating cells or mice with translation initiation inhibitors reveals tha
Externí odkaz:
https://doaj.org/article/a897f0373fa04d45a5ac80087002cccd
Autor:
Jennifer E. Cowan, Justin Malin, Yongge Zhao, Mina O. Seedhom, Christelle Harly, Izumi Ohigashi, Michael Kelly, Yousuke Takahama, Jonathan W. Yewdell, Maggie Cam, Avinash Bhandoola
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Thymic epithelial cells (TEC) are essential for the maturation of functional T cells, while thymus size is proportional to the overall output efficiency. Here the authors show, using transcriptome analyses, that mouse fetal TEC maintain a Myc-depende
Externí odkaz:
https://doaj.org/article/784327815c984356aac217a9fbd2ed1e
Autor:
Jane Chuprin, Hannah Buettner, Mina O. Seedhom, Dale L. Greiner, James G. Keck, Fumihiko Ishikawa, Leonard D. Shultz, Michael A. Brehm
Publikováno v:
Nature Reviews Clinical Oncology. 20:192-206
Autor:
Mina O. Seedhom, Devin Dersh, Jaroslav Holly, Mariana Pavon-Eternod, Jiajie Wei, Matthew Angel, Lucas Shores, Alexandre David, Jefferson Santos, Heather D. Hickman, Jonathan W. Yewdell
Rapid lymphocyte cell division places enormous demands on the protein synthesis machinery. Flow cytometric measurement of puromycylated ribosome-associated nascent chains after treating cells or mice with translation initiation inhibitors reveals tha
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a75b17bf20d68718859e2f05879532d0
https://doi.org/10.1101/2022.10.31.514539
https://doi.org/10.1101/2022.10.31.514539
Autor:
James D. Phelan, Mina O. Seedhom, Rigel J. Kishton, Tovah E. Markowitz, Nicholas P. Restifo, Justin B. Lack, Jonathan W. Yewdell, Craig J. Thomas, George E. Wright, Jesse H. Arbuckle, Thomas M. Kristie, Boya Wang, Da-Wei Huang, Devin Dersh, Jaroslav Holly, Megan E. Gumina, Michele Ceribelli, Louis M. Staudt, Nathan Fridlyand
SummaryTumors frequently subvert MHC class I (MHC-I) peptide presentation to evade CD8+ T cell immunosurveillance. To better define the regulatory networks controlling antigen presentation, we employed genome-wide screening in human diffuse large B c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d770b191f5ac73f8604b65ee902b7d31
https://doi.org/10.1101/2020.03.13.989558
https://doi.org/10.1101/2020.03.13.989558
Autor:
Tovah E. Markowitz, Louis M. Staudt, Jonathan W. Yewdell, Boya Wang, Craig J. Thomas, George E. Wright, Justin B. Lack, Nathan Fridlyand, Nicholas P. Restifo, Da-Wei Huang, James D. Phelan, Mina O. Seedhom, Megan E. Gumina, Thomas M. Kristie, Rigel J. Kishton, Devin Dersh, Jaroslav Holly, Jesse H. Arbuckle, Michele Ceribelli
Publikováno v:
Immunity
Summary Tumors frequently subvert major histocompatibility complex class I (MHC-I) peptide presentation to evade CD8+ T cell immunosurveillance, though how this is accomplished is not always well defined. To identify the global regulatory networks co
Autor:
Jonathan W. Yewdell, Justin Malin, Izumi Ohigashi, Avinash Bhandoola, Yousuke Takahama, Yongge Zhao, Christelle Harly, Maggie Cam, Mina O. Seedhom, Michael C. Kelly, Jennifer E. Cowan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-14 (2019)
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.5498. ⟨10.1038/s41467-019-13465-y⟩
Nature Communications
Nature Communications, Nature Publishing Group, 2019, 10 (1), pp.5498. ⟨10.1038/s41467-019-13465-y⟩
Interactions between thymic epithelial cells (TEC) and developing thymocytes are essential for T cell development, but molecular insights on TEC and thymus homeostasis are still lacking. Here we identify distinct transcriptional programs of TEC that
Autor:
Margery G. Smelkinson, Jiajie Wei, Ning Yang, Kazuyo Takeda, Devin Dersh, Damien Zanker, Weisan Chen, Ajit Jadhav, James S. Gibbs, Jonathan W. Yewdell, Mina O. Seedhom, Anthony R. Di Carluccio
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 198(10)
CD8+ T cell immunosurveillance is based on recognizing oligopeptides presented by MHC class I molecules. Despite decades of study, the importance of protein ubiquitylation to peptide generation remains uncertain. In this study, we examined the abilit
We describe the in vivo ribopuromycylation (RPM) method, which uses a puromycin-specific Ab to fluorescently label ribosome-bound puromycylated nascent chains, enabling measurement of translational activity via immunohistochemistry or flow cytometry.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::59946781212fd70cbf6aa4c0bfe1efd9
https://europepmc.org/articles/PMC4976027/
https://europepmc.org/articles/PMC4976027/
Autor:
Raymond M. Welsh, Mina O. Seedhom
Publikováno v:
Current Protocols in Microbiology
Lymphocytic choriomeningitis virus (LCMV) is an enveloped, ambisense RNA virus and the prototypic virus of the arenavirus group. It can cause viral meningitis and other ailments in humans, but its natural host is the mouse. The LCMV/mouse model has b