Zobrazeno 1 - 10
of 195
pro vyhledávání: '"Mina John"'
Autor:
Eric Alves, Marwah Al-Kaabi, Niamh M Keane, Shay Leary, Coral-Ann M Almeida, Pooja Deshpande, Jennifer Currenti, Abha Chopra, Rita Smith, Alison Castley, Simon Mallal, Spyros A Kalams, Silvana Gaudieri, Mina John
Publikováno v:
PLoS Pathogens, Vol 18, Iss 12, p e1010965 (2022)
Adaptation to human leukocyte antigen (HLA)-associated immune pressure represents a major driver of human immunodeficiency virus (HIV) evolution at both the individual and population level. To date, there has been limited exploration of the impact of
Externí odkaz:
https://doaj.org/article/5b3936e98d094b46928ee18e598394bf
Autor:
Jennifer Currenti, Becker M.P. Law, Kai Qin, Mina John, Mark A. Pilkinton, Anju Bansal, Shay Leary, Ramesh Ram, Abha Chopra, Rama Gangula, Ling Yue, Christian Warren, Louise Barnett, Eric Alves, Wyatt J. McDonnell, Anuradha Sooda, Sonya L. Heath, Simon Mallal, Paul Goepfert, Spyros A. Kalams, Silvana Gaudieri
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Loss of T cell immunogenicity due to mutations in virally encoded epitopes is a well-described adaptation strategy to limit host anti-viral immunity. Another described, but less understood, adaptation strategy involves the selection of mutations with
Externí odkaz:
https://doaj.org/article/d451789591d94ef98727693bea82eac9
Autor:
Shay Leary, Silvana Gaudieri, Matthew Parker, Abha Chopra, Ian James, Suman Pakala, Eric Alves, Mina John, Benjamin Lindsey, Alexander Keeley, Sarah Rowland-Jones, Maurice Swanson, David Ostrov, Jodi Bubenik, Suman Das, John Sidney, Alessandro Sette, COVID-19 Genomics UK (COG-UK) consortium, Thushan de Silva, Elizabeth Phillips, Simon Mallal
Publikováno v:
Pathogens and Immunity, Vol 6, Iss 2 (2021)
Background: Genetic variations across the SARS-CoV-2 genome may influence transmissibility of the virus and the host’s anti-viral immune response, in turn affecting the frequency of variants over time. In this study, we examined the adjacent amino
Externí odkaz:
https://doaj.org/article/0e6cb380ed5c485f8c8e44524bb4614b
Autor:
Jennifer Currenti, Abha Chopra, Mina John, Shay Leary, Elizabeth McKinnon, Eric Alves, Mark Pilkinton, Rita Smith, Louise Barnett, Wyatt J McDonnell, Michaela Lucas, Francine Noel, Simon Mallal, Joseph A Conrad, Spyros A Kalams, Silvana Gaudieri
Publikováno v:
PLoS Pathogens, Vol 15, Iss 12, p e1008177 (2019)
Human immunodeficiency virus (HIV) can adapt to an individual's T cell immune response via genomic mutations that affect antigen recognition and impact disease outcome. These viral adaptations are specific to the host's human leucocyte antigen (HLA)
Externí odkaz:
https://doaj.org/article/4d3580a8d0044dc3bfb853a33ffac416
Autor:
Michaela Lucas, Pooja Deshpande, Ian James, Andri Rauch, Katja Pfafferott, Elouise Gaylard, Shahzma Merani, Anne Plauzolles, Andrew Lucas, Wyatt McDonnell, Spyros Kalams, Mark Pilkinton, Cody Chastain, Louise Barnett, Amy Prosser, Simon Mallal, Karen Fitzmaurice, Heidi Drummer, M. Azim Ansari, Vincent Pedergnana, Ellie Barnes, Mina John, Dermot Kelleher, Paul Klenerman, Silvana Gaudieri
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-10 (2018)
Abstract Hepatitis C virus (HCV)-specific T cell responses are critical for immune control of infection. Viral adaptation to these responses, via mutations within regions of the virus targeted by CD8+ T cells, is associated with viral persistence. Ho
Externí odkaz:
https://doaj.org/article/a3e921b0f5654281802b48dc72a509cb
Autor:
Katja Pfafferott, Pooja Deshpande, Elizabeth McKinnon, Shahzma Merani, Andrew Lucas, David Heckerman, Simon Mallal, Mina John, Silvana Gaudieri, Michaela Lucas
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130420 (2015)
Characterisation of Hepatitis C virus (HCV)-specific CD8+ T-cell responses in the context of multiple HCV exposures is critical to identify broadly protective immune responses necessary for an effective HCV vaccine against the different HCV genotypes
Externí odkaz:
https://doaj.org/article/beaef9146df446c3829409a68d4e5832
Autor:
István Bartha, Jonathan M Carlson, Chanson J Brumme, Paul J McLaren, Zabrina L Brumme, Mina John, David W Haas, Javier Martinez-Picado, Judith Dalmau, Cecilio López-Galíndez, Concepción Casado, Andri Rauch, Huldrych F Günthard, Enos Bernasconi, Pietro Vernazza, Thomas Klimkait, Sabine Yerly, Stephen J O’Brien, Jennifer Listgarten, Nico Pfeifer, Christoph Lippert, Nicolo Fusi, Zoltán Kutalik, Todd M Allen, Viktor Müller, P Richard Harrigan, David Heckerman, Amalio Telenti, Jacques Fellay, for the HIV Genome-to-Genome Study and the Swiss HIV Cohort Study
Publikováno v:
eLife, Vol 2 (2013)
HIV-1 sequence diversity is affected by selection pressures arising from host genomic factors. Using paired human and viral data from 1071 individuals, we ran >3000 genome-wide scans, testing for associations between host DNA polymorphisms, HIV-1 seq
Externí odkaz:
https://doaj.org/article/5d773a28930442e492f392ab859e9ef9
Autor:
Katja Pfafferott, Silvana Gaudieri, Axel Ulsenheimer, Ian James, Malte Heeg, David Nolan, Mina John, Andri Rauch, Simon Mallal, Andrew Lucas, Paul Klenerman, Helmut M Diepolder, Michaela Lucas
Publikováno v:
PLoS ONE, Vol 6, Iss 2, p e16797 (2011)
Cellular immune responses during acute Hepatitis C virus (HCV) and HIV infection are a known correlate of infection outcome. Viral adaptation to these responses via mutation(s) within CD8+ T-cell epitopes allows these viruses to subvert host immune c
Externí odkaz:
https://doaj.org/article/82b1436b317041e584a3a3cefc152a36
Autor:
Zabrina L Brumme, Mina John, Jonathan M Carlson, Chanson J Brumme, Dennison Chan, Mark A Brockman, Luke C Swenson, Iris Tao, Sharon Szeto, Pamela Rosato, Jennifer Sela, Carl M Kadie, Nicole Frahm, Christian Brander, David W Haas, Sharon A Riddler, Richard Haubrich, Bruce D Walker, P Richard Harrigan, David Heckerman, Simon Mallal
Publikováno v:
PLoS ONE, Vol 4, Iss 8, p e6687 (2009)
BACKGROUND:Despite the extensive genetic diversity of HIV-1, viral evolution in response to immune selective pressures follows broadly predictable mutational patterns. Sites and pathways of Human Leukocyte-Antigen (HLA)-associated polymorphisms in HI
Externí odkaz:
https://doaj.org/article/960bd37bb9444be3b9de7f493782ec31
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