Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Mina Henes"'
Autor:
Ean Spielvogel, Sook-Kyung Lee, Shuntai Zhou, Gordon J Lockbaum, Mina Henes, Amy Sondgeroth, Klajdi Kosovrasti, Ellen A Nalivaika, Akbar Ali, Nese Kurt Yilmaz, Celia A Schiffer, Ronald Swanstrom
Publikováno v:
eLife, Vol 12 (2023)
Darunavir (DRV) is exceptional among potent HIV-1 protease inhibitors (PIs) in high drug concentrations that are achieved in vivo. Little is known about the de novo resistance pathway for DRV. We selected for resistance to high drug concentrations ag
Externí odkaz:
https://doaj.org/article/63dc44fcc5244ba9ab0bca60d287bf74
Autor:
Ashley N. Matthew, Jacqueto Zephyr, Desaboini Nageswara Rao, Mina Henes, Wasih Kamran, Klajdi Kosovrasti, Adam K. Hedger, Gordon J. Lockbaum, Jennifer Timm, Akbar Ali, Nese Kurt Yilmaz, Celia A. Schiffer
Publikováno v:
mBio, Vol 11, Iss 2 (2020)
ABSTRACT Hepatitis C virus (HCV) infects millions of people worldwide, causing chronic liver disease that can lead to cirrhosis, hepatocellular carcinoma, and liver transplant. In the last several years, the advent of direct-acting antivirals, includ
Externí odkaz:
https://doaj.org/article/c55fb866934b41dabb2b47c634a8609a
Autor:
Gordon J. Lockbaum, Linah N. Rusere, Mina Henes, Klajdi Kosovrasti, Desaboini Nageswara Rao, Ean Spielvogel, Sook-Kyung Lee, Ellen A. Nalivaika, Ronald Swanstrom, Nese Kurt Yilmaz, Celia A. Schiffer, Akbar Ali
Publikováno v:
European Journal of Medicinal Chemistry. 257:115501
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc22305456191ac01cd91889fe25e7b1
https://doi.org/10.1016/j.ejmech.2023.115501
https://doi.org/10.1016/j.ejmech.2023.115501
Autor:
Ean Spielvogel, Sook-Kyung Lee, Shuntai Zhou, Gordon J Lockbaum, Mina Henes, Amy Sondgeroth, Klajdi Kosovrasti, Ellen A Nalivaika, Akbar Ali, Nese Kurt Yilmaz, Celia A Schiffer, Ronald Swanstrom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d2f9584e5a43e5c4421a1c91f47d580
https://doi.org/10.7554/elife.80328.sa2
https://doi.org/10.7554/elife.80328.sa2
Autor:
Nese Kurt Yilmaz, Desaboini Nageswara Rao, Hasahn L. Conway, Mohsan Saeed, Alicia Newton, Adam K. Hedger, Jacqueto Zephyr, Ashley N. Matthew, Akbar Ali, Mina Henes, Elise T Chan, Wei Huang, Christos J. Petropoulos, Celia A. Schiffer
Publikováno v:
J Med Chem
The three pan-genotypic HCV NS3/4A protease inhibitors (PIs) currently in clinical use-grazoprevir, glecaprevir, and voxilaprevir-are quinoxaline-based P2-P4 macrocycles and thus exhibit similar resistance profiles. Using our quinoxaline-based P1-P3
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5522535181ab0aabd2f1c0ce6ac851ee
https://doi.org/10.1021/acs.jmedchem.1c00554
https://doi.org/10.1021/acs.jmedchem.1c00554
Autor:
Florian Leidner, Ashley N. Matthew, Linah N. Rusere, Gordon J. Lockbaum, Mina Henes, Debra A. Ragland, Desaboini Nageswara Rao, Jacqueto Zephyr, Djade I. Soumana, Celia A. Schiffer, Janet L. Paulsen, Nese Kurt Yilmaz, Kristina L. Prachanronarong, Ellen A. Nalivaika, Shurong Hou, Jennifer Timm, Akbar Ali
Publikováno v:
Chem Rev
Drug resistance is prevalent across many diseases, rendering therapies ineffective with severe financial and health consequences. Rather than accepting resistance after the fact, proactive strategies need to be incorporated into the drug design and d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13a52faa3b6205d783bd755f6513d82d
https://doi.org/10.1021/acs.chemrev.0c00648
https://doi.org/10.1021/acs.chemrev.0c00648
Autor:
Gordon J. Lockbaum, Ellen A. Nalivaika, Jennifer Timm, Jeong Min Lee, Celia A. Schiffer, Paul R. Thompson, Nese Kurt Yilmaz, Mina Henes
Publikováno v:
Biochemistry
Rupintrivir targets the 3C cysteine proteases of the picornaviridae family, which includes rhinoviruses and enteroviruses that cause a range of human diseases. Despite being a pan-3C protease inhibitor, rupintrivir activity is extremely weak against
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1866bddf5f1891837ce14fa76717a98c
https://pubmed.ncbi.nlm.nih.gov/34506130
https://pubmed.ncbi.nlm.nih.gov/34506130
Autor:
Gordon J. Lockbaum, Celia A. Schiffer, Ellen A. Nalivaika, Nese Kurt Yilmaz, Linah N. Rusere, Mina Henes, Sook-Kyung Lee, Klajdi Kosovrasti, Ronald Swanstrom, Akbar Ali, Ean Spielvogel
Publikováno v:
J Med Chem
A structure-guided design strategy was used to improve the resistance profile of HIV-1 protease inhibitors by optimizing hydrogen bonding and van der Waals interactions with the protease while staying within the substrate envelope. Stereoisomers of 4
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28fd17d85004f72f6d3054a61ca9e475
https://doi.org/10.1021/acs.jmedchem.9b00838
https://doi.org/10.1021/acs.jmedchem.9b00838
Autor:
Mina Henes, Celia A. Schiffer, Nese Kurt Yilmaz, Mohan Somasundaran, Gordon J. Lockbaum, Linah N. Rusere, Akbar Ali, Ellen A. Nalivaika, Klajdi Kosovrasti, Louis M. Mansky, Nathaniel Talledge
Publikováno v:
ACS Chem Biol
Human T-cell lymphotropic virus type 1 (HTLV-1) is a retrovirus that can cause severe paralytic neurologic disease and immune disorders as well as cancer. An estimated 20 million people worldwide are infected with HTLV-1, with prevalence reaching 30%
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1ef76a256b99966f051bbbb9aa17023
https://pubmed.ncbi.nlm.nih.gov/33619959
https://pubmed.ncbi.nlm.nih.gov/33619959
Autor:
Sook-Kyung Lee, Mina Henes, Ronald Swanstrom, Celia A. Schiffer, Linah N. Rusere, Klajdi Kosovrasti, Ean Spielvogel, Akbar Ali, Gordon J. Lockbaum, Desaboini Nageswara Rao, Nese Kurt Yilmaz, Ellen A. Nalivaika
Publikováno v:
J Med Chem
The design, synthesis, and X-ray structural analysis of hybrid HIV-1 protease inhibitors (PIs) containing bis-tetrahydrofuran (bis-THF) in a pseudo-C2-symmetric dipeptide isostere are described. A series of PIs were synthesized by incorporating bis-T
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::75d68a1620aaedab54d48716ccf0a5ee
https://pubmed.ncbi.nlm.nih.gov/32672965
https://pubmed.ncbi.nlm.nih.gov/32672965