Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Mina, Mirzaian"'
Autor:
Sandra den Hoedt, Simone M. Crivelli, Frank P. J. Leijten, Mario Losen, Jo A. A. Stevens, Marina Mané-Damas, Helga E. de Vries, Jochen Walter, Mina Mirzaian, Eric J. G. Sijbrands, Johannes M. F. G. Aerts, Adrie J. M. Verhoeven, Pilar Martinez-Martinez, Monique T. Mulder
Publikováno v:
Frontiers in Aging Neuroscience, Vol 13 (2021)
Apolipoprotein ε4 (APOE)4 is a strong risk factor for the development of Alzheimer’s disease (AD) and aberrant sphingolipid levels have been implicated in AD. We tested the hypothesis that the APOE4 genotype affects brain sphingolipid levels in AD
Externí odkaz:
https://doaj.org/article/68e0cfda2800491db3a97214c67174e0
Autor:
Lindsey T. Lelieveld, Mina Mirzaian, Chi-Lin Kuo, Marta Artola, Maria J. Ferraz, Remco E.A. Peter, Hisako Akiyama, Peter Greimel, Richard J.B.H.N. van den Berg, Herman S. Overkleeft, Rolf G. Boot, Annemarie H. Meijer, Johannes M.F.G. Aerts
Publikováno v:
Journal of Lipid Research, Vol 60, Iss 11, Pp 1851-1867 (2019)
μ-glucosidases [GBA1 (glucocerebrosidase) and GBA2] are ubiquitous essential enzymes. Lysosomal GBA1 and cytosol-facing GBA2 degrade glucosylceramide (GlcCer); GBA1 deficiency causes Gaucher disease, a lysosomal storage disorder characterized by lys
Externí odkaz:
https://doaj.org/article/05ce0c35bb594489bd17fa37e18c9942
Autor:
Daphne E. Boer, Mina Mirzaian, Maria J. Ferraz, Kimberley C. Zwiers, Merel V. Baks, Marc D. Hazeu, Roelof Ottenhoff, André R.A. Marques, Rianne Meijer, Jonathan C.P. Roos, Timothy M. Cox, Rolf G. Boot, Navraj Pannu, Herman S. Overkleeft, Marta Artola, Johannes M. Aerts
Publikováno v:
Journal of Lipid Research, Vol 62, Iss , Pp 100018- (2021)
Abstract: Deficiency of glucocerebrosidase (GBA), a lysosomal β-glucosidase, causes Gaucher disease. The enzyme hydrolyzes β-glucosidic substrates and transglucosylates cholesterol to cholesterol-β-glucoside. Here we show that recombinant human GB
Externí odkaz:
https://doaj.org/article/bde0e1b5189144b6972b5caa64f21aff
Autor:
Sofie K M, van Zundert, Pieter H, Griffioen, Lenie, van Rossem, Sten P, Willemsen, Yolanda B, de Rijke, Ron H N, van Schaik, Régine P M, Steegers-Theunissen, Mina, Mirzaian
Publikováno v:
Clinical Chemistry and Laboratory Medicine, 61(3), 442-451. De Gruyter
Objectives In this study we describe the development and validation of a liquid chromatography mass spectrometry method (LC-MS/MS) to quantify five tryptophan (TRP) metabolites within the kynurenine– and serotonin pathway and apply the method to se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::736c15c21e5b42a4ee902d4d36c69c47
https://doi.org/10.1515/cclm-2022-0790
https://doi.org/10.1515/cclm-2022-0790
Autor:
AndréR.A. Marques, Mina Mirzaian, Hisako Akiyama, Patrick Wisse, Maria J. Ferraz, Paulo Gaspar, Karen Ghauharali-van der Vlugt, Rianne Meijer, Pilar Giraldo, Pilar Alfonso, Pilar Irún, Maria Dahl, Stefan Karlsson, Elena V. Pavlova, Timothy M. Cox, Saskia Scheij, Marri Verhoek, Roelof Ottenhoff, CindyP.A.A. van Roomen, Navraj S. Pannu, Marco van Eijk, Nick Dekker, Rolf G. Boot, Herman S. Overkleeft, Edward Blommaart, Yoshio Hirabayashi, Johannes M. Aerts
Publikováno v:
Journal of Lipid Research, Vol 57, Iss 3, Pp 451-463 (2016)
The membrane lipid glucosylceramide (GlcCer) is continuously formed and degraded. Cells express two GlcCer-degrading β-glucosidases, glucocerebrosidase (GBA) and GBA2, located in and outside the lysosome, respectively. Here we demonstrate that throu
Externí odkaz:
https://doaj.org/article/57f08df9b338494281ce0b82ea7d752a
Publikováno v:
Journal of Lipid Research, Vol 56, Iss 4, Pp 936-943 (2015)
Sulfatides are found in brain as components of myelin, oligodendrocytes, and neurons but are also present in various visceral tissues. Metachromatic leukodystrophy (MLD) is an inherited lysosomal storage disorder caused by a deficiency of arylsulfata
Externí odkaz:
https://doaj.org/article/751a308332884913a7408d98c42d80e2
Autor:
Sofie van Zundert, Simone van der Padt, Sten Willemsen, Melek Rousian, Mina Mirzaian, Ron van Schaik, Régine Steegers-Theunissen, Lenie van Rossem
Publikováno v:
Nutrients, 14(24):5309. Multidisciplinary Digital Publishing Institute (MDPI)
Nutrients; Volume 14; Issue 24; Pages: 5309
Nutrients; Volume 14; Issue 24; Pages: 5309
Plant-based diets continue to rise in popularity, including among women of reproductive age, while consequences for pregnancy outcomes have hardly been studied. During pregnancy, maternal diet is the only source of proteins for the developing fetus.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2090dbe2cbfe0b71195d1c607a7bd291
https://pure.eur.nl/en/publications/0e5fc749-d514-4868-ad2e-6fbb3676a27f
https://pure.eur.nl/en/publications/0e5fc749-d514-4868-ad2e-6fbb3676a27f
Autor:
Kassiani Kytidou, Thomas J. M. Beenakker, Lotte B. Westerhof, Cornelis H. Hokke, Geri F. Moolenaar, Nora Goosen, Mina Mirzaian, Maria J. Ferraz, Mark de Geus, Wouter W. Kallemeijn, Herman S. Overkleeft, Rolf G. Boot, Arjen Schots, Dirk Bosch, Johannes M. F. G. Aerts
Publikováno v:
Frontiers in Plant Science, Vol 8 (2017)
Deficiency of α-galactosidase A (α-GAL) causes Fabry disease (FD), an X-linked storage disease of the glycosphingolipid globtriaosylcerammide (Gb3) in lysosomes of various cells and elevated plasma globotriaosylsphingosine (Lyso-Gb3) toxic for podo
Externí odkaz:
https://doaj.org/article/65d83c0c2ed34ed3bbeb8805c99ee953
Autor:
Sofie KM van Zundert, Michelle Broekhuizen, Ashley JP Smit, Lenie van Rossem, Mina Mirzaian, Sten P Willemsen, AH Jan Danser, Yolanda B De Rijke, Irwin KM Reiss, Daphne Merkus, Régine PM Steegers-Theunissen
Publikováno v:
International journal of tryptophan research : IJTR. 15
Introduction: Tryptophan is the precursor of kynurenine pathway (KP) metabolites which regulate immune tolerance, energy metabolism, and vascular tone. Since these processes are important during pregnancy, changes in KP metabolite concentrations may
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ebadc901f49ec3eb47a745fca134468
https://pubmed.ncbi.nlm.nih.gov/36467775
https://pubmed.ncbi.nlm.nih.gov/36467775
Autor:
Tanit L Gabriel, Mina Mirzaian, Berend Hooibrink, Roelof Ottenhoff, Cindy van Roomen, Johannes M F G Aerts, Marco van Eijk
Publikováno v:
PLoS ONE, Vol 12, Iss 7, p e0182075 (2017)
During obesity, adipose tissue macrophages (ATM) are increased in concert with local inflammation and insulin resistance. Since the levels of sphingolipid (SLs) in adipose tissue (AT) are altered during obesity we investigated the potential impact of
Externí odkaz:
https://doaj.org/article/b9f9d19f5ca1454db0869eee354abebd