Zobrazeno 1 - 10
of 347
pro vyhledávání: '"Min-xin Guan"'
Autor:
Ningyuan You, Chang Liu, Yuxin Gu, Rong Wang, Hanying Jia, Tianyun Zhang, Song Jiang, Jinsong Shi, Ming Chen, Min-Xin Guan, Siqi Sun, Shanshan Pei, Zhihong Liu, Ning Shen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract We present SpliceTransformer (SpTransformer), a deep-learning framework that predicts tissue-specific RNA splicing alterations linked to human diseases based on genomic sequence. SpTransformer outperforms all previous methods on splicing pre
Externí odkaz:
https://doaj.org/article/94d9c9e7fee1441fbb93d3011b9920e8
Autor:
Lihao Jin, Dingyi Gan, Wentao He, Na Wu, Shuchenlu Xiang, Yinsheng Wei, Gilbert Eriani, Yanchun Ji, Min‐Xin Guan, Meng Wang
Publikováno v:
Advanced Science, Vol 11, Iss 41, Pp n/a-n/a (2024)
Abstract Leber's hereditary optic neuropathy (LHON), a maternally inherited ocular disease, is predominantly caused by mitochondrial DNA (mtDNA) mutations. Mitochondrial tRNA variants are hypothesized to amplify the pathogenic impact of three primary
Externí odkaz:
https://doaj.org/article/09acd8d11e7d4ff6a273c8b8f179e03b
Induced pluripotent stem cells: ex vivo models for human diseases due to mitochondrial DNA mutations
Autor:
Chao Chen, Min-Xin Guan
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-15 (2023)
Abstract Mitochondria are essential organelles for cellular metabolism and physiology in eukaryotic cells. Human mitochondria have their own genome (mtDNA), which is maternally inherited with 37 genes, encoding 13 polypeptides for oxidative phosphory
Externí odkaz:
https://doaj.org/article/a0a3e179970d4d8d9c1085976cd29370
Autor:
Jing Wang, Yanchun Ji, Cheng Ai, Jia-Rong Chen, Dingyi Gan, Juanjuan Zhang, Jun Q. Mo, Min-Xin Guan
Publikováno v:
Journal of Biomedical Science, Vol 30, Iss 1, Pp 1-17 (2023)
Abstract Background Leber’s hereditary optic neuropathy (LHON) is a maternally inherited eye disease due to mutations in mitochondrial DNA. However, there is no effective treatment for this disease. LHON-linked ND6 14484T > C (p.M64V) mutation caus
Externí odkaz:
https://doaj.org/article/88f101b335bf4e43ae57e28557b88262
Publikováno v:
iScience, Vol 27, Iss 2, Pp 108883- (2024)
Summary: Mitochondria are dynamic organelles in cellular metabolism and physiology. Mitochondrial DNA (mtDNA) mutations are associated with a broad spectrum of clinical abnormalities. However, mechanisms underlying mtDNA mutations regulate intracellu
Externí odkaz:
https://doaj.org/article/eb708d73cd5b48f6af30efdd3a6daa46
Autor:
Liang Chen, Yucong Wang, Jiamei Lin, Zhenxing Song, Qinwei Wang, Wenfang Zhao, Yan Wang, Xiaoyu Xiu, Yuqi Deng, Xiuzhi Li, Qiqi Li, Xiaolin Wang, Jingxin Li, Xu Liu, Kunpeng Liu, Jincong Zhou, Kuan Li, Yuchan Liu, Shanhui Liao, Qin Deng, Chao Xu, Qianwen Sun, Shengzhou Wu, Kaiming Zhang, Min-Xin Guan, Tianhua Zhou, Fei Sun, Xiujun Cai, Chuan Huang, Ge Shan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
This study identifies the evolutionarily conserved Exportin 4 as an essential regulator in the nuclear export of circRNAs. Defective circRNA export results in R-loop formation and DNA damage in cells, as well as testis and neurological defects in mic
Externí odkaz:
https://doaj.org/article/bcca5f3009f14c1daba6d2c1908d957c
Autor:
Shu Yang, Bing-Lin Xie, Xiao-ping Dong, Ling-xiang Wang, Gang-hua Zhu, Tian Wang, Wei-jing Wu, Ruo-sha Lai, Rong Tao, Min-xin Guan, Fang-yi Chen, Dong-hui Tan, Zhong Deng, Hua-ping Xie, Yong Zeng, Zi-an Xiao, Ding-hua Xie
Publikováno v:
Frontiers in Molecular Neuroscience, Vol 16 (2023)
IntroductionThe pathogenic gene CDH23 plays a pivotal role in tip links, which is indispensable for mechanoelectrical transduction in the hair cells. However, the underlying molecular mechanism and signal regulatory networks that influence deafness i
Externí odkaz:
https://doaj.org/article/18ffc48731fe4a23ace54779a32202a2
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 20, Iss , Pp 1829-1840 (2022)
The ADP/ATP carrier (AAC) is crucial for mitochondrial functions by importing ADP and exporting ATP across the inner mitochondrial membrane. However, the mechanism of highly specific ADP recognition and transport by AAC remains largely elusive. In th
Externí odkaz:
https://doaj.org/article/2445a9f3c26f42d58bbda28fa52cf481
Autor:
Chengxian Xu, Lingxiao Tong, Jia Rao, Qing Ye, Yuxia Chen, Yingying Zhang, Jie Xu, Xiaoting Mao, Feilong Meng, Huijun Shen, Zhihong Lu, Xiaohui Cang, Haidong Fu, Shugang Wang, Weiyue Gu, En-Yin Lai, Min-Xin Guan, Pingping Jiang, Jianhua Mao
Publikováno v:
JCI Insight, Vol 7, Iss 11 (2022)
Inherited kidney diseases are the fifth most common cause of end-stage renal disease (ESRD). Mitochondrial dysfunction plays a vital role in the progression of inherited kidney diseases, while mitochondrial-transfer RNA (mt-tRNA) variants and their p
Externí odkaz:
https://doaj.org/article/286b853126764869b70ca5a635131c91
Autor:
Shu Zhao, Jia Shi, Guohua Yu, Dali Li, Meng Wang, Chonggang Yuan, Huihui Zhou, Amirabbas Parizadeh, Zhenlin Li, Min-Xin Guan, Shixin Ye
Publikováno v:
Communications Biology, Vol 3, Iss 1, Pp 1-11 (2020)
Using genetic code expansion, Zhao, Shi et al. generate light-sensitive tyrosine analogues to obtain insights into the activation of the NGF receptor, TrkA. They identify light-sensitive and NGF-insensitive phosphorylation sites, validating the appro
Externí odkaz:
https://doaj.org/article/701e78398bee489f8d0e44ae55b19fcc