Zobrazeno 1 - 10
of 133
pro vyhledávání: '"Min-sheng Zhu"'
Autor:
Guang‐Jie Zhu, Yuhang Huang, Linqing Zhang, Keji Yan, Cui Qiu, Yihan He, Qing Liu, Chengwen Zhu, Matías Morín, Miguel Ángel Moreno‐Pelayo, Min‐Sheng Zhu, Xin Cao, Han Zhou, Xiaoyun Qian, Zhigang Xu, Jie Chen, Xia Gao, Guoqiang Wan
Publikováno v:
EMBO Molecular Medicine, Vol 15, Iss 11, Pp n/a-n/a (2023)
Abstract Cingulin (CGN) is a cytoskeleton‐associated protein localized at the apical junctions of epithelial cells. CGN interacts with major cytoskeletal filaments and regulates RhoA activity. However, physiological roles of CGN in development and
Externí odkaz:
https://doaj.org/article/8e775ad618694efebba7ec761a5f62d4
Autor:
Hiroki Takahashi, Ge Yang, Takeshi Yoneshiro, Yohei Abe, Ryo Ito, Chaoran Yang, Junna Nakazono, Mayumi Okamoto-Katsuyama, Aoi Uchida, Makoto Arai, Hitomi Jin, Hyunmi Choi, Myagmar Tumenjargal, Shiyu Xie, Ji Zhang, Hina Sagae, Yanan Zhao, Rei Yamaguchi, Yu Nomura, Yuichi Shimizu, Kaito Yamada, Satoshi Yasuda, Hiroshi Kimura, Toshiya Tanaka, Youichiro Wada, Tatsuhiko Kodama, Hiroyuki Aburatani, Min-Sheng Zhu, Takeshi Inagaki, Timothy F. Osborne, Takeshi Kawamura, Yasushi Ishihama, Yoshihiro Matsumura, Juro Sakai
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
How β-AR signaling coordinates epigenetic and transcriptional pathways is unknown. Here the authors show that cold-induced β-AR signaling negatively regulates MYPT1-PP1β phosphatase activity to orchestrate both pathways for beige adipogenesis.
Externí odkaz:
https://doaj.org/article/208e13262a3c409a916118bc6968d38e
Autor:
Wei Zhao, Jie Sun, Liang-Yu Yao, Dong Hang, Ye-Qiong Li, Cai-Ping Chen, Yu-Wei Zhou, Xin Chen, Tao Tao, Li-Sha Wei, Yan-Yan Zheng, Xie Ge, Chao-Jun Li, Zhong-Cheng Xin, Yang Pan, Xin-Zhu Wang, Wei-Qi He, Xue-Na Zhang, Bing Yao, Min-Sheng Zhu
Publikováno v:
Communications Biology, Vol 5, Iss 1, Pp 1-13 (2022)
Reduced expression of myosin phosphatase target subunit 1 (MYPT1) is critical for the development of vasculogenic erectile dysfunction and a natural compound, lotusine, is found to increase MYPT1 expression and rescue penile smooth muscle function.
Externí odkaz:
https://doaj.org/article/42530947521a4ff28e376521282ac30a
Autor:
Zhisheng Xu, Tingting Fu, Qiqi Guo, Danxia Zhou, Wanping Sun, Zheng Zhou, Xinyi Chen, Jingzi Zhang, Lin Liu, Liwei Xiao, Yujing Yin, Yuhuan Jia, Erkai Pang, Yuncong Chen, Xin Pan, Lei Fang, Min-sheng Zhu, Wenyong Fei, Bin Lu, Zhenji Gan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-20 (2022)
Mitochondrial function is important for muscle maintenance and function, and mitochondrial proteolysis maintains mitochondrial integrity and function. Here the authors report that that loss of LONP1-dependent mitochondrial proteolysis in muscle cause
Externí odkaz:
https://doaj.org/article/52d2f258f2ea4b4b97b27d6c0336a780
Autor:
Wen Yuan, Cong-Cong Cui, Jing Li, Yan-Hua Xu, Chun-E Fan, Yu-Chen Chen, Hong-Wei Fan, Bing-Xue Hu, Mei-Yun Shi, Zhi-Yuan Sun, Pei Wang, Teng-Xiang Ma, Zhao Zhang, Min-Sheng Zhu, Hua-Qun Chen
Publikováno v:
iScience, Vol 25, Iss 11, Pp 105446- (2022)
Summary: Transmembrane protein 16A (TMEM16A) localizes at plasma membrane and controls chloride influx in various type of cells. We here showed an intracellular localization pattern of TMEM16A molecules. In myoblasts, TMEM16A was primarily localized
Externí odkaz:
https://doaj.org/article/0e8e37a69ab44c14aba798409481ef61
Autor:
Xin Chen, Tian-Tian Qiu, Ye Wang, Li-Yang Xu, Jie Sun, Zhi-Hui Jiang, Wei Zhao, Tao Tao, Yu-Wei Zhou, Li-Sha Wei, Ye-Qiong Li, Yan-Yan Zheng, Guo-Hua Zhou, Hua-Qun Chen, Jian Zhang, Xiao-Bo Feng, Fang-Yu Wang, Ning Li, Xue-Na Zhang, Jun Jiang, Min-Sheng Zhu
Publikováno v:
The Journal of Clinical Investigation, Vol 132, Iss 14 (2022)
Intractable functional constipation (IFC) is the most severe form of constipation, but its etiology has long been unknown. We hypothesized that IFC is caused by refractory infection by a pathogenic bacterium. Here, we isolated from patients with IFC
Externí odkaz:
https://doaj.org/article/f66f0af9a68a42ee836c5f2d73db7a57
Autor:
Hailan Meng, Lizhen Fan, Cun-Jin Zhang, Liwen Zhu, Pinyi Liu, Jian Chen, Xinyu Bao, Zhijun Pu, Min-Sheng Zhu, Yun Xu
Publikováno v:
iScience, Vol 24, Iss 9, Pp 103047- (2021)
Summary: Vascular smooth muscle cells (VSMCs) have been widely recognized as key players in regulating blood-brain barrier (BBB) function, and their roles are unclear in ischemic stroke. Myosin phosphatase target subunit 1 (MYPT1) is essential for VS
Externí odkaz:
https://doaj.org/article/4cc446021b6441a593741f4133716340
Distinct Roles of Smooth Muscle and Non-muscle Myosin Light Chain-Mediated Smooth Muscle Contraction
Autor:
Jie Sun, Yan-Ning Qiao, Tao Tao, Wei Zhao, Li-Sha Wei, Ye-Qiong Li, Wei Wang, Ye Wang, Yu-Wei Zhou, Yan-Yan Zheng, Xin Chen, Hong-Chun Pan, Xue-Na Zhang, Min-Sheng Zhu
Publikováno v:
Frontiers in Physiology, Vol 11 (2020)
Both smooth muscle (SM) and non-muscle (NM) myosin II are expressed in hollow organs such as the bladder and uterus, but their respective roles in contraction and corresponding physiological functions remain to be determined. In this report, we asses
Externí odkaz:
https://doaj.org/article/776c932a074f4c99abfbe72754497743
Autor:
Guang-Jie Zhu, Sihao Gong, Deng-Bin Ma, Tao Tao, Wei-Qi He, Linqing Zhang, Fang Wang, Xiao-Yun Qian, Han Zhou, Chi Fan, Pei Wang, Xin Chen, Wei Zhao, Jie Sun, Huaqun Chen, Ye Wang, Xiang Gao, Jian Zuo, Min-Sheng Zhu, Xia Gao, Guoqiang Wan
Publikováno v:
PLoS Genetics, Vol 16, Iss 9, p e1009040 (2020)
Genetic hearing loss is a common health problem with no effective therapy currently available. DFNA15, caused by mutations of the transcription factor POU4F3, is one of the most common forms of autosomal dominant non-syndromic deafness. In this study
Externí odkaz:
https://doaj.org/article/f0246d9084034f89908c03ec0f0b17f6
Autor:
Tingting Fu, Zhisheng Xu, Lin Liu, Qiqi Guo, Hao Wu, Xijun Liang, Danxia Zhou, Liwei Xiao, Lei Liu, Yong Liu, Min-Sheng Zhu, Quan Chen, Zhenji Gan
Publikováno v:
Cell Reports, Vol 23, Iss 5, Pp 1357-1372 (2018)
Summary: The quality of mitochondria in skeletal muscle is essential for maintaining metabolic homeostasis during adaptive stress responses. However, the precise control mechanism of muscle mitochondrial quality and its physiological impacts remain u
Externí odkaz:
https://doaj.org/article/68c874473c9a4d9cb3cd19d7677f7eea