Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Min-Yu Ko"'
Autor:
Chih-Ying Lee, Guan-Chin Su, Wen-Yen Huang, Min-Yu Ko, Hsin-Yi Yeh, Geen-Dong Chang, Sung-Jan Lin, Peter Chi
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
The maintenance polyamines homeostasis is important for cell growth, and several cancers harbor elevated levels of polyamines that may contribute to sustained proliferative potential. Here the authors demonstrate that polyamines participate in DNA do
Externí odkaz:
https://doaj.org/article/7905654691784a7b98c5c9e821361d5d
106
DNA interstrand cross-link (ICL) is one of the most cytotoxic lesions among many kinds of DNA damages. ICLs block essential cellular processes such as DNA replication and transcription, and thus generate DNA double-strand breaks (DSBs). It h
DNA interstrand cross-link (ICL) is one of the most cytotoxic lesions among many kinds of DNA damages. ICLs block essential cellular processes such as DNA replication and transcription, and thus generate DNA double-strand breaks (DSBs). It h
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/brmt65
Autor:
Wen-Fang Cheng, Shih-Han Huang, Ko-Yu Chang, Po-Han Lin, Yu-Li Chen, Chih-Ying Lee, Peter Chi, Min-Yu Ko, Kai-Hang Lei
Publikováno v:
Cancer Research. 81:365-365
Homologous recombination (HR) is an error-free repair pathway to eliminate DNA double-strand breaks and crucial for maintaining genome stability. Pathogenic mutations in genes involved in HR, such as BRCA1 and BRCA2, lead to homologous recombination
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59312d1984ad00b30327e0a388ec723e
https://doi.org/10.1158/1538-7445.am2021-365
https://doi.org/10.1158/1538-7445.am2021-365
Autor:
Sung-Jan Lin, Geen-Dong Chang, Peter Chi, Chih-Ying Lee, Hsin-Yi Yeh, Wen-Yen Huang, Guan-Chin Su, Min-Yu Ko
Publikováno v:
Nature Communications
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Nature Communications, Vol 10, Iss 1, Pp 1-11 (2019)
Polyamines, often elevated in cancer cells, have been shown to promote cell growth and proliferation. Whether polyamines regulate other cell functions remains unclear. Here, we explore whether and how polyamines affect genome integrity. When DNA doub
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37610d68c7e59b19c3e534a9c9e4d93e
https://doi.org/10.1038/s41467-018-08011-1
https://doi.org/10.1038/s41467-018-08011-1
Publikováno v:
Cancer Research. 78:334-334
Homologous recombination (HR) is an error-free repair pathway to eliminate DNA double-strand breaks and cells with deficiency of HR repair are highly sensitive to poly(ADP-ribose) polymerase (PARP) inhibitors. Thus, targeting HR-defective cells becom
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::206c4d5db71e5a6281ff968f7dbf4f71
https://doi.org/10.1158/1538-7445.am2018-334
https://doi.org/10.1158/1538-7445.am2018-334
Autor:
Geen-Dong Chang, Sung-Jan Lin, Guan-Chin Su, Peter Chi, Min-Yu Ko, Chih-Ying Lee, Wen-Yen Huang
Publikováno v:
Cancer Research. 77:2474-2474
Polyamines are essential organic cations for cell growth, proliferation and tissue remodeling. The rate-limiting step in the biosynthesis of polyamines is catalyzed by ornithine decarboxylase (ODC). The activity of ODC and the level of intracellular
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0b7b22f2db908a7c46176fac2a8c6583
https://doi.org/10.1158/1538-7445.am2017-2474
https://doi.org/10.1158/1538-7445.am2017-2474