Zobrazeno 1 - 10
of 54
pro vyhledávání: '"Min-Wu Chao"'
Autor:
Chao-Di Chang, Min-Wu Chao, Hsueh-Yun Lee, Yi-Ting Liu, Huang-Ju Tu, Ssu-Ting Lien, Tony Eight Lin, Tzu-Ying Sung, Shih-Chung Yen, Sing-Han Huang, Kai-Cheng Hsu, Shiow-Lin Pan
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 38, Iss 1 (2023)
Inhibiting a specific target in cancer cells and reducing unwanted side effects has become a promising strategy in pancreatic cancer treatment. MAP4K4 is associated with pancreatic cancer development and correlates with poor clinical outcomes. By pho
Externí odkaz:
https://doaj.org/article/eeb87040e05f48b3ad27fb6a79897905
Autor:
Tony Eight Lin, Li-Chin Sung, Min-Wu Chao, Min Li, Jia-Huei Zheng, Tzu-Ying Sung, Jui-Hua Hsieh, Chia-Ron Yang, Hsueh-Yun Lee, Er-Chieh Cho, Kai-Cheng Hsu
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 37, Iss 1, Pp 226-235 (2022)
Bruton tyrosine kinase (BTK) is linked to multiple signalling pathways that regulate cellular survival, activation, and proliferation. A covalent BTK inhibitor has shown favourable outcomes for treating B cell malignant leukaemia. However, covalent i
Externí odkaz:
https://doaj.org/article/4eee7f20c593416abeb5853c9de04c92
Autor:
Yi-Wen Wu, Min-Wu Chao, Huang-Ju Tu, Liang-Chieh Chen, Kai-Cheng Hsu, Jing-Ping Liou, Chia-Ron Yang, Shih-Chung Yen, Wei-Chun HuangFu, Shiow-Lin Pan
Publikováno v:
Oncogenesis, Vol 10, Iss 5, Pp 1-14 (2021)
Abstract Acute leukemia is a highly heterogeneous disease; therefore, combination therapy is commonly used for patient treatment. Drug–drug interaction is a major concern of combined therapy; hence, dual/multi-target inhibitors have become a domina
Externí odkaz:
https://doaj.org/article/8dd26522ac6d4593b41471029e8816c9
Autor:
Min-Wu Chao, Tony Eight Lin, Wei-Chun HuangFu, Chao-Di Chang, Huang-Ju Tu, Liang-Chieh Chen, Shih-Chung Yen, Tzu-Ying Sung, Wei-Jan Huang, Chia-Ron Yang, Shiow-Lin Pan, Kai-Cheng Hsu
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 36, Iss 1, Pp 98-108 (2021)
The STE20 kinase family is a complex signalling cascade that regulates cytoskeletal organisation and modulates the stress response. This signalling cascade includes various kinase mediators, such as TAOK1 and MAP4K5. The dysregulation of the STE20 ki
Externí odkaz:
https://doaj.org/article/a23f5c3bf07c4ef483bac5eb846abc10
Autor:
Tony Eight Lin, Chia-Ron Yang, Ching-Hsuan Chou, Jui-Yi Hsu, Min-Wu Chao, Tzu-Ying Sung, Jui-Hua Hsieh, Wei-Jan Huang, Kai-Cheng Hsu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 146, Iss , Pp 112459- (2022)
Chronic inflammation is an underlying cause in a number of diseases. Cyclin-dependent kinase 8 (CDK8) has been implicated as an inflammatory mediator, indicating its potential as an anti-inflammatory target. Herein, we performed structure-based virtu
Externí odkaz:
https://doaj.org/article/0571fe428d584aff829c19f8da7aaa05
Autor:
Tony Eight Lin, Min-Wu Chao, Wei-Chun HuangFu, Huang-Ju Tu, Zhao-Xiang Peng, Chih-Jou Su, Tzu-Ying Sung, Jui-Hua Hsieh, Cheng-Chung Lee, Chia-Ron Yang, Shiow-Lin Pan, Kai-Cheng Hsu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 146, Iss , Pp 112580- (2022)
The dysregulation of DYRK1A is implicated in many diseases such as cancer, diabetes, and neurodegenerative diseases. Alzheimer’s disease is one of the most common neurodegenerative disease and has elevated interest in DYRK1A research. Overexpressio
Externí odkaz:
https://doaj.org/article/bde6aaca1032477f872fda9997782694
Autor:
Min-Wu Chao, Li-Hsun Chang, Huang-Ju Tu, Chao-Di Chang, Mei-Jung Lai, Yi-Ying Chen, Jing-Ping Liou, Che-Ming Teng, Shiow-Lin Pan
Publikováno v:
Clinical Epigenetics, Vol 11, Iss 1, Pp 1-14 (2019)
Abstract Background Oncogenic K-Ras signaling highly relies on the canonical Ras/MEK/ERK pathway to contribute to pancreatic cancer progression. However, numerous efforts of MEK inhibitors have failed to provide an optimal antitumor effect for pancre
Externí odkaz:
https://doaj.org/article/a43186bb4cd346d8948e060ed50b9538
Autor:
Huang-Ju Tu, Yi-Jyun Lin, Min-Wu Chao, Ting-Yi Sung, Yi-Wen Wu, Yi-Ying Chen, Mei-Hsiang Lin, Jing-Ping Liou, Shiow-Lin Pan, Chia-Ron Yang
Publikováno v:
Clinical Epigenetics, Vol 10, Iss 1, Pp 1-13 (2018)
Abstract Background There are some limitations of standard chemotherapy for acute leukemia. Vincristine and doxorubicin are commonly used for acute leukemia, but they may induce serious side effects such as cardiomyopathy and neurotoxicity. Furthermo
Externí odkaz:
https://doaj.org/article/08f7b82eaf5342078ac9c93290b19cec
Autor:
Tony Eight Lin, Wei-Chun HuangFu, Min-Wu Chao, Tzu-Ying Sung, Chao-Di Chang, Yi-Ying Chen, Jui-Hua Hsieh, Huang-Ju Tu, Han-Li Huang, Shiow-Lin Pan, Kai-Cheng Hsu
Publikováno v:
Frontiers in Pharmacology, Vol 9 (2018)
The JAK2/STAT signaling pathway mediates cytokine receptor signals that are involved in cell growth, survival and homeostasis. JAK2 is a member of the Janus kinase (JAK) family and aberrant JAK2/STAT is involved with various diseases, making the path
Externí odkaz:
https://doaj.org/article/53feeaf4e47a4482ada47bbc6e155336
Publikováno v:
PLoS ONE, Vol 7, Iss 9, p e44093 (2012)
α-Tomatine, a tomato glycoalkaloid, has been reported to possess antibiotic properties against human pathogens. However, the mechanism of its action against leukemia remains unclear. In this study, the therapeutic potential of α-tomatine against le
Externí odkaz:
https://doaj.org/article/830d1db1cb00483cba24ac52b6f5e390