Zobrazeno 1 - 4
of 4
pro vyhledávání: '"Min-Ru Jiao"'
Publikováno v:
Pharmaceutical Fronts, Vol 04, Iss 02, Pp e61-e70 (2022)
Abstract Targeting histone deacetylases (HDACs) has become an important focus in cancer inhibition. The pharmacophore of HDAC inhibitors (HDACis) reported so far is composed of three parts: a zinc-binding group (ZBG), a hydrophobic cavity-binding li
Externí odkaz:
https://doaj.org/article/889a1440851841b9ae6ecfa4c4b20c8e
Publikováno v:
Pharmaceutical Fronts, Vol 04, Iss 01, Pp e22-e29 (2022)
Abstract In this study, the synthesis and biological evaluation of a variety of benzoheterocyclic-containing benzamide derivatives were described. Some of these compounds were proved to inhibiting the activity of histone deacetylase 1 (HDAC1) with IC
Externí odkaz:
https://doaj.org/article/652a7f8b7fe445a4a95d61be96e99bb0
Publikováno v:
Pharmaceutical Fronts, Vol 03, Iss 03, Pp e113-e118 (2021)
Abstract This study reported an asymmetric synthesis of 1,2-limonene epoxides. The absolute stereochemistry was controlled by a Jacobsen epoxidation of cis-1,2-limonene epoxide (with diastereomeric excess of 98%) and trans-1,2-limonene epoxide (with
Externí odkaz:
https://doaj.org/article/e077b38b0bb142febb61e3030459d19f
Publikováno v:
Pharmaceutical Fronts, Vol 03, Iss 01, Pp e1-e7 (2021)
Abstract A novel series of quinazoline derivatives were designed, synthesized, and evaluated as multikinase inhibitors. Most of these compounds showed antiproliferation activities of several human cancer cell lines and exhibited inhibition efficacy a
Externí odkaz:
https://doaj.org/article/eaefe007f52e4ce596062c959176ea2e