Zobrazeno 1 - 10
of 46
pro vyhledávání: '"Min-Joon Han"'
Autor:
Majd Khiami, Yan Ju, Lei Han, Jonathan Klein, Min-Joon Han, Shondra M. Pruett-Miller, Marcin W. Wlodarski
Publikováno v:
Stem Cell Research, Vol 81, Iss , Pp 103532- (2024)
Induced pluripotent stem cells (iPSCs) harboring patient derived SAMD9 mutation offer a unique platform to study the multi-organ involvement observed in this rare disease, referred to as myelodysplasia, infections, restriction of growth, adrenal hypo
Externí odkaz:
https://doaj.org/article/0c12dce7c9574b02bd12643e74df49a5
Autor:
Sejeong Shin, Min-Joon Han, Mark P. Jedrychowski, Ziyang Zhang, Kevan M. Shokat, David R. Plas, Noah Dephoure, Sang-Oh Yoon
Publikováno v:
Cell Reports, Vol 42, Iss 8, Pp 112868- (2023)
Summary: Cells maintain and dynamically change their proteomes according to the environment and their needs. Mechanistic target of rapamycin (mTOR) is a key regulator of proteostasis, homeostasis of the proteome. Thus, dysregulation of mTOR leads to
Externí odkaz:
https://doaj.org/article/e32b0783630a4739a55f2de3b20572f4
Autor:
Elizabeth D. Buttermore, Nickesha C. Anderson, Pin-Fang Chen, Nina R. Makhortova, Kristina H. Kim, Syed M. A. Wafa, Sean Dwyer, John M. Micozzi, Kellen D. Winden, Bo Zhang, Min-Joon Han, Robin J. Kleiman, Catherine A. Brownstein, Mustafa Sahin, Joseph Gonzalez-Heydrich
Publikováno v:
Frontiers in Psychiatry, Vol 13 (2022)
16p13.11 copy number variants (CNVs) have been associated with autism, schizophrenia, psychosis, intellectual disability, and epilepsy. The majority of 16p13.11 deletions or duplications occur within three well-defined intervals, and despite growing
Externí odkaz:
https://doaj.org/article/bedda704b0ec4e45b715988a86bb44c5
Autor:
Ida Annunziata, Diantha van de Vlekkert, Elmar Wolf, David Finkelstein, Geoffrey Neale, Eda Machado, Rosario Mosca, Yvan Campos, Heather Tillman, Martine F. Roussel, Jason Andrew Weesner, Leigh Ellen Fremuth, Xiaohui Qiu, Min-Joon Han, Gerard C. Grosveld, Alessandra d’Azzo
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-18 (2019)
Genes related to lysosomal and autophagic systems are transcriptionally regulated by the Mit/TFE family of transcription factors. Here the authors show that MYC, in association with HDACs, suppresses the expression of lysosomal and autophagy genes by
Externí odkaz:
https://doaj.org/article/642d6aea132848be83c0cf12d1e5c471
Autor:
Min-Joon Han, Ida Annunziata, Jason Weesner, Yvan Campos, Muneeb Salie, Carla O'Reilly, Alessandra d'Azzo
Publikováno v:
Stem Cell Research, Vol 46, Iss , Pp 101836- (2020)
Sialidosis is an autosomal recessive lysosomal storage disease, belonging to the glycoproteinoses. The disease is caused by deficiency of the sialic acid-cleaving enzyme, sialidase 1 or neuraminidase 1 (NEU1). Patients with sialidosis are classified
Externí odkaz:
https://doaj.org/article/54b0b88fc04045d5b1ac57709d78fd3a
Publikováno v:
Biochemistry and Biophysics Reports, Vol 20, Iss , Pp - (2019)
Naïve pluripotent stem cells (PSCs) display a distinctive phenotype when compared to their “primed” counterparts, including, but not limited to, increased potency to differentiate and more robust mitochondrial respiration. The cultivation and ma
Externí odkaz:
https://doaj.org/article/c2261593af5b4587aded71d01e4487b6
Autor:
Darius Ebrahimi-Fakhari, Afshin Saffari, Lara Wahlster, Alessia Di Nardo, Daria Turner, Tommy L. Lewis Jr., Christopher Conrad, Jonathan M. Rothberg, Jonathan O. Lipton, Stefan Kölker, Georg F. Hoffmann, Min-Joon Han, Franck Polleux, Mustafa Sahin
Publikováno v:
Cell Reports, Vol 17, Iss 4, Pp 1053-1070 (2016)
Tuberous sclerosis complex (TSC) is a neurodevelopmental disease caused by TSC1 or TSC2 mutations and subsequent activation of the mTORC1 kinase. Upon mTORC1 activation, anabolic metabolism, which requires mitochondria, is induced, yet at the same ti
Externí odkaz:
https://doaj.org/article/5ed8e2bf932447198481e0e69bebd50d
Autor:
Yong Cheng, Sang-Oh Yoon, Junmin Peng, Sharon Frase, Carla O'Reilly, John D. Schuetz, Jennifer L. Peters, Yu Fukuda, Qian Qi, Min-Joon Han, Ji-Hoon Cho
Publikováno v:
Exp Cell Res
Metabolic studies of human pluripotent stem cells (hPSCs) have focused on how the cells produce energy through the catabolic pathway. The less-studied anabolic pathway, by which hPSCs expend energy in the form of adenosine triphosphate (ATP), is not
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6d4c0d4cf2c8a7b78e1a3abb4917d163
https://doi.org/10.1016/j.yexcr.2019.03.028
https://doi.org/10.1016/j.yexcr.2019.03.028
Autor:
Min-Joon Han, Chun-Hyung Kim, Kyuboem Han, Eun-Hye Lee, Jung Il Moon, Chang-Hwan Park, Yu Shin Hye, Sang Mi Kim
Publikováno v:
BMB Reports
Recent progress in cellular reprogramming technology and lineage-specific cell differentiation has provided great opportunities for translational research. Because virus-based gene delivery is not a practical reprogramming protocol, protein-based rep
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9a2b6c8e500d05ea30a82a8c9a76a0c8
http://europepmc.org/articles/PMC6549919
http://europepmc.org/articles/PMC6549919
Autor:
Buttermore, Elizabeth D., Anderson, Nickesha C., Pin-Fang Chen, Makhortova, Nina R., Kim, Kristina H., Wafa, Syed M. A., Dwyer, Sean, Micozzi, John M., Winden, Kellen D., Bo Zhang, Min-Joon Han, Kleiman, Robin J., Brownstein, Catherine A., Sahin, Mustafa, Gonzalez-Heydrich, Joseph
Publikováno v:
Frontiers in Psychiatry; 11/3/2022, Vol. 13, p1-14, 14p