Zobrazeno 1 - 10
of 39
pro vyhledávání: '"Min-Hwa Jasmine Lin"'
Autor:
Bryan D. Moyer, Brad Herberich, Kaustav Biswas, Kenneth W. Walker, Beth D. Youngblood, Jennifer Aral, Tayo Ikotun, Min-Hwa Jasmine Lin, Linh Tran, Thomas Kornecook, Hongyan Li, Thomas Nixey, Joseph Ligutti, Shanti Amagasu, Li Yin, Xuhai Be, Kristin L. Andrews, Christopher M. Tegley, Charles Glaus, Marcus Soto, Les P. Miranda, James R. Falsey, Jason Long, Yuan Cheng, Robert S. Foti, Hossein Salimi-Moosavi, Kelvin Sham, Christopher P Ilch, Bin Wu, Justin K. Murray, Margaret Karow, Chawita Netirojjanakul, Liz Doherty
Publikováno v:
ACS Chemical Biology. 14:806-818
Drug discovery research on new pain targets with human genetic validation, including the voltage-gated sodium channel NaV1.7, is being pursued to address the unmet medical need with respect to chronic pain and the rising opioid epidemic. As part of e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::68d1aa4016111a37796e962e98dcd944
https://doi.org/10.1021/acschembio.9b00183
https://doi.org/10.1021/acschembio.9b00183
Autor:
Bin Wu, Shanti Amagasu, Jason Long, Justin K. Murray, Kristin L. Andrews, Jennifer Aral, Les P. Miranda, Xuhai Be, Kaustav Biswas, Min-Hwa Jasmine Lin, Dong Liu, Zhulun Wang, Anruo Zou, Bryan D. Moyer, Joseph Ligutti, Xiaoshan Min, Kelvin Sham, Thomas Kornecook, Christopher P Ilch
Publikováno v:
Journal of Medicinal Chemistry. 61:9500-9512
Inhibitors of the voltage-gated sodium channel NaV1.7 are being investigated as pain therapeutics due to compelling human genetics. We previously identified NaV1.7-inhibitory peptides GpTx-1 and JzTx-V from tarantula venom screens. Potency and select
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::12d64da5d997f9baadd80104c5f149b5
https://doi.org/10.1021/acs.jmedchem.8b00736
https://doi.org/10.1021/acs.jmedchem.8b00736
Autor:
Stefan I. McDonough, Min-Hwa Jasmine Lin, Erin F. DiMauro, Violeta Yu, Angel Guzman-Perez, Kristin Taborn, Christiane Bode, Thomas Kornecook, Thomas Dineen, Xin Huang, Robert T. Fremeau, Margaret Chu-Moyer, James R. Coats, Bingfan Du, Jeff S. McDermott, Hakan Gunaydin, Daniel S. La, Hua Gao, Bryan D. Moyer, Russell Graceffa, Alessandro Boezio, Charles Kreiman, Matthew Weiss, Hanh Nho Nguyen, David J. Matson, Joseph Ligutti, Christopher P Ilch, Isaac E. Marx, Emily A. Peterson, Howard Bregman
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 27:3477-3485
The voltage-gated sodium channel NaV1.7 has received much attention from the scientific community due to compelling human genetic data linking gain- and loss-of-function mutations to pain phenotypes. Despite this genetic validation of NaV1.7 as a tar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b9bf06b4e0a447e6a5e64c58b6fc67fa
https://doi.org/10.1016/j.bmcl.2017.05.070
https://doi.org/10.1016/j.bmcl.2017.05.070
Autor:
Jessica Able, Benjamin C. Milgram, Loren Berry, Melanie Cooke, Liyue Huang, John Butler, Hongbing Huang, Violeta Yu, Kristin Taborn, John D. Roberts, Steven Altmann, Margaret Y. Chu-Moyer, John Yeoman, Jean Wang, Roman Shimanovich, Russell Graceffa, Matthew Weiss, Thomas Kornecook, Christopher P Ilch, Bryan D. Moyer, Christiane Boezio, Isaac E. Marx, Brian A. Sparling, Emily A. Peterson, Gwen Rescourio, Charles Kreiman, Elma Feric Bojic, Karina R. Vaida, Angel Guzman-Perez, Dawn Zhu, Hua Gao, Laurie B. Schenkel, Michael Jarosh, Hanh Nho Nguyen, Joseph Ligutti, Alessandro Boezio, Hakan Gunaydin, Daniel S. La, Thomas Dineen, Robert T. Fremeau, Robert S. Foti, Min-Hwa Jasmine Lin, Erin F. DiMauro, John Stellwagen
Publikováno v:
Journal of Medicinal Chemistry. 60:5990-6017
Because of its strong genetic validation, NaV1.7 has attracted significant interest as a target for the treatment of pain. We have previously reported on a number of structurally distinct bicyclic heteroarylsulfonamides as NaV1.7 inhibitors that demo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::bb6062704d531ce83c1a6122ecc44600
https://doi.org/10.1021/acs.jmedchem.6b01850
https://doi.org/10.1021/acs.jmedchem.6b01850
Autor:
Robert T. Fremeau, Isaac E. Marx, Emily A. Peterson, Charles Kreiman, Thomas Dineen, Hua Gao, Alessandro Boezio, Hakan Gunaydin, Min-Hwa Jasmine Lin, Steven Altmann, Elma Feric Bojic, Kristin Taborn, Robert S. Foti, Russell Graceffa, Daniel S. La, Liyue Huang, Matthew Weiss, Paul E. Rose, Angel Guzman-Perez, Beth D. Youngblood, Hongbing Huang, Violeta Yu, Dong Liu, Thomas Kornecook, Bryan D. Moyer, Howard Bregman, Hanh Nho Nguyen, Joseph Ligutti, Margaret Y. Chu-Moyer, Michael Jarosh, Erin F. DiMauro
Publikováno v:
Journal of Medicinal Chemistry. 60:5969-5989
Several reports have recently emerged regarding the identification of heteroarylsulfonamides as NaV1.7 inhibitors that demonstrate high levels of selectivity over other NaV isoforms. The optimization of a series of internal NaV1.7 leads that address
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3616b7030b42538cb45a4828f9c4821e
https://doi.org/10.1021/acs.jmedchem.6b01851
https://doi.org/10.1021/acs.jmedchem.6b01851
Autor:
Justin K, Murray, Bin, Wu, Christopher M, Tegley, Thomas E, Nixey, James R, Falsey, Brad, Herberich, Li, Yin, Kelvin, Sham, Jason, Long, Jennifer, Aral, Yuan, Cheng, Chawita, Netirojjanakul, Liz, Doherty, Charles, Glaus, Tayo, Ikotun, Hongyan, Li, Linh, Tran, Marcus, Soto, Hossein, Salimi-Moosavi, Joseph, Ligutti, Shanti, Amagasu, Kristin L, Andrews, Xuhai, Be, Min-Hwa Jasmine, Lin, Robert S, Foti, Christopher P, Ilch, Beth, Youngblood, Thomas J, Kornecook, Margaret, Karow, Kenneth W, Walker, Bryan D, Moyer, Kaustav, Biswas, Les P, Miranda
Publikováno v:
ACS chemical biology. 14(4)
Drug discovery research on new pain targets with human genetic validation, including the voltage-gated sodium channel Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::a795b15b8b6e13088e7422d887dacec6
https://pubmed.ncbi.nlm.nih.gov/30875193
https://pubmed.ncbi.nlm.nih.gov/30875193
Autor:
Karen Rex, Douglas A. Whittington, David Bauer, Steven F. Bellon, Jean-Christophe Harmange, Martin A. Broome, Alessandro Boezio, Christiane Boezio, Karina R. Vaida, Deborah Choquette, Isabelle Dussault, Katrina W. Copeland, Emily A. Peterson, Yohannes Teffera, Roman Shimanovich, Brian K. Albrecht, Richard T. Lewis, Michele Potashman, Jingzhou Liu, Julia Lohman, Angela Coxon, Min-Hwa Jasmine Lin, Satoko Hirai
Publikováno v:
Journal of Medicinal Chemistry. 59:2328-2342
Deregulation of the receptor tyrosine kinase mesenchymal epithelial transition factor (MET) has been implicated in several human cancers and is an attractive target for small molecule drug discovery. Herein, we report the discovery of compound 23 (AM
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d16401f5e9358f2456fce2725cd044c7
https://doi.org/10.1021/acs.jmedchem.5b01716
https://doi.org/10.1021/acs.jmedchem.5b01716
Autor:
Holly L. Deak, Richard Kendall, Chaves Mary, Robert Radinsky, Grace Chung, Annette Bak, Yang Dai, Bingfan Du, Karina R. Vaida, Min-Hwa Jasmine Lin, Hanh Nho Nguyen, Brian L. Hodous, Laurie B. Schenkel, Tammy L. Bush, Patrick Eden, Paul S. Andrews, Liyue Huang, Xuhai Be, Philip R. Olivieri, Stephanie D. Geuns-Meyer, Victor J. Cee, Kelly Hanestad, Marc Payton, Jin Tang, Vinod F. Patel, Pedro J. Beltran, Beth Ziegler
Publikováno v:
Journal of Medicinal Chemistry. 58:5189-5207
Efforts to improve upon the physical properties and metabolic stability of Aurora kinase inhibitor 14a revealed that potency against multidrug-resistant cell lines was compromised by increased polarity. Despite its high in vitro metabolic intrinsic c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::12730d02cfac93673e41d912f0563da7
https://doi.org/10.1021/acs.jmedchem.5b00183
https://doi.org/10.1021/acs.jmedchem.5b00183
Autor:
Kaustav, Biswas, Thomas E, Nixey, Justin K, Murray, James R, Falsey, Li, Yin, Hantao, Liu, Jacinthe, Gingras, Brian E, Hall, Brad, Herberich, Jerry Ryan, Holder, Hongyan, Li, Joseph, Ligutti, Min-Hwa Jasmine, Lin, Dong, Liu, Brian D, Soriano, Marcus, Soto, Linh, Tran, Christopher M, Tegley, Anrou, Zou, Kannan, Gunasekaran, Bryan D, Moyer, Liz, Doherty, Les P, Miranda
Publikováno v:
ACS chemical biology. 12(9)
The voltage-gated sodium channel Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::9d9d63324300be54bf17aab5fbfa3c14
https://pubmed.ncbi.nlm.nih.gov/28800217
https://pubmed.ncbi.nlm.nih.gov/28800217
Autor:
Daniel S, La, Emily A, Peterson, Christiane, Bode, Alessandro A, Boezio, Howard, Bregman, Margaret Y, Chu-Moyer, James, Coats, Erin F, DiMauro, Thomas A, Dineen, Bingfan, Du, Hua, Gao, Russell, Graceffa, Hakan, Gunaydin, Angel, Guzman-Perez, Robert, Fremeau, Xin, Huang, Christopher, Ilch, Thomas J, Kornecook, Charles, Kreiman, Joseph, Ligutti, Min-Hwa, Jasmine Lin, Jeff S, McDermott, Isaac, Marx, David J, Matson, Stefan I, McDonough, Bryan D, Moyer, Hanh, Nho Nguyen, Kristin, Taborn, Violeta, Yu, Matthew M, Weiss
Publikováno v:
Bioorganicmedicinal chemistry letters. 27(15)
The voltage-gated sodium channel Na
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::02795d6ccd5623aa35b5da1b11eb85e5
https://pubmed.ncbi.nlm.nih.gov/28629594
https://pubmed.ncbi.nlm.nih.gov/28629594