High water intake induces primary cilium elongation in renal tubular cells

Autor: Min Jung Kong, Sang Jun Han, Sung Young Seu, Ki-Hwan Han, Joshua H. Lipschutz, Kwon Moo Park

Publikováno v: Kidney Research and Clinical Practice, Vol 43, Iss 3, Pp 313-325 (2024)

Background The primary cilium protrudes from the cell surface and functions as a mechanosensor. Recently, we found that water intake restriction shortens the primary cilia of renal tubular cells, and a blockage of the shortening disturbs the ability

Externí odkaz: https://doaj.org/article/ae637f382c874171ba9a177b288547da

Macrophages promote Fibrinogenesis during kidney injury

Autor: Hanna Oh, Ohbin Kwon, Min Jung Kong, Kwon Moo Park, Jea-Hyun Baek

Publikováno v: Frontiers in Medicine, Vol 10 (2023)

Macrophages (Mø) are widely considered fundamental in the development of kidney fibrosis since Mø accumulation commonly aggravates kidney fibrosis, while Mø depletion mitigates it. Although many studies have aimed to elucidate Mø-dependent mechan

Externí odkaz: https://doaj.org/article/2ff72db753c04a73849332f1db2970aa

Fragmentation of kidney epithelial cell primary cilia occurs by cisplatin and these cilia fragments are excreted into the urine

Autor: Min Jung Kong, Sang Hong Bak, Ki-Hwan Han, Jee In Kim, Jeen-Woo Park, Kwon Moo Park

Publikováno v: Redox Biology, Vol 20, Iss , Pp 38-45 (2019)

The primary cilium, which protrudes from the cell surface, is associated with the pathogenesis of various diseases, including acute kidney injury (AKI). Primary cilium length dynamically changes during the progression of diseases. However, its releva

Externí odkaz: https://doaj.org/article/ac1da18042c24230af03f0d92b7452ba

Rac1 inhibition protects the kidney against kidney ischemia/reperfusion through the inhibition of macrophage migration.

Autor: You Ri Park¹, Min Jung Kong², Mi Ra Noh¹, Kwon Moo Park^1,2,3 kmpark@knu.ac.kr

Publikováno v: Korean Journal of Physiology & Pharmacology. May2023, Vol. 27 Issue 3, p257-265. 9p.

A nonbiodegradable scaffold-free cell sheet of genome-engineered mesenchymal stem cells inhibits development of acute kidney injury

Autor: Jørgen Frøkiær, Inkyu Lee, Jeong-In Cho, Min Jung Kong, Hye-Jeong Park, Rikke Nørregaard, Eui-Jung Park, Tae-Hwan Kwon, Hyo-Ju Jang, Kwon Moo Park

Publikováno v: Park, H J, Kong, M J, Jang, H J, Cho, J I, Park, E J, Lee, I K, Frøkiær, J, Norregaard, R, Park, K M & Kwon, T H 2021, ' A nonbiodegradable scaffold-free cell sheet of genome-engineered mesenchymal stem cells inhibits development of acute kidney injury ', Kidney International, vol. 99, no. 1, pp. 117-133 . https://doi.org/10.1016/j.kint.2020.07.043

Cell therapy using genome-engineered stem cells has emerged as a novel strategy for the treatment of kidney diseases. By exploiting genome editing technology, human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) secreting an angiogenic fact

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5af5af40809ac85fd814e598200b5c57
https://doi.org/10.1016/j.kint.2020.07.043